ANTROPOMETRIC COMPARISONS IN TYPE 2 DIABETES PATIENTS, RELATED TO POPULATIONS WITH DIFFERENT SOCIAL EXPERIENCE

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Additional Impact of Glucose Tolerance on Telomere Length in Persons With and Without Metabolic Syndrome in the Elderly Ukraine Population

Rationale: Association between different components of metabolic syndrome and the rate of age-related telomere shortening was reported repeatedly, although some findings are inconsistent across studies, suggesting the need for further research on the topic. In the present study, we examined relationships between different components of metabolic syndrome (MetS); glucose tolerance reflected in 2-h post-load plasma glucose (2hPG) levels and age on the leukocyte telomere length (LTL) in Ukraine population.Methods: The study was conducted on the 115 adult individuals residing in the Kyiv region (Ukraine). Among them, 79 were diagnosed with MetS according to the International Diabetes Federation definition. LTL were determined by a qPCR-based method. Multivariate logistic regression (MLR) and artificial neural networks (ANN) modeling were used for the analysis of the results. ROC-analysis was also performed to compare the predictively values of this models.Results: MetS was associated with a high (OR = 3.0 CI 1.3–6.7; p = 0.01) risk of having shorter telomeres that remained significant after adjusting for age, gender and 2hPG levels. Fasting plasma glucose (FPG) levels and other MetS components did not affect the magnitude of the relationship and did not reveal the independent influence of these factors. The level of 2hPG in turn, demonstrated a significant relationship (OR = 1.3 CI 1.0–1.6 per 1 mmol/l; p = 0.04) with LTL regardless of the presence of MetS. The non-linearity of the interactions between age, gender and 2hPG level was revealed by neural network modeling (AUC = 0.76 CI 0.68–0.84).Conclusion: Our study found that impaired glucose tolerance, but not FPG levels, affected the association between LTL and MetS, which may be also indicative for pathophysiological differences in these hyperglycemia categories. 2hPG levels can provide an opportunity for a more accurate diagnostics of MetS and for evaluating the rate of aging in patients with MetS. Further research, however, is needed to verify this assumption

Black Sea tele-diab: Development and implementation of an electronic patient record for patients with diabetes

Black Sea tele-diab (BSTD) is a three-year European Union (EU)-funded International Collaboration (INCO) Telematics Application Project to develop a standardized software package (in the national languages of the partners) for the storage and transfer of medical information collected from patients with diabetes. The software utilizes an electronic medical record architecture based on the Good European Health Record, developed within the Advanced Informatics in Medicine programme. Software development is being carried out by the partners in Eastern Europe, which will help promote the development of medical informatics and communication technologies among countries of Central Europe (CCE) and newly independent states (NIS) countries. The diabetes data set is based on the WHO Europe DiabCare Basic Information Sheet; the project therefore supports the World Health Organisation (WHO) Quality Care Programme for monitoring the prevalence and incidence of diabetic complications across Europe. Diabetes is used as a model, as standards for data collection and clinical care are well developed and the concepts applied and learnt in diabetes will be generally applicable to other chronic diseases and medical disciplines. © 2001, Sage Publications. All rights reserved