169,310 research outputs found
Innovation Africa
It is now ten years since the Economist newspaper declared Africa to be “the hopeless continent”. Today, the same magazine offers a different prognosis, building on the World Bank’s prediction of growth rates for sub-Saharan African economies that will be twice those of Europe. This is in the context of a severe and prolonged recession in North America and Europe and a growing realization that the epicentres of development are shifting eastwards, and southwards. Today, I will reflect on what this may mean for some aspects of a small part of innovation. The qualifiers are deliberate; predicting the future in our complex, interconnected world in hubris
Becoming eco-responsible, active citizens through participation in the Eco Ambassadors project - a reflective analysis
This article offers a reflective analysis of the Eco Ambassadors Project as an example of the some of the ways in which learning about environmental issues and active citizenship can be encouraged and enabled through collaboration and negotiated participation. Some policy background to the project is given, followed by a critical consideration of the theoretical framework of situated learning and participation in a community of practice in relation to the project alongside theories of citizenship. Three activities undertaken during the project are highlighted and these are critically examined in relation to the theories under consideration. The paper argues that the theoretical framework of learning by participation can usefully augment and help better explain how learners develop their identities as citizens, and that through participation people can become active members of communities that are environmentally and politically aware
A more general treatment of the philosophy of physics and the existence of universes
Natural philosophy necessarily combines the process of scientific observation
with an abstract (and usually symbolic) framework, which provides a logical
structure to the development of a scientific theory. The metaphysical
underpinning of science includes statements about the process of science
itself, and the nature of both the philosophical and material objects involved
in a scientific investigation. By developing a formalism for an abstract
mathematical description of inherently non-mathematical, physical objects, an
attempt is made to clarify the mechanisms and implications of the philosophical
tool of Ansatz. Outcomes of the analysis include a possible explanation for the
philosophical issue of the 'unreasonable effectiveness' of mathematics as
raised by Wigner, and an investigation into formal definitions of the terms:
principles, evidence, existence and universes that are consistent with the
conventions used in physics. It is found that the formalism places restrictions
on the mathematical properties of objects that represent the tools and terms
mentioned above. This allows one to make testable predictions regarding physics
itself (where the nature of the tools of investigation is now entirely
abstract) just as scientific theories make predictions about the universe at
hand. That is, the mathematical structure of objects defined within the new
formalism has philosophical consequences (via logical arguments) that lead to
profound insights into the nature of the universe, which may serve to guide the
course of future investigations in science and philosophy, and precipitate
inspiring new avenues of research
A Self-Critical Phenomenology of Criticism
Noel Carroll, a central figure in analytic (Anglo-American) philosophy of art, and spouse of renowned dance scholar Sally Banes (who co-authored several of these essays), offers us something remarkable in his new book—namely, a collection of thirty years of his theoretical essays and dance reviews. Carroll
          wrote some of the pieces while he was a graduate student at the University of Illinois, Chicago, and there have been some dramatic changes since then in both the art world and Carroll’s philosophical views. Thus, he modestly characterizes the book as “an archeological artifact” of a “somewhat confessional” variety (p. 267). Inspired by Carroll, I too will adopt an archeological stance, with a promise that the reader’s patience will be repaid with something surprising at the end of the dig
Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation.
Agrin is thought to be the nerve-derived factor that initiates acetylcholine receptor (AChR) clustering at the developing neuromuscularjunction. We have investigated the signaling pathway in mouse C2 myotubes and report that agrin induces a rapid but transient tyrosine phosphorylation of the AChR beta subunit. As the beta-subunit tyrosine phosphorylation occurs before the formation of AChR clusters, it may serve as a precursor step in the clustering mechanism. Consistent with this, we observed that tyrosine phosphorylation of the beta subunit correlated precisely with the presence or absence of clustering under several experimental conditions. Moreover, two tyrosine kinase inhibitors, herbimycin and staurosporine, that blocked beta-subunit phosphorylation also blocked agrin-induced clustering. Surprisingly, the inhibitors also dispersed preformed AChR clusters, suggesting that the tyrosine phosphorylation of other proteins may be required for the maintenance of receptor clusters. These findings indicate that in mammalian muscle, agrin-induced AChR clustering occurs through a mechanism that requires tyrosine phosphorylation and may involve tyrosine phosphorylation of the AChR itself
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