460 research outputs found
ROSAT Evidence for Intrinsic Oxygen Absorption in Cooling Flow Galaxies and Groups
Using spatially resolved, deprojected ROSAT PSPC spectra of 10 of the
brightest cooling flow galaxies and groups with low Galactic column densities
we have detected intrinsic absorption over energies ~0.4-0.8 keV in half of the
sample. Since no intrinsic absorption is indicated for energies below ~0.4 keV,
the most reasonable model for the absorber is collisionally ionized gas at
temperatures T=10^{5-6} K with most of the absorption arising from ionized
states of oxygen but with a significant contribution from carbon and nitrogen.
The soft X-ray emission of this warm gas can explain the sub-Galactic column
densities of cold gas inferred within the central regions of most of the
systems. Attributing the absorption to ionized gas reconciles the large columns
of cold H and He inferred from EINSTEIN and ASCA with the lack of such columns
inferred from ROSAT. Within the central ~10-20 kpc, where the constraints are
most secure, the estimated mass of the ionized absorber is consistent with most
(perhaps all) of the matter deposited by a cooling flow over the lifetime of
the flow. Since the warm absorber produces no significant H or He absorption
the large absorber masses are consistent with the negligible atomic and
molecular H inferred from HI and CO observations of cooling flows. It is also
found that if T > ~2x10^5 K then the optical and UV emission implied by the
warm gas does not violate published constraints. Finally, we discuss how the
prediction of warm ionized gas as the product of mass drop-out in these and
other cooling flows can be verified with new CHANDRA and XMM observations.
(Abridged)Comment: 17 pages (5 figures), Accepted for publication in ApJ, expanded
discussion of multiphase spectral models, theoretical implications of warm
gas in cooling flows, and the statistical significance of the oxygen
absorptio
The Extended Blue Continuum and Line Emission around the Central Radio Galaxy in Abell 2597
We present results from detailed imaging of the centrally dominant radio
elliptical galaxy in the cooling flow cluster Abell 2597, using data obtained
with the Wide Field and Planetary Camera 2 (WFPC2) on the Hubble Space
Telescope (HST). This object is one of the archetypal "blue-lobed" cooling flow
radio elliptical galaxies, also displaying a luminous emission-line nebula, a
compact radio source, and a significant dust lane and evidence of molecular gas
in its center. We show that the radio source is surrounded by a complex network
of emission-line filaments, some of which display a close spatial association
with the outer boundary of the radio lobes. We present a detailed analysis of
the physical properties of ionized and neutral gas associated with the radio
lobes, and show that their properties are strongly suggestive of direct
interactions between the radio plasma and ambient gas. We resolve the blue
continuum emission into a series of knots and clumps, and present evidence that
these are most likely due to regions of recent star formation. We investigate
several possible triggering mechanisms for the star formation, including direct
interactions with the radio source, filaments condensing from the cooling flow,
or the result of an interaction with a gas-rich galaxy, which may also have
been responsible for fueling the active nucleus. We propose that the properties
of the source are plausibly explained in terms of accretion of gas by the cD
during an interaction with a gas-rich galaxy, which combined with the fact that
this object is located at the center of a dense, high-pressure ICM can account
for the high rates of star formation and the strong confinement of the radio
source.Comment: Astrophysical Journal, in press, 34 pages, includes 6 PostScript
figures. Latex format, uses aaspp4.sty and epsf.sty file
Dental students’ perceptions of learning communication skills in a forum theatre-style teaching session on breaking bad news
Introduction: Communication skills are an integral component of dental undergraduate education. Due to the complex nature of these skills, didactic teaching methods used in other educational contexts can be limited. Interactive and participative methods rooted in modern adult learning theories, such as Forum Theatre, may be more effective in the teaching of communication skills. Aim: To explore the usefulness of Forum Theatre in teaching clinical undergraduate dental students how to break bad news to their patients.Methods: A purposive sample of 4th-year undergraduate dental students was invited to participate. An evaluation questionnaire was given to the students and collected after the Forum Theatre interactive session. Participants were asked to provide self-reported accounts on the most and least useful parts of the session, as well as the most important learning outcome. Usefulness of the session in clinical work, increasing confidence and ability in breaking bad news, were evaluated via a 5-point Likert-scale type question. Qualitative data were analysed using Framework Analysis to explore the themes found in the open-text component. Descriptive statistics were used to analyse the Likert-scale items.Results: One hundred and fifteen completed questionnaires were collected from the 2015 and 2016 classes. Most students gave the Forum Theatre session a rating of 3 or above on a 5-point Likert scale; indicating that they found it useful. Qualitative results also showed that most participants liked the teaching session thanks to its interactive nature, the use of actors and the input of the facilitators. The majority of students showed preference towards smaller groups which give everyone equal opportunity to participate without unnecessary repetition.Conclusion: The results seem to confirm previous findings. Students rated their learning experience involving Forum Theatre favourably. Smaller groups and trained facilitators are required for the success of this teaching method. Further research is needed to assess the long-term educational benefits of Forum Theatre.</p
Formation of Low Mass Stars in Elliptical Galaxy Cooling Flows
X-ray emission from hot (T = 10^7 K) interstellar gas in massive elliptical
galaxies indicates that 10^{10} M_sun has cooled over a Hubble time, but
optical and radio evidence for this cold gas is lacking. We provide detailed
theoretical support for the hypothesis that this gas has formed into low
luminosity stars. Within several kpc of the galactic center, interstellar gas
first cools to T = 10^4 K where it is heated by stellar UV and emits the
observed diffuse optical line emission. This cooling occurs at a large number
(10^6) of isolated sites. After less than a solar mass of gas has accumulated
(10^{-6} M_sun/yr) at a typical cooling site, a neutral (HI or H_2) core
develops in the HII cloud where gas temperatures drop to T = 15 K and the
ionization level (from thermal X-rays) is very low (x = 10^{-6}). We show that
the maximum mass of cores that become gravitationally unstable is only about 2
M_sun. No star can exceed this mass. Fragmentation of collapsing cores produces
a population of low mass stars with a bottom-heavy IMF and radial orbits.
Gravitational collapse and ambipolar diffusion are rapid. The total mass of
star-forming (dust-free) HI or H_2 cores in a typical bright elliptical is only
10^6 M_sun, below current observational thresholds.Comment: 23 pages in AASTEX LaTeX with 8 figures; accepted by Astrophysical
Journa
On the Internal Absorption of Galaxy Clusters
A study of the cores of galaxy clusters with the Einstein SSS indicated the
presence of absorbing material corresponding to 1E+12 Msun of cold cluster gas,
possibly resulting from cooling flows. Since this amount of cold gas is not
confirmed by observations at other wavelengths, we examined whether this excess
absorption is present in the ROSAT PSPC observations of 20 bright galaxy
clusters. For 3/4 of the clusters, successful spectral fits were obtained with
absorption due only to the Galaxy, and therefore no extra absorption is needed
within the clusters, in disagreement with the results from the Einstein SSS
data for some of the same clusters. For 1/4 of the clusters, none of our
spectral fits was acceptable, suggesting a more complicated cluster medium than
the two-temperature and cooling flow models considered here. However, even for
these clusters, substantial excess absorption is not indicated.Comment: accepted by the Astrophysical Journa
Long-Term Survival after Gamma Knife Radiosurgery in a Case of Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature
The management of recurrent glioblastoma is highly challenging, and treatment outcomes remain uniformly poor. Glioblastoma is a highly infiltrative tumor, and complete surgical resection of all microscopic extensions cannot be achieved at the time of initial diagnosis, and hence local recurrence is observed in most patients. Gamma Knife radiosurgery has been used to treat these tumor recurrences for select cases and has been successful in prolonging the median survival by 8–12 months on average for select cases. We present the unique case of a 63-year-old male with multiple sequential recurrences of glioblastoma after initial standard treatment with surgery followed by concomitant external beam radiation therapy and chemotherapy (temozolomide). The patient was followed clinically as well as with surveillance MRI scans at every 2-3-month intervals. The patient underwent Gamma Knife radiosurgery three times for 3 separate tumor recurrences, and the patient survived for seven years following the initial diagnosis with this aggressive treatment. The median survival in patients with recurrent glioblastoma is usually 8–12 months after recurrence, and this unique case illustrates that aggressive local therapy can lead to long-term survivors in select situations. We advocate that each patient treatment at the time of recurrence should be tailored to each clinical situation and desire for quality of life and improved longevity
Earliest land plants created modern levels of atmospheric oxygen
The progressive oxygenation of the Earth’s atmosphere was pivotal
to the evolution of life, but the puzzle of when and how
atmospheric oxygen (O2) first approached modern levels (~21%)
remains unresolved. Redox proxy data indicate the deep oceans
were oxygenated during 435-392 Ma, and the appearance of
fossil charcoal indicates O2>15-17% by 420-400 Ma. However,
existing models have failed to predict oxygenation at this time.
Here we show that the earliest plants, which colonized the land
surface from ~470 Ma onwards, were responsible for this mid-
Paleozoic oxygenation event, through greatly increasing global
organic carbon burial – the net long-term source of O2. We use
a trait-based ecophysiological model to predict that cryptogamic
vegetation cover could have achieved ~30% of today’s global
terrestrial net primary productivity by~445 Ma. Data from modern
bryophytes suggests this plentiful early plant material had a much
higher molar C:P ratio (~2000) than marine biomass (~100), such
that a given weathering flux of phosphorus could support more
organic carbon burial. Furthermore, recent experiments suggest
that early plants selectively increased the flux of phosphorus (relative
to alkalinity) weathered from rocks. Combining these effects
in a model of long-term biogeochemical cycling, we reproduce a
sustained +2‰ increase in the carbonate carbon isotope (δ13C)
record by ~445 Ma, and predict a corresponding rise in O2 to
present levels by 420-400 Ma, consistent with geochemical data.
This oxygen rise represents a permanent shift in regulatory regime
to one where fire-mediated negative feedbacks on organic carbon
burial stabilise high O2 levels
Regulation of the vapBC-1 Toxin-Antitoxin Locus in Nontypeable Haemophilus influenzae
Nontypeable Haemophilus influenzae (NTHi) are human-adapted commensal bacteria that can cause a number of chronic mucosal infections, including otitis media and bronchitis. One way for these organisms to survive antibiotic therapy and cause recurrent disease is to stop replicating, as most antimicrobials target essential biosynthetic pathways. Toxin-antitoxin (TA) gene pairs have been shown to facilitate entry into a reversible bacteriostatic state. Characteristically, these operons encode a protein toxin and an antitoxin that associate following translation to form a nontoxic complex, which then binds to and regulates the cognate TA promoter. Under stressful conditions, the labile antitoxin is degraded and the complex disintegrates, freeing the stable toxin to facilitate growth arrest. How these events affected the regulation of the TA locus, as well as how the transcription of the operon was subsequently returned to its normal state upon resumption of growth, was not fully understood. Here we show that expression of the NTHi vapBC-1 TA locus is repressed by a complex of VapB-1 and VapC-1 under conditions favorable for growth, and activated by the global transactivator Factor for Inversion Stimulation (Fis) upon nutrient upshift from stationary phase. Further, we demonstrate for the first time that the VapC-1 toxin alone can bind to its cognate TA locus control region and that the presence of VapB-1 directs the binding of the VapBC-1 complex in the transcriptional regulation of vapBC-1
Unique Neoproterozoic carbon isotope excursions sustained by coupled evaporite dissolution and pyrite burial
The Neoproterozoic era witnessed a succession of biological innovations that culminated in diverse animal body plans and behaviours during the Ediacaran–Cambrian radiations. Intriguingly, this interval is also marked by perturbations to the global carbon cycle, as evidenced by extreme fluctuations in climate and carbon isotopes. The Neoproterozoic isotope record has defied parsimonious explanation because sustained 12C-enrichment (low δ13C) in seawater seems to imply that substantially more oxygen was consumed by organic carbon oxidation than could possibly have been available. We propose a solution to this problem, in which carbon and oxygen cycles can maintain dynamic equilibrium during negative δ13C excursions when surplus oxidant is generated through bacterial reduction of sulfate that originates from evaporite weathering. Coupling of evaporite dissolution with pyrite burial drives a positive feedback loop whereby net oxidation of marine organic carbon can sustain greenhouse forcing of chemical weathering, nutrient input and ocean margin euxinia. Our proposed framework is particularly applicable to the late Ediacaran ‘Shuram’ isotope excursion that directly preceded the emergence of energetic metazoan metabolisms during the Ediacaran–Cambrian transition. Here we show that non-steady-state sulfate dynamics contributed to climate change, episodic ocean oxygenation and opportunistic radiations of aerobic life during the Neoproterozoic era
IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13
© 2008 Moynihan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
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