Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop

In 1993, Przyklenk and colleagues made the intriguing experimental observation that 'brief ischemia in one vascular bed also protects remote, virgin myocardium from subsequent sustained coronary artery occlusion' and that this effect '.... may be mediated by factor(s) activated, produced, or transported throughout the heart during brief ischemia/reperfusion'. This seminal study laid the foundation for the discovery of 'remote ischemic conditioning' (RIC), a phenomenon in which the heart is protected from the detrimental effects of acute ischemia/reperfusion injury (IRI), by applying cycles of brief ischemia and reperfusion to an organ or tissue remote from the heart. The concept of RIC quickly evolved to extend beyond the heart, encompassing inter-organ protection against acute IRI. The crucial discovery that the protective RIC stimulus could be applied non-invasively, by simply inflating and deflating a blood pressure cuff placed on the upper arm to induce cycles of brief ischemia and reperfusion, has facilitated the translation of RIC into the clinical setting. Despite intensive investigation over the last 20 years, the underlying mechanisms continue to elude researchers. In the 8th Biennial Hatter Cardiovascular Institute Workshop, recent developments in the field of RIC were discussed with a focus on new insights into the underlying mechanisms, the diversity of non-cardiac protection, new clinical applications, and large outcome studies. The scientific advances made in this field of research highlight the journey that RIC has made from being an intriguing experimental observation to a clinical application with patient benefit

An SNR-assisted crosstalk channel estimation technique

In this paper, we present a new method to estimate the crosstalk channels in VDSL systems, allowing to implement well-known pre-compensation schemes. As opposed to previously presented methods, this estimation only requires minimal changes to the current standard and equipments. It is based on the concept of adding small, controlled, perturbations to the transmitted signal and observing the related changes to the SNR at the receiver. It is shown in this paper that, based on a limited amount of SNR measurements from the receivers, it is possible to accurately estimate the crosstalk channels, both in amplitude and phase.Anglai

Constrained Laplacian Score for Semi-supervised Feature Selection

International audienceIn this paper, we address the problem of semi-supervised feature selection from high-dimensional data. It aims to select the most discriminative and informative features for data analysis. This is a recent addressed challenge in feature selection research when dealing with small labeled data sampled with large unlabeled data in the same set. We present a filter based approach by constraining the known Laplacian score. We evaluate the relevance of a feature according to its locality preserving and constraints preserving ability. The problem is then presented in the spectral graph theory framework with a study of the complexity of the proposed algorithm. Finally, experimental results will be provided for validating our proposal in comparison with other known feature selection methods