Formulation Development and Evaluation of Valsartan Film Coated Tablets

Solid medicaments may be administered orally as powders, pills, cachets, capsules or tablets. These dosage forms contain a quantity of drug which is given as a single unit and they are known collectively as solid unit dosage forms, even in the case of sustained action preparations which, technically, contain the equivalent of several normal doses of drug .The stringent formulation requirements of modern medicaments, the many advantages of tablet and capsule medication, coupled with expanding health services and the commitment need for large-scale economic manufacture, have led to a steady decline in the prescribing of powders and pills. Tablets and capsules, on the other hand, currently account for well over two third of the total number and cost of medicines produced all over the world. The valsartan film coated tablets have been developed with direct compression method and it was compared with that of marketed product. The powder blend were subject to various physical characteristics tests such as bulk density, tapped density, Hausners ratio, compressibility index and core tablets were evaluated for weight variation, hardness, thickness, disintegration time and the results were within specification. In-vitro dissolution profile of developed formula was compared with marketed product and drug release profile of formula 8 was found to be matched with marketed product. The combination of superdisintegrants, crosscarmellose and cropovidone was shown faster disintegration rate. The optimized batch tablets were packed in HDPE bottle and performed stability studies at 40°C/75%RH. Stability samples were evaluated initially and upto three months. All the results were found to be satisfactory. Hence the designed and developed formula was stable. Valsartan film coated tablet developed in the present work was found to be pharmaceutically equivalent to marketed product

N- Graphene Derivatives from Papaya Seeds: Synthesis and Chemistry

246-249A two-step synthesis of nitrogen containing graphene (N-graphene) from papaya seeds is reported here. The preparation of N-graphene from a non-graphitic nitrogen containing precursor, without doping is really a challenging task. However, when papaya seeds were pyrolyzed at 250 oC temperature for 2 hrs, it led to the formation of N-GO without any additional oxidizing agent. Further, N-GO was converted to Nr-GO in presence of thiourea as a reducing agent. The synthesized N-GO was found to remove 82 % of iron from ground water

CHITOSAN NANOBUBBLES DEVELOPMENT AND EVALUATION FOR THE DELIVERY OF SUNITINIB-AN ANTICANCER AGENT

Objective: In the current study, we introduced a novel method for creating Sunitinib nanobubbles by incorporating it into chitosan-shelled nanobubbles. Methods: The Design Expert® programme randomly assigned around 13 experiments, and multiple regression analysis was used to statistically examine the data. The effect of the amount of sunitinib, amount of chitosan, amount of Epikuron 200, amount of palmitic acid and stirring speed, on percent encapsulation efficiency and drug load while maintain minimum particle size of nanobubbles as considered through a definitive screening plan. By placing limitations on the response parameters, the optimum formulation was created using a numerical optimization approach. The three improved formulations (Batch1 through Batch3) were assessed. Results: The findings show that the nanobubbles particle size of 78.56-82.42 nm with an encapsulation efficiency of 68.48-69.56 % and loading capacity of 23.88-25.02%. The quantity of sunitinib released from nanobubbles was much larger (96.52 percent) than that from the sunitinib solution within 24 h, according to an in vitro release profile of the medication using ultrasonography. The hemolytic activity of the blank nanobubbles and sunitinib-loaded nanobubbles was measured to assess their safety up to a concentration of 10 mg/ml. With erythrocytes, drug-loaded nanobubbles had a good safety profile. FTIR, DSC studies indicated no chemical interactions, TEM images revealed nanobubbles size of 70-100 nm and stability studies shows no significant changes. Conclusion: For contrast-enhanced tumour imaging and subsequent therapeutic administration, nanobubbles were found to be superior

Securing Manets By Using An Intrusion Detection System (Eaack)

MANET arrangement may diverge depending on its application from a small static network that is extremely power inhibited to a large-scale, mobile, highly dynamic network. Every node works both as a transmitter and a receiver. Nodes converse directly with each other when they are both within the same communication range. Otherwise they depend on their neighbours to relay messages. Industrial remote access and control via wireless networks are flattering more and more popular these days. One of the chief advantages of wireless networks is its capability to permit data communication between different parties and still maintain their mobility. This communication is incomplete to the range of transmitters. This means that two nodes cannot communicate with each other when the distance between the two nodes is further than the communication range of their own. MANET solves this problem by allowing intermediate nodes to rely data transmission.   In this case detection should be focused as another part before an attacker can damage the structure of the system

N- Graphene Derivatives from Papaya Seeds: Synthesis and Chemistry

A two-step synthesis of nitrogen containing graphene (N-graphene) from papaya seeds is reported here. The preparation of N-graphene from a non-graphitic nitrogen containing precursor, without doping is really a challenging task. However, when papaya seeds were pyrolyzed at 250 oC temperature for 2 hrs, it led to the formation of N-GO without any additional oxidizing agent. Further, N-GO was converted to Nr-GO in presence of thiourea as a reducing agent. The synthesized N-GO was found to remove 82 % of iron from ground water

ANTIBACTERIAL ACTIVITY OF SOME FOLKLORE MEDICINAL PLANTS FROM SOUTH INDIA

Antibacterial activity and phytochemical tests of eight whole plant methanol extracts belonging to family Euphorbiaceae were evaluated. In agar well diffusion assay the diameter of inhibition zones ranged from 3-13 mm. Phyllanthus emblica showed maximum activity of 13 mm. The MIC and MBC observed were 30-140 mcg/ml and 40-160 mcg/ml, respectively. P. piscatorum and P. emblica showed the lowest MIC (30 mcg/ml), P. emblica the lowest MBC (40 mcg/ml) and thus an effective inhibitor of the tested bacteria. Alkaloids, saponins and tannins were detected in 7 out of 8 tested plants

Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage.

Alcoholic fatty liver disease (AFLD) is characterized by lipid accumulation and inflammation and can progress to cirrhosis and cancer in the liver. AFLD diagnosis currently relies on histological analysis of liver biopsies. Early detection permits interventions that would prevent progression to cirrhosis or later stages of the disease. Herein, we have conducted the first comprehensive time-course study of lipids using novel state-of-the art lipidomics methods in plasma and liver in the early stages of a mouse model of AFLD, i.e., Lieber-DeCarli diet model. In ethanol-treated mice, changes in liver tissue included up-regulation of triglycerides (TGs) and oxidized TGs and down-regulation of phosphatidylcholine, lysophosphatidylcholine, and 20-22-carbon-containing lipid-mediator precursors. An increase in oxidized TGs preceded histological signs of early AFLD, i.e., steatosis, with these changes observed in both the liver and plasma. The major lipid classes dysregulated by ethanol play important roles in hepatic inflammation, steatosis, and oxidative damage. Conclusion: Alcohol consumption alters the liver lipidome before overt histological markers of early AFLD. This introduces the exciting possibility that specific lipids may serve as earlier biomarkers of AFLD than those currently being used