CLINICAL PROFILE, PRESCRIPTION PATTERNS, AND ADVERSE DRUG REACTIONS IN PATIENTS WITH VITILIGO: A PROSPECTIVE STUDY

Objectives: The objectives of the study were to assess clinical profile (age of onset, age of presentation, gender, site of involvement, severity (stage), type of vitiligo, triggering factors, and associated diseases), prescription patterns (monotherapy, combination therapy, oral, topical, and therapeutic categories of drugs prescribed) and to monitor and report adverse drug reactions (based on World Health Organization [WHO] causality assessment scale) in vitiligo patients. Methods: A hospital-based prospective observational study was carried out by evaluating and assessing the clinical profile and prescription patterns of 85 patients who attended dermatology venereology and leprosy (DVL) outpatient department at Sri Padmavathi Medical College for Women, SVIMS, Tirupati, over a period of 6 months from June 2019 to December 2019. Results: In our study, forty four (51.77%) patients were female, vitiligo vulgaris is the most common morphological type observed in twenty seven (31.76%) patients. 31–50 years was the predominant age group. The mean age of onset and presentation was 38.35 (standard deviation of 18.37) and 43.27 (standard deviation of 17.96) years, respectively. Forty-one (48.23%) patients were having Stage 1 vitiligo. Fifty (58.85%) patients were having vitiligo at more than 1 site. Twelve (14.11%) patients were having a positive family history of vitiligo. Thirty-seven (43.53%) patients had triggering factors. Associated diseases were found in thirty (35%) patients. Combination therapy was given to sixty one (71.77%) patients. Topical medications were given to fifty two (61.18%) patients. During the study, we did not have a single patient complaining of any adverse drug reaction. Conclusion: Longer the time after appearance of vitiligo, lesser the number of patients attending follow-up. If vitiligo is diagnosed at the earliest stage, more are the chances for complete repigmentation. Patients with a poor economic background are less bothered about their skin condition and are not using medications properly

Modeling and Analysis of Time Response Parameters of a PMSM-Based Electric Vehicle with PI and PID Controllers

This paper presents the mathematical modeling of a vector-controlled Permanent Magnet Synchronous Motor (PMSM) drive with either a Proportional Integral (PI) controller or a Proportional Integral Derivative (PID) controller as a propulsion system for an Electric Vehicle (EV). Most commercial drives use a standard PI controller as a speed regulator. The vector control system model consists of the PMSM, a PWM inverter, the speed controller, and vehicle dynamics for speed control. The performance analysis of the drive is evaluated under transient conditions for settling time, rise time, steady state error of speed, and the vehicle’s acceleration at the wheel axle for specifically designated values validated by MATLAB/Simulink

Production of pullulan using jaggery as substrate by Aureobasidium pullulans MTCC 2195

Shake-flask fermentation, under batch cultivation, was investigated for the production of fungal exopolysaccharide, pullulan using jaggery (a traditional concentrated sugar cane juice) as a carbon substrate by Aureobasidium pullulans MTCC 2195. Change in the initial pH (from 3.0 to 7.0) of media containing jaggery was varied to study the effect of pH in the fermentation and maximum pullulan yield was obtained at a pH of 5.0. An increase in the initial concentrations (50, 75, 100 g/L) of jaggery in the media produced the maximum pullulan content as 21.6, 19.7 and 18.6 g per 100 g of jaggery, respectively, used. A sucrose based defined media were also used for comparison purposes. Fourier Transform InfraRed (FTIR) spectroscopic analysis was done to confirm the functional groups of synthesized pullulan and compared with that of commercial pullulan.Shake-flask fermentation, under batch cultivation, was investigated for the production of fungal exopolysaccharide, pullulan using jaggery (a traditional concentrated sugar cane juice) as a carbon substrate by Aureobasidium pullulans MTCC 2195. Change in the initial pH (from 3.0 to 7.0) of media containing jaggery was varied to study the effect of pH in the fermentation and maximum pullulan yield was obtained at a pH of 5.0. An increase in the initial concentrations (50, 75, 100 g/L) of jaggery in the media produced the maximum pullulan content as 21.6, 19.7 and 18.6 g per 100 g of jaggery, respectively, used. A sucrose based defined media were also used for comparison purposes. Fourier Transform InfraRed (FTIR) spectroscopic analysis was done to confirm the functional groups of synthesized pullulan and compared with that of commercial pullulan

HNF4α isoforms: the fraternal twin master regulators of liver function

In the more than 30 years since the purification and cloning of Hepatocyte Nuclear Factor 4 (HNF4α), considerable insight into its role in liver function has been gleaned from its target genes and mouse experiments. HNF4α plays a key role in lipid and glucose metabolism and intersects with not just diabetes and circadian rhythms but also with liver cancer, although much remains to be elucidated about those interactions. Similarly, while we are beginning to elucidate the role of the isoforms expressed from its two promoters, we know little about the alternatively spliced variants in other portions of the protein and their impact on the 1000-plus HNF4α target genes. This review will address how HNF4α came to be called the master regulator of liver-specific gene expression with a focus on its role in basic metabolism, the contributions of the various isoforms and the intriguing intersection with the circadian clock

Modelling and optimization of an off-grid hybrid renewable energy system for electrification in a rural areas

Energy required by remote village areas can be met quite reliably by hybrid energy technologies. The project under consideration is for electrifying a group of three villages in Kollegal block of Chamarajanagar district, Karnataka State in India using an off-grid hybrid renewable energy system. The process of optimizing such hybrid energy system control, sizing and choice of components is to provide it with a cost effective power solution for the society. The main objective of this paper is to reduce the Total System Net Preset Cost (TNPC), Cost of Energy (COE), unmet load, CO2 emissions using Genetic Algorithm (GA) and HOMER Pro Software. The results of the two methods are compared with four combinations of hybrid renewable energy systems (HRES). A sensitivity analysis is also performed on the best possible solution to the study for changes in annual wind speed and biomass fuel prices. Finally, a comparative analysis is performed between the GA and HOMER. Compared to HOMER, GA based HRES of combination-1( biogas+biomass+solar+ wind+ fuel cell with battery) is found to be the optimal solution supplying energy with 0% unmet load at the least cost of energy, which is at $ 0.163 per KWH. Thus PV saturation in GA is more cost effective than the HOMER

Goertzel Algorithm Based Islanding Detection Method Based on Small Second Order Harmonic Component for Grid Integrated PV Systems

782-787In modern power system many challenges have beenoccur when the distribution generation (DG) integrating to the power grid. One of the major challenges is islanding phenomena, which occurs when the power grid disconnected from the distribution system and disconnected power line still supplied by the DG system. This unintentional phenomenon must be detected to prevent the damage to equipment and hazardous effects to the workers. Active methods have small non-detection zone (NDZ). This paper proposes a new islanding detection method (IDM) based on injecting the harmonic component and monitoring the changes in power system by reducing the islanding detection time and zero crossing effect of the system. A new algorithm is introduced to detect islanding condition. The advantage of using Goertzel Algorithm (GA) is reducing the total number of computational effort.The proposed islanding detection method is small detection time compared to the other techniques.This paper simulate by using the MATLAB/SIMULINK

Anterior fixed interim prosthesis with natural tooth crown as pontic subsequent to replantation failure

Facial trauma resulting in tooth avulsion results in problems of physical and emotional nature for the patient and a challenge for the dentist. Avulsion accounts for 0.5–16% of traumatic injuries in the permanent dentition that can occur at any age and is most common in the young permanent dentition. As an emergency procedure, it is advisable to replant a traumatically avulsed tooth, but unfortunately long-term success is rather low. After unsuccessful replantation and subsequent extraction, it is prudent to replace the lost tooth to avoid aesthetic, masticatory, and psychological difficulties and also to prevent arch length discrepancy with various alternatives are available for the same. We presented a method for management of one of the two replanted teeth that showed failure, using the natural crown as pontic in a fixed semi-permanent bridge until a more definitive prosthesis can be fabricated at a later age for better patient compliance

Detection of Xanthomonas oryzae pv oryzae in BLB Paddy Seed Samples from Endemic Regions of Telangana State, India

Bacterial Leaf Blight disease (BLB) in rice caused by Xanthomonas oryzae pv oryzae (Xoo), is one of the most economically important diseases causing epidemics globally, resulting in severe crop losses of 50% in addition to affecting the seed quality in Asia. In the present study, ten BLB affected paddy seed samples were collected during Kharif, 2021-22 from the farmer's fields of major BLB endemic districts viz., Nizamabad and Khammam of Telangana state. The collected BLB seed samples were subjected to different standard seed health tests (ISTA, 1996) for detection and isolation of Xoo. Among the different methods evaluated, the detection of Xoo from BLB affected seed samples was high in the Agar plate method followed by the test tube water agar method. However, the component plating method revealed that, of the different seed components, the per cent recovery of Xoo was high from the embryo followed by lemma, palea and endosperm indicating the systemic type of infection of Xoo. Further, the results of the paper towel method stated that of the ten BLB affected paddy seed samples collected, the seed samples of Govuru village (Nizamabad district) and Rejarla village (Khammam district) have recorded below Indian Minimum Seed Certification Standards i.e 77.00% and 79.25% of per cent seed germination compared to the seed samples of other locations