On the motion of an electron in spatially dependent electromagnetostatic fields

This thesis is concerned with finding exact drift velocity expressions and trajectories for the notion of an electron in spatially dependent magnetic and electromagnetic field configurations. Electron notion in static magnetic fields will be analysed first. The fields will be dependent on x and pointing in the Z direction. Exact drift velocities will be obtained for electron motion in an exponentially varying magnetic field. Such a field is monotonically increasing with x and pointing in the positive Z direction. Drift expressions will also be found for a magnetic field with a power law dependence, which is slightly more complicated than the first case. For x greater than zero the magnetic field nay be either monotonically increasing or decreasing. This is governed by the power law dependence, o, being greater or less than zero. The drift velocity expressions obtained are compared with the Alfven drift velocity results in the limit of an adiabatically affected magnetic field. The exact drift expressions simplify to the perturbation results of Alfven. The trajectories for the motion of an electron in the above mentioned magnetostatic fields will also be found, both for bound and unbound orbits. The notion of an electron in a sinusoidal magnetic field varying with x will be analysed and it will be shown that the exact drift results degenerate to the Alfven drift velocity when the field is adiabatically affected. Trajectories for both bound and unbound orbits will again be considered. All the drift velocity results obtained are in terns of well known functions of mathenatical physics. The integral expressions obtained for the trajectories are found to be incomplete forms of the integrals obtained in the drift velocity expressions. In dealing with electromagnetic phenomena spatially dependent electromagnetic fields will be considered. It will be shown that if the electric scalar potential and the magnetic vector potentials have the same functional dependence, then for bound orbits the electron moves with a generalized electric drift velocity combined with an exact magnetic drift expression. Similar trajectory results exist for unbound orbits. Tractable results. will be shown to exist for field configurations in which the electric scalar potential varies as the square of the magnetic vector potential. Solutions to the electron motion will be shown to vary greatly with a parameter Q which is dependent on the constant ô relating the scalar and vector potentials. It will then be shown how the integrals change when the speed of the electron approaches the speed of light. To illustrate these three results a magnetic field with a simple exponential dependence on x together with the corresponding electric fields will be used. Further generalizations of the work by piecewise smoothing techniques will be indicated. It will also be shown how this work nay be used in upper atmospheric physics, especially in the realm of electron notion in the magnetic tail of the earth. The applicability of the work to problems in laboratory physics will also be discussed, and it will be shown that for special cases the above results nay be used to describe electron motion in the meridian plane of an axially symmetric field.Thesis (MSc) -- University of Adelaide, Mawson Institute for Antarctic Research, 197

Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23

Neutrophil activation and adhesion must be tightly controlled to prevent complications associated with excessive inflammatory responses. The role of the anti-inflammatory peptide chemerin15 (C15) and the receptor ChemR23 in neutrophil physiology is unknown. Here, we report that ChemR23 is expressed in neutrophil granules and rapidly upregulated upon neutrophil activation. C15 inhibits integrin activation and clustering, reducing neutrophil adhesion and chemotaxis in vitro. In the inflamed microvasculature, C15 rapidly modulates neutrophil physiology inducing adherent cell detachment from the inflamed endothelium, while reducing neutrophil recruitment and heart damage in a murine myocardial infarction model. These effects are mediated through ChemR23. We identify the C15/ChemR23 pathway as a new regulator and thus therapeutic target in neutrophil-driven pathologies

Microvesicles and exosomes: new players in metabolic and cardiovascular disease

The past decade has witnessed an exponential increase in the number of publications referring to extracellular vesicles (EVs). For many years considered to be extracellular debris, EVs are now seen as novel mediators of endocrine signalling via cell-to-cell communication. With the capability of transferring proteins and nucleic acids from one cell to another, they have become an attractive focus of research for different pathological settings and are now regarded as both mediators and biomarkers of disease including cardio-metabolic disease. They also offer therapeutic potential as signalling agents capable of targeting tissues or cells with specific peptides or miRNAs. In this review, we focus on the role that microvesicles (MVs) and exosomes, the two most studied classes of EV, have in diabetes, cardiovascular disease, endothelial dysfunction, coagulopathies, and polycystic ovary syndrome. We also provide an overview of current developments in MV/exosome isolation techniques from plasma and other fluids, comparing different available commercial and non-commercial methods. We describe different techniques for their optical/biochemical characterization and quantitation. We also review the signalling pathways that exosomes and MVs activate in target cells and provide some insight into their use as biomarkers or potential therapeutic agents. In summary, we give an updated focus on the role that these exciting novel nanoparticles offer for the endocrine community

The Acute Effect of Magnesium Supplementation on Endothelial Function: A randomized cross-over pilot study

: Magnesium (Mg) deficiency might be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim of this study was to determine the acute effect of an oral Mg supplement as compared to control on endothelial function assessed by flow-mediated dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9 kg/m2 ) completed this randomized cross-over study. Blood pressure (BP) and FMD were measured and blood samples were taken before participants drank 200 mL water, with or without an over the counter Mg supplement (450 mg and 300 mg for men and women). Measurements were repeated at 60 and 120 min. There was a statistically significant two-way interaction between treatment and time on serum Mg (p = 0.037). A difference of −0.085 mm in FMD was observed 60-min post drink in the control group, as compared to baseline FMD, and no difference was observed in the supplement group as compared to baseline. Despite the non-significant interaction between treatment and time on FMD, once adjusted for baseline, the difference seen in the control group and the lack of change in the supplement group at 60 min post-drink suggests that Mg might attenuate the reduction in FMD post-prandiall

Beam deflection lens at terahertz frequencies using a hole lattice metamaterial

The design and simulation of a dielectric lens for beam deflection in the terahertz range is presented. The device consists of a lattice of sub-wavelength holes in a rectangular dielectric slab, and by varying the radii of the holes with respect to position, a gradient index (GRIN) lens can be realised. Beam deflection is achieved by giving the refractive index a ramp-like characteristic. The lens has a flat-profile, and is likely to be more compact than lenses based on geometric optics. A Fresnel lens-like design is used to expand the lens aperture. Additionally, this lens is expected to have lower loss, higher bandwidth, and be less sensitive to polarisation than similar lenses constructed from resonant metamaterials

Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis

Rheumatoid arthritis (RA) is a debilitating disease characterized by persistent accumulation of leukocytes within the articular cavity and synovial tissue. Metabololipidomic profiling of arthritic joints from omega-3 supplemented mice identified elevated levels of specialized proresolving lipid mediators (SPM) including resolvin D1 (RvD1). Profiling of human RA synovial fluid revealed physiological levels of RvD1, which - once applied to human neutrophils - attenuated chemotaxis. These results prompted analyses of the antiarthritic properties of RvD1 in a model of murine inflammatory arthritis. The stable epimer 17R-RvD1 (100 ng/day) significantly attenuated arthritis severity, cachexia, hind-paw edema, and paw leukocyte infiltration and shortened the remission interval. Metabololipidomic profiling in arthritic joints revealed 17R-RvD1 significantly reduced PGE2 biosynthesis, while increasing levels of protective SPM. Molecular analyses indicated that 17R-RvD1 enhanced expression of genes associated with cartilage matrix synthesis, and direct intraarticular treatment induced chondroprotection. Joint protective actions of 17R-RvD1 were abolished in RvD1 receptor-deficient mice termed ALX/fpr2/3-/- . These investigations open new therapeutic avenues for inflammatory joint diseases, providing mechanistic substance for the benefits of omega-3 supplementation in RA

Gratingless integrated tunneling multiplexer for terahertz waves

The arrayed waveguide grating (AWG) is a versatile and scalable passive photonic multiplexer that sees widespread usage. However, the necessity of a waveguide array engenders large device size, and gratings invariably commute finite power into undesired diffraction orders. Here, we demonstrate AWG-like functionality without a grating or waveguide array, yielding benefits to compactness, bandwidth, and efficiency. To this end, we exploit optical tunneling from a dielectric waveguide to an adjacent slab in order to realize a slab-confined frequency-scanning beam, which is manipulated using in-slab beamforming techniques that we have developed in order to separate distinct frequency bands. In this way, we devise an all-intrinsic-silicon integrated 4×1 frequency-division terahertz multiplexer, which is shown to support aggregate data rates up to 48 Gbit/s with an on–off-keying modulation scheme, operating in the vicinity of 350 GHz. Our investigation targets the terahertz range, to provide a critical missing building block for future high-volume wireless communications networks.Daniel Headland, Withawat Withayachumnankul, Masayuki Fujita and Tadao Nagatsum

“An ethnographic seduction”: how qualitative research and Agent-based models can benefit each other

We provide a general analytical framework for empirically informed agent-based simulations. This methodology provides present-day agent-based models with a sound and proper insight as to the behavior of social agents — an insight that statistical data often fall short of providing at least at a micro level and for hidden and sensitive populations. In the other direction, simulations can provide qualitative researchers in sociology, anthropology and other fields with valuable tools for: (a) testing the consistency and pushing the boundaries, of specific theoretical frameworks; (b) replicating and generalizing results; (c) providing a platform for cross-disciplinary validation of results

Terahertz integration platforms using substrateless all-silicon microstructures

The absence of a suitable standard device platform for terahertz waves is currently a major roadblock that is inhibiting the widespread adoption and exploitation of terahertz technology. As a consequence, terahertz-range devices and systems are generally an ad hoc combination of several different heterogeneous technologies and fields of study, which serves perfectly well for a once-off experimental demonstration or proof-of-concept, but is not readily adapted to real-world use case scenarios. In contrast, establishing a common platform would allow us to consolidate our design efforts, define a well-defined scope of specialization for “terahertz engineering,” and to finally move beyond the disconnected efforts that have characterized the past decades. This tutorial will present arguments that nominate substrateless all-silicon microstructures as the most promising candidate due to the low loss of high-resistivity float-zone intrinsic silicon, the compactness of high-contrast dielectric waveguides, the designability of lattice structures, such as effective medium and photonic crystal, physical rigidity, ease and low cost of manufacture using deep-reactive ion etching, and the versatility of the many diverse functional devices and systems that may be integrated. We will present an overview of the historical development of the various constituents of this technology, compare and contrast different approaches in detail, and briefly describe relevant aspects of electromagnetic theory, which we hope will be of assistance.Daniel Headland, Masayuki Fujita, Guillermo Carpintero, Tadao Nagatsuma, and Withawat Withayachumnank

Anthropology and GIS: Temporal and Spatial Distribution of the Philippine Negrito Groups

The Philippine negrito groups comprise a diverse group of populations speaking over 30 different languages, who are spread all over the archipelago, mostly in marginal areas of Luzon Island in the north, the central Visayas islands, and Mindanao in the south. They exhibit physical characteristics that are different from more than 100 Philippine ethnolinguistic groups that are categorized as non-negritos. Given their numbers, it is not surprising that Philippine negritos make up a major category in a number of general ethnographic maps produced since the nineteenth century. Reports from various ethnological surveys during this period, however, have further enriched our understanding regarding the extent and distribution of negrito populations. Using the data contained in these reports, it is possible to plot and create a map showing the historical locations and distribution of negrito groups. Using geographic information systems (GIS), the location and distribution of negrito groups at any given time can be overlaid on historical or current maps. In the present study, a GIS layer was compiled and extracted from the 2000 Philippine Census of population at the village level and overlaid on existing maps of the Philippines. The maps that were generated from this project will complement ongoing anthropological and genetic studies of negrito groups that inhabit different locations within the Philippine archipelago