Adequate Breathing Space in a Poisonous Atmosphere: Balancing Freedom and Responsibility in the Open Society

The United States Supreme Court has invoked the first amendment as a constraint on state defamation actions, balancing the freedom of the press with the rights of individuals. The author examines the development of this balance and its purposes, and suggests that further limitation of the states\u27 power to protect its citizens may be harmful to both the press and the public

The 1973 Obscenity-Pornography Decisions: Analysis, Impact, and Legislative Alternatives

The purpose of this Article is to examine critically the rationale of those decisions and to assess their actual and potential impact. An exhaustive review of the history of obscenity in the courts is not contemplated nor necessary. Abler attempts at comprehensive treatment have, on occasion, been performed by members of the Court, as well as by scholars in the field. Constitutional history will be employed only insofar as it has a direct bearing upon the new guidelines announced by the Court and what one can expect from their subsequent application

Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster

BACKGROUND: Pancreatic cholesterol esterase has three proposed functions in the intestine: 1) to control the bioavailability of cholesterol from dietary cholesterol esters; 2) to contribute to incorporation of cholesterol into mixed micelles; and 3) to aid in transport of free cholesterol to the enterocyte. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. RESULTS: The selective and potent cholesterol esterase inhibitor 6-chloro-3-(1-ethyl-2-cyclohexyl)-2-pyrone (figure 1, structure 1) was administered to hamsters fed a high cholesterol diet supplemented with radiolabeled cholesterol ester. Hamsters were gavage fed (3)H-labeled cholesteryl oleate along with inhibitor 1, 0–200 micromoles. Twenty-four hours later, hepatic and serum radioactive cholesterol levels were determined. The ED(50 )of inhibitor 1 for prevention of the uptake of labeled cholesterol derived from hydrolysis of labeled cholesteryl oleate was 100 micromoles. The toxicity of inhibitor 1 was investigated in a 30 day feeding trial. Inhibitor 1, 100 micromoles or 200 micromoles per day, was added to chow supplemented with 1% cholesterol and 0.5% cholic acid. Clinical chemistry urinalysis and tissue histopathology were obtained. No toxicity differences were noted between control and inhibitor supplemented groups. CONCLUSIONS: Inhibitors of cholesterol esterase may be useful therapeutics for limiting cholesterol absorption

Sudden natural death in a suicide attempt

In this article, we report an unusual case of sudden death arising from a ruptured basilar artery aneurysm during a suicide attempt. A 72-year-old male was found dead in his home after sustaining superficial flesh gunshot wounds (entrance and exit) involving the forehead. The victim had been depressed for several months and had frank suicide intention. The pertinent autopsy findings revealed a superficial nonpenetrating bullet path of the scalp with no skull fractures or brain injuries. However, brain examination identified subarachnoid hemorrhage and subdural clot about the brainstem and within the posterior fossa linked to a basilar artery aneurysm rupture. The cause and manner of death and contributing factors of the "non-lethal" gunshot wounds are discussed

Factors and outcomes in primary care physician retention in rural areas

Background: This paper examines factors influencing physicians’ decisions to practise in rural communities as well as the results of a programme focused on rural recruitment and retention. Methods: Data from two sources were analysed and discussed: 1) telephone interviews with 20 of 33 (61%) recently located rural physicians regarding practice and community factors influencing their practice decisions and 2) a database of 107 graduates of a rural medical education programme who have been in practice for at least three years to examine specialty choice and practice location(s), including moves from their original practice sites.Results: Most rural physicians in this study decided to practise in rural areas because of family ties. Eighty per cent of the physicians participating in the interviews mentioned no negative personal or family factors related to their community of practice. Outcome data on graduates from the rural medical education programme are encouraging. Over 70% opt for primary care and rural practice. Over 80% have remained in their original rural practice location. Conclusion: Keys to success in rural physician retention seem to include identifying and recruiting medical students of rural origin and focusing on a healthy practice environment. Policy makers need to work with local government, schools and employers to offer programmes that provide information on health careers in rural areas and begin to identify local youth for induction in rural health care. Keywords: retention; rural; primary care; physicians; workforc

The hippocampi of children with chromosome 22q11.2 deletion syndrome have localized anterior alterations that predict severity of anxiety

BACKGROUND: Individuals with 22q11.2 deletion syndrome (22q11.2DS) have an elevated risk for schizophrenia, which increases with history of childhood anxiety. Altered hippocampal morphology is a common neuroanatomical feature of 22q11.2DS and idiopathic schizophrenia. Relating hippocampal structure in children with 22q11.2DS to anxiety and impaired cognitive ability could lead to hippocampus-based characterization of psychosis-proneness in this at-risk population. METHODS: We measured hippocampal volume using a semiautomated approach on MRIs collected from typically developing children and children with 22q11.2DS. We then analyzed hippocampal morphology with Localized Components Analysis. We tested the modulating roles of diagnostic group, hippocampal volume, sex and age on local hippocampal shape components. Lastly, volume and shape components were tested as covariates of IQ and anxiety. RESULTS: We included 48 typically developing children and 69 children with 22q11.2DS in our study. Hippocampal volume was reduced bilaterally in children with 22q11.2DS, and these children showed greater variation in the shape of the anterior hippocampus than typically developing children. Children with 22q11.2DS had greater inward deformation of the anterior hippocampus than typically developing children. Greater inward deformation of the anterior hippocampus was associated with greater severity of anxiety, specifically fear of physical injury, within the 22q11.2DS group. LIMITATIONS: Shape alterations are not specific to hippocampal subfields. CONCLUSION: Alterations in the structure of the anterior hippocampus likely affect function and may impact limbic circuitry. We suggest these alterations potentially contribute to anxiety symptoms in individuals with 22q11.2DS through modulatory pathways. Altered hippocampal morphology may be uniquely linked to anxiety risk factors for schizophrenia, which could be a powerful neuroanatomical marker of schizophrenia risk and hence protection

Identifying Optimal Equivalent Area Changes to Reduce Sonic Boom Loudness

This work explores the design space created from modeling the effect of localized geometric changes on a supersonic aircraft’s near-field pressure signature. These geometric changes are used to alter the aircraft’s near-field pressure signature in a way that reduces its sonic boom loudness at the ground. The aircraft used in this work is the NASA 25D concept and its near-field pressure signature is modeled using two separate methods. The first method uses the PANAIR panel code to obtain a near-field pressure signature for an axisymmetric representation of the 25D. This near-field signature is propagated to the ground using the NASA sBOOM propagation code and the perceived level in decibels is calculated using an in-house loudness code called PyLdB. The second method uses the equivalent area distribution of the 25D which is passed directly to sBOOM and the perceived level is again found using PyLdB. To model the geometric changes, the axisymmetric geometry and the equivalent area distributions are independently modified with a parameterized Gaussian deformation. These methods are fast enough to quickly explore the design space and find the change in loudness for different deformation parameters. This design space exploration is used to study loudness changes for both on-design conditions and the effects of deviations from on-design angle of attack, Mach number, and azimuth angle. A genetic algorithm is used in subsequent studies to explore the effects of different atmospheric conditions. These results can be used to inform higher fidelity CFD studies and structural adaptation design on the aircraft