412 research outputs found
Application of Photovoice with Focus Groups to Explore Dietary Behaviors of Older Filipino Adults with Cardiovascular Disease
Filipino Americans have high rates of cardiovascular diseases (CVD). This study explored the dietary behaviors, a modifiable risk factor, of Filipinos with CVD. Filipinos with CVD were recruited and trained to do Photovoice. Participants took photos to depict their “food experience,” defined as their daily dietary activities. Participants then shared their photos during focus groups. Focus group transcripts were analyzed using an iterative, grounded theory approach. Among 38 Filipino participants, the mean age was 70 years old and all were foreign-born. Major themes included efforts to retain connection to Filipino culture through food, and dietary habits shaped by cultural health beliefs. Many believed that traditional dietary practices increased CVD risk. Receiving a CVD diagnosis and clinician advice changed their dietary behaviors. Household members, the physical environment, and economic constraints also influenced dietary behaviors. Photovoice is feasible among older Filipinos and may enhance understanding of drivers of dietary behaviors
Hysteresis and the dynamic phase transition in thin ferromagnetic films
Hysteresis and the non-equilibrium dynamic phase transition in thin magnetic
films subject to an oscillatory external field have been studied by Monte Carlo
simulation. The model under investigation is a classical Heisenberg spin system
with a bilinear exchange anisotropy in a planar thin film geometry with
competing surface fields. The film exhibits a non-equilibrium phase transition
between dynamically ordered and dynamically disordered phases characterized by
a critical temperature Tcd, whose location of is determined by the amplitude H0
and frequency w of the applied oscillatory field. In the presence of competing
surface fields the critical temperature of the ferromagnetic-paramagnetic
transition for the film is suppressed from the bulk system value, Tc, to the
interface localization-delocalization temperature Tci. The simulations show
that in general Tcd < Tci for the model film. The profile of the time-dependent
layer magnetization across the film shows that the dynamically ordered and
dynamically disordered phases coexist within the film for T < Tcd. In the
presence of competing surface fields, the dynamically ordered phase is
localized at one surface of the film.Comment: PDF file, 21 pages including 8 figure pages; added references,typos
added; to be published in PR
Four Levels of Hierarchical Organization, Including Noncovalent Chainmail, Brace the Mature Tumor Herpesvirus Capsid against Pressurization
SummaryLike many double-stranded DNA viruses, tumor gammaherpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus withstand high internal pressure. Bacteriophage HK97 uses covalent chainmail for this purpose, but how this is achieved noncovalently in the much larger gammaherpesvirus capsid is unknown. Our cryoelectron microscopy structure of a gammaherpesvirus capsid reveals a hierarchy of four levels of organization: (1) Within a hexon capsomer, each monomer of the major capsid protein (MCP), 1,378 amino acids and six domains, interacts with its neighboring MCPs at four sites. (2) Neighboring capsomers are linked in pairs by MCP dimerization domains and in groups of three by heterotrimeric triplex proteins. (3) Small (∼280 amino acids) HK97-like domains in MCP monomers alternate with triplex heterotrimers to form a belt that encircles each capsomer. (4) One hundred sixty-two belts concatenate to form noncovalent chainmail. The triplex heterotrimer orchestrates all four levels and likely drives maturation to an angular capsid that can withstand pressurization
Melanotic oncocytic metaplasia of the nasopharynx as a benign mimicker of malignant melanoma: a case report
<p>Abstract</p> <p>Introduction</p> <p>Melanotic variant of oncocytic metaplasia of the nasopharynx is an extremely rare condition.</p> <p>Case report</p> <p>A 73-year-old Japanese man presented with nasal congestion and chill. Nasoscopic examination revealed multiple black nodules around the bilateral torus tubarius. The nodules were biopsied to determine the histology. The clinical differential diagnosis was malignant melanoma or hemangioma. Microscopically, there were oncocytic plump cells with abundant brown pigmented granules showing glandular pattern. No significant atypia was found. The pigment was positive for Fontana-Masson staining, and negative for Berlin blue staining, showing that it was melanin pigment. Immunohistochemically, S100-positive HMB45-negative dendritic cells were also found.</p> <p>Conclusion</p> <p>Such a pigmented variant of benign oncocytic lesion is very rare, and only 15 cases have been reported in the English literature. As a benign mimicker of malignant melanoma, melanocytic oncocytic metaplasia should be always taken into consideration in the clinical setting.</p
Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila
In eye development the tasks of tissue specification and cell proliferation are regulated, in part, by the Pax6 and Pax6(5a) proteins respectively. In vertebrates, Pax6(5a) is generated as an alternately spliced isoform of Pax6. This stands in contrast to the fruit fly, Drosophila melanogaster, which has two Pax6(5a) homologs that are encoded by the eyegone and twin of eyegone genes. In this report we set out to determine the respective contributions that each gene makes to the development of the fly retina. Here we demonstrate that both eyg and toe encode transcriptional repressors, are expressed in identical patterns but at significantly different levels. We further show, through a molecular dissection of both proteins, that Eyg makes differential use of several domains when compared to Toe and that the number of repressor domains also differs between the two Pax6(5a) homologs. We predict that these results will have implications for elucidating the functional differences between closely related members of other Pax subclasses
Anterior-inferior plating of middle-third fractures of the clavicle
© The Author(s) 2009. This article is published with open access at Springerlink.com Introduction Various techniques have been reported for the treatment of middle-third clavicle (collar bone) fractures. This prospective study was conducted to evaluate the results of anterior-inferior plating using a 3.5-mm reconstruction plate for the treatment of middle-third clavicle fractures
Dynamic phase transitions in thin ferromagnetic films
Monte Carlo simulations have been used to investigate the dynamic phase
behavior of a classical Heisenberg spin system with a bilinear exchange
anisotropy in a planar thin film geometry. Studies of the field amplitude,
frequency and temperature dependence show dynamic phase transitions in films
subject to a pulsed oscillatory external field. Thin films with competing
surface fields show separate and distinct dynamic phase transitions for the
bulk and surface layers of the film. Between the two transitions, a mixed state
with coexisting dynamically ordered and dynamically disordered phases is
observed in the film. In contrast, the free film with no surface fields shows a
single dynamic phase transition as in a bulk system.Comment: 25 pages including figures in pdf format, to be published in PR
The Utility of the Abstract Relational Model and Attribute Paths in SQL
It is well-known that querying information is difficult for domain experts, for they are not familiar with querying actual relational schemata due to the notions of primary and foreign keys and the various ways of representing and storing information in a relational database. To overcome these problems, the Abstract Relational Model and the query language, SQLP, have been proposed. They are the theoretical foundations and ensure that explicit primary and foreign keys are hidden from the user's view and that queries can be expressed more compactly. In this paper we evaluate these theoretical advantages with user studies that compare SQLP to plain SQL as the baseline. The experiments show significant statistical evidence that SQLP indeed requires less time for understanding and authoring queries, with no loss in accuracy. Considering the positive results, we develop a method to reverse engineer legacy relational schemata into abstract relational ones
Liquid Flyback Booster Pre-Phase A Study Assessment
Mw concept of a flyback booster has been around since early in the Shuttle program. The original two-stage Shuttle concepts used a manned flyback booster. These boosters were eliminated from the program for funding and size reasons. The current Shuttle uses two Redesigned Solid Rocket Motors (RSRMs), which are recovered and refurbished after each flight; this is one of the major cost factors of the program. Replacement options have been studied over the past ten years. The conclusion reached by the most recent study is that the liquid flyback booster (LFBB) is the only competitive option from a life-cycle cost perspective. The purpose of this study was to assess the feasibility and practicality of LFBBs. The study provides an expansion of the recommendations made during the during the aforementioned study. The primary benefits are the potential for enhanced reusability and a reuction of recurring costs. The potential savings in vehicle turnaround could offset the up-front costs. Development of LFBBs requires a commitment to the Shuttle program for 20 to 30 years. LFBBs also offer enhanced safety and abort capabilities. Currently, any failure of an RSRM can be considered catastrophic since them we no intact abort capabilities during the burn of the RSRMS. The performance goal of the LFBBs was to lift a fully loaded Orbiter under optimal conditions, so as not to be the limiting factor of the performance capability of the Shuttle. In addition, a final benefit is the availability of growth paths for applications other than the Shuttle
An iron detection system determines bacterial swarming initiation and biofilm formation
Iron availability affects swarming and biofilm formation in various bacterial species. However, how bacteria sense iron and coordinate swarming and biofilm formation remains unclear. Using Serratia marcescens as a model organism, we identify here a stage-specific iron-regulatory machinery comprising a two-component system (TCS) and the TCS-regulated iron chelator 2-isocyano-6,7-dihydroxycoumarin (ICDH-Coumarin) that directly senses and modulates environmental ferric iron (Fe3+) availability to determine swarming initiation and biofilm formation. We demonstrate that the two-component system RssA-RssB (RssAB) directly senses environmental ferric iron (Fe3+) and transcriptionally modulates biosynthesis of flagella and the iron chelator ICDH-Coumarin whose production requires the pvc cluster. Addition of Fe3+, or loss of ICDH-Coumarin due to pvc deletion results in prolonged RssAB signaling activation, leading to delayed swarming initiation and increased biofilm formation. We further show that ICDH-Coumarin is able to chelate Fe3+ to switch off RssAB signaling, triggering swarming initiation and biofilm reduction. Our findings reveal a novel cellular system that senses iron levels to regulate bacterial surface lifestyle
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