3,357 research outputs found

    Search for a light charged Higgs boson in the decay channel H^+→cs in tt events using pp collisions at s√=7 TeV with the ATLAS detector

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    A search for a charged Higgs boson (H^+) in tt decays is presented, where one of the top quarks decays via t→H^+ b, followed by H^+→ two jets (cs). The other top quark decays to Wb, where the W boson then decays into a lepton (e/μ) and a neutrino. The data were recorded in pp collisions at s√=7 TeV by the ATLAS detector at the LHC in 2011, and correspond to an integrated luminosity of 4.7 fb^(−1). With no observation of a signal, 95 % confidence level (CL) upper limits are set on the decay branching ratio of top quarks to charged Higgs bosons varying between 5 % and 1 % for H^+ masses between 90 GeV and 150 GeV, assuming B(H^+→cs)=100%

    Solar energy research and development program on the exploitation of the solar resource on the Reunion Island and its integration into an electrical power grid

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    Paper presented to the 3rd Southern African Solar Energy Conference, South Africa, 11-13 May, 2015.Reunion Island stands out by its specific energy context due to its growing population and a strong economic development. The main objective of this French region is to ensure that its exceptional potential for renewable power generation could meet an increasing energy demand. Regarding the energy development, the Regional strategy is to reach the energy independence by 2030 (SPL “Energies Réunion”) without using fossil fuels. In this context, the LE2P is leading a solar resource research programme with the aim to use solar resource as a stable source of energy and ensure its management in a reliable and efficient way for its integration into an electrical power grid. This paper aims to describe the methodology used for the development of this ambitious and challenging R&D program, projects articulation within the LE2P roadmap’s and the collaborations and partnerships initiated in UE and OI zone, permitting Eco city development especially in the IO area.cf201

    Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models

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    Background: Zebrafish is a clinically-relevant model of heart regeneration. Unlike mammals, it has a remarkable heart repair capacity after injury, and promises novel translational applications. Amputation and cryoinjury models are key research tools for understanding injury response and regeneration in vivo. An understanding of the transcriptional responses following injury is needed to identify key players of heart tissue repair, as well as potential targets for boosting this property in humans. Results: We investigated amputation and cryoinjury in vivo models of heart damage in the zebrafish through unbiased, integrative analyses of independent molecular datasets. To detect genes with potential biological roles, we derived computational prediction models with microarray data from heart amputation experiments. We focused on a top-ranked set of genes highly activated in the early post-injury stage, whose activity was further verified in independent microarray datasets. Next, we performed independent validations of expression responses with qPCR in a cryoinjury model. Across in vivo models, the top candidates showed highly concordant responses at 1 and 3 days post-injury, which highlights the predictive power of our analysis strategies and the possible biological relevance of these genes. Top candidates are significantly involved in cell fate specification and differentiation, and include heart failure markers such as periostin, as well as potential new targets for heart regeneration. For example, ptgis and ca2 were overexpressed, while usp2a, a regulator of the p53 pathway, was down-regulated in our in vivo models. Interestingly, a high activity of ptgis and ca2 has been previously observed in failing hearts from rats and humans. Conclusions: We identified genes with potential critical roles in the response to cardiac damage in the zebrafish. Their transcriptional activities are reproducible in different in vivo models of cardiac injury. Electronic supplementary material The online version of this article (doi:10.1186/1471-2164-15-852) contains supplementary material, which is available to authorized users
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