Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines

OBJECTIVE: To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold. METHODS: Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM). RESULTS: Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients. CONCLUSIONS: Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute adverse reactions the starting dose of GSTM should be lowered to 5 mg. Alternatively, patients should be patch-tested before gold therapy; in test-positive cases, 5 mg is recommended as the first dose

Efficacy and Safety of Certolizumab Pegol in a Broad Population of Patients with Active Rheumatoid Arthritis: Week 28 Results From a Phase IIIb Randomized Controlled Study

Pathophysiology and treatment of rheumatic disease

Efficacy and Safety of Certolizumab Pegol in a Broad Population of Patients with Active Rheumatoid Arthritis: Week 28 Results From a Phase IIIb Randomized Controlled Study

Pathophysiology and treatment of rheumatic disease

CERTOLIZUMAB PEGOL IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS ALIGNED WITH NICE GUIDANCE FOR ANTI-TNF THERAPY: POST-HOC ANALYSES OF THE REALISTIC PHASE IIIB RANDOMIZED CONTROLLED STUDY

Pathophysiology and treatment of rheumatic disease

Active transmembrane drug transport in microgravity: a validation study using an ABC transporter model

Schneider Electric (Private entity), granted to Felip Fenollosa - Fundació CIM. Solvo Biotechnology (Private entity), granted to Felip Fenollosa - Fundació CIM. Fundació CIM (Public entity), granted to Felip Fenollosa - Fundació CIM. Institut Municipal d’Investigació Mèdica de Barcelona (IMIM) (Public entity), granted to Rafael de la Torre – IMIM. Lloveras (Private entity), granted to Felip Fenollosa - Fundació CIM. Tecnisample (Private entity), granted to Felip Fenollosa - Fundació CIM. Caixa d’Enginyers (Private entity) granted to Felip Fenollosa - Fundació CIM. Sinerges (Private entity), granted to Felip Fenollosa - Fundació CIM. Col•legi d’Enginyers Tècnics Industrials de Barcelona (Public entity), granted to Felip Fenollosa - Fundació CIM. Interempresas (Private entity), granted to Felip Fenollosa - Fundació CIM. Laboratorio para la Investigación en Espacio y Microgravedad (LEEM) (Public entity), granted to The ABCtr TEAM (SV, EC, AR, AG). Universitat Politècnica de Catalunya (UPC) (Public entity). Grant number: N/A. Granted to: Felip Fenollosa - Fundació CIM. Universitat Autònoma de Barcelona (UAB) (Public entity), granted to Rafael de la Torre – IMIM. European Space Agency via the Education Office and the “Fly your thesis” initiative, Grant number: 9140, granted to The ABCtr TEAM (SV, EC, AR, AG)