Creation of ventricular septal defects on the beating heart in a new pig model

Background/ Aims: So far, surgical and interventional therapies for muscular ventricular septal defects ( mVSDs) beyond the moderator band have had their limitations. Thus, alternative therapeutic strategies should be developed. We present a new animal model for the evaluation of such strategies. Methods: In a pig model ( n = 9), anterolateral thoracotomy was performed for exposure of the left ventricle. mVSDs were created under two- and three- dimensional echocardiography with a 7.5- mm sharp punch instrument, which was forwarded via a left ventricular puncture without extracorporeal circulation. Results: Creation of mVSDs was successful in all animals ( n = 9) confirmed by echocardiography, hemodynamic measurements and autopsy. The defects were located in the midmuscular ( n = 4), apical ( n = 1), inlet ( n = 2) and anterior part ( n = 2) of the muscular septum. All animals were hemodynamically stable for further procedures. The diameter and shunt volume of the mVSDs were 4.8 - 7.3 mm ( mean: 5.9 mm) and 12.9 - 41.3% ( mean: 22.1%), respectively. Autopsy confirmed in all animals the creation of a substantial defect. Conclusion: The described new technique for creation of an mVSD on the beating heart in a pig model is suitable for the evaluation of new therapeutic strategies for mVSD closure. Copyright (C) 2008 S. Karger AG, Basel

A parametric study of the acoustic properties of thermal cladding systems

Thermal cladding systems have developed and modernised since the first systems were implemented, and predictions of single figure sound insulation improvement, ΔRW, based on the natural frequency, f0, of the spring-mass covering may no longer be reliable. To identify aspects of the compound acoustic behaviour due to multiple power flow paths of the thermal insulating system, a statistical energy analysis (SEA) based prediction model was developed. A simplified calculation of sound insulation improvement, ΔR, is described, allowing the high frequency (f > f0) behaviour of thermal cladding systems to be predicted. A parametric study in which the impact of different construction materials in the model is discussed; the damping constants, elastic properties of the interlayer and fixings, number of fixings, thickness and material properties (including bending stiffness) of the weatherproof outer layer and the heavyweight wall are assessed. While agreement within 4.0 dB (mean absolute differences) between calculated and measured results for thick render (≥8.0 mm) and curtain wall systems can be obtained at high frequencies (f > f0) using the simplified methodology, this approach was not successful at predicting single figure values. This is because single figure values are weighted towards the low frequencies. Correlation of calculated f0 with measured ΔRW is slightly improved (r.m.s. differences of 2.62 compared with 3.21 using the f0 calculation methodology in EN ISO12354 Annex D) when a modified method to calculate the combined stiffness is used. To improve predictions further, a methodology must be developed to obtain the transfer function, Ytr, used to calculate non-resonant coupling loss factor due to the spring-mass resonance of thermal cladding on the heavyweight wall. The mobility of the connections, Yc, should also be accurately characterised to ensure accurate predictions at high frequencies

Renovation and innovation using thermal insulation lining systems - Acoustic performance

Retrofit and design of thermal cladding systems provide an opportunity to improve the acoustic properties of a building. However, the complexity of the calculation process to predict sound insulation improvement may inhibit rather than encourage novelty and innovation. This paper investigates whether it is realistic to calculate the frequency dependant sound insulation improvement due to modern thermal insulation wall lining systems with just a few input parameters. The calculation procedure is tested using measured results for one external thermal insulation composite system (ETICS) and three curtain wall systems. The accuracy of the procedure is examined using three factors: (1) precision of the measurement, (2) variation of some of the basic parameters of the calculation procedure, and (3) an estimation of the standard error of the calculation. For the ETICS, agreement within <6.0 dB is achieved across much of the frequency range and the trend of the extended dip due to the spring-mass action of the panel is corroborated. The case for using this methodology on curtain wall systems is adequate, however, the trend of calculated results is mostly outside of the 95% confidence limits of the measured results. Possible reasons for this include lack of airtightness of all curtain wall systems and additional transmission due to radiation into and out of the cavity, neither of which are included in the model. The assumption of radiating points or lines, rather than a radiating surface involving the whole panel, gave better agreement at high frequencies for three of the four measured systems (f ≥ 2500 Hz)

Increased Short-Term Variability of the QT Interval in Professional Soccer Players: Possible Implications for Arrhythmia Prediction

BACKGROUND: Sudden cardiac death in competitive athletes is rare but it is significantly more frequent than in the normal population. The exact cause is seldom established and is mostly attributed to ventricular fibrillation. Myocardial hypertrophy and slow heart rate, both characteristic changes in top athletes in response to physical conditioning, could be associated with increased propensity for ventricular arrhythmias. We investigated conventional ECG parameters and temporal short-term beat-to-beat variability of repolarization (STV(QT)), a presumptive novel parameter for arrhythmia prediction, in professional soccer players. METHODS: Five-minute 12-lead electrocardiograms were recorded from professional soccer players (n = 76, all males, age 22.0±0.61 years) and age-matched healthy volunteers who do not participate in competitive sports (n = 76, all males, age 22.0±0.54 years). The ECGs were digitized and evaluated off-line. The temporal instability of beat-to-beat heart rate and repolarization were characterized by the calculation of short-term variability of the RR and QT intervals. RESULTS: Heart rate was significantly lower in professional soccer players at rest (61±1.2 vs. 72±1.5/min in controls). The QT interval was prolonged in players at rest (419±3.1 vs. 390±3.6 in controls, p<0.001). QTc was significantly longer in players compared to controls calculated with Fridericia and Hodges correction formulas. Importantly, STV(QT) was significantly higher in players both at rest and immediately after the game compared to controls (4.8±0.14 and 4.3±0.14 vs. 3.5±0.10 ms, both p<0.001, respectively). CONCLUSIONS: STV(QT) is significantly higher in professional soccer players compared to age-matched controls, however, further studies are needed to relate this finding to increased arrhythmia propensity in this population

A novel, psychophysically motivated transmission approach for haptic data streams in telepresence and teleaction systems

One of the key challenges in telepresence and teleaction systems is the fact that a global control loop is closed over a communication network. The transmission delay of haptic information is extremely critical. Therefore, new data samples from the haptic sensors are typically immediately forwarded to the receiver which leads to a large number of packets being generated when using the Internet as the communication infrastructure. We present a novel approach to reduce the amount of packets and therefore data communicated in a telepresence and teleaction system. Our method uses a passive deadband control which only delivers data packets over the network when the sampled sensor data changes more than a given threshold value. The threshold value is determined by psychophysical experiments. This approach leads to a considerable reduction (up to 90%) of packet rate and data rate without sacrificing fidelity and immersiveness of the system. 1

Towards Deadband Control In Networked Teleoperation Systems

One of the key challenges in current bilateral teleoperation systems is the high data packet rate necessary for the transmission of the sampled command and sensor data. We present a novel, psychophysically motivated approach to reduce the packet rate based on a deadband transmission strategy. Data packets are only sent if the sampled signal changes more than a given threshold value

Network Traffic Reduction In Haptic Telepresence Systems by deadband Control

Current haptic (force feedback) telepresence systems operated over a communication network as, e.g. the Internet, require high packet rates for the transmission of the command and sensor signals. A novel approach to reduce the network tra#c by means of deadband control is proposed. Data packets are only sent if the sampled signal changes more than a given threshold value. Passivity based reconstruction methods are introduced to reconstruct the untransmitted values at the receiver guaranteeing stability of the overall system. Experiments show that a packet rate reduction of up to 87% is achieved without impairing transparency