Confinement induced instability of thin elastic film

A confined incompressible elastic film does not deform uniformly when subjected to adhesive interfacial stresses but with undulations which have a characteristic wavelength scaling linearly with the thickness of the film. In the classical peel geometry, undulations appear along the contact line below a critical film thickness or below a critical curvature of the plate. Perturbation analysis of the stress equilibrium equations shows that for a critically confined film the total excess energy indeed attains a minima for a finite amplitude of the perturbations which grow with further increase in the confinement.Comment: 11 pages, 6 figure

Allocation in Practice

How do we allocate scarcere sources? How do we fairly allocate costs? These are two pressing challenges facing society today. I discuss two recent projects at NICTA concerning resource and cost allocation. In the first, we have been working with FoodBank Local, a social startup working in collaboration with food bank charities around the world to optimise the logistics of collecting and distributing donated food. Before we can distribute this food, we must decide how to allocate it to different charities and food kitchens. This gives rise to a fair division problem with several new dimensions, rarely considered in the literature. In the second, we have been looking at cost allocation within the distribution network of a large multinational company. This also has several new dimensions rarely considered in the literature.Comment: To appear in Proc. of 37th edition of the German Conference on Artificial Intelligence (KI 2014), Springer LNC

The supernova-regulated ISM. II. The mean magnetic field

The origin and structure of the magnetic fields in the interstellar medium of spiral galaxies is investigated with 3D, non-ideal, compressible MHD simulations, including stratification in the galactic gravity field, differential rotation and radiative cooling. A rectangular domain, 1x1x2 kpc^{3} in size, spans both sides of the galactic mid-plane. Supernova explosions drive transonic turbulence. A seed magnetic field grows exponentially to reach a statistically steady state within 1.6 Gyr. Following Germano (1992) we use volume averaging with a Gaussian kernel to separate magnetic field into a mean field and fluctuations. Such averaging does not satisfy all Reynolds rules, yet allows a formulation of mean-field theory. The mean field thus obtained varies in both space and time. Growth rates differ for the mean-field and fluctuating field and there is clear scale separation between the two elements, whose integral scales are about 0.7 kpc and 0.3 kpc, respectively.Comment: 5 pages, 10 figures, submitted to Monthly Notices Letter

The supernova-regulated ISM. I. The multi-phase structure

We simulate the multi-phase interstellar medium randomly heated and stirred by supernovae, with gravity, differential rotation and other parameters of the solar neighbourhood. Here we describe in detail both numerical and physical aspects of the model, including injection of thermal and kinetic energy by SN explosions, radiative cooling, photoelectric heating and various transport processes. With 3D domain extending 1 kpc^2 horizontally and 2 kpc vertically, the model routinely spans gas number densities 10^-5 - 10^2 cm^-3, temperatures 10-10^8 K, local velocities up to 10^3 km s^-1 (with Mach number up to 25). The thermal structure of the modelled ISM is classified by inspection of the joint probability density of the gas number density and temperature. We confirm that most of the complexity can be captured in terms of just three phases, separated by temperature borderlines at about 10^3 K and 5x10^5 K. The probability distribution of gas density within each phase is approximately lognormal. We clarify the connection between the fractional volume of a phase and its various proxies, and derive an exact relation between the fractional volume and the filling factors defined in terms of the volume and probabilistic averages. These results are discussed in both observational and computational contexts. The correlation scale of the random flows is calculated from the velocity autocorrelation function; it is of order 100 pc and tends to grow with distance from the mid-plane. We use two distinct parameterizations of radiative cooling to show that the multi-phase structure of the gas is robust, as it does not depend significantly on this choice.Comment: 28 pages, 22 figures and 8 table

Specificity in V(D)J recombination: new lessons from biochemistry and genetics

Recent in vitro work on V(D)J recombination has helped to clarify its mechanism. The first stage of the reaction, which can be reproduced with the purified RAG1 and RAG2 proteins, is a site-specific cleavage that generates the same broken DNA species found in vivo. The cleavage reaction is closely related to known types of transpositional recombination, such as that of HIV integrase. All the site specificity of V(D)J recombination, including the 12/23 rule, is determined by the RAG proteins. The later steps largely overlap with the repair of radiation-induced DNA double-strand breaks, as indicated by the identity of several newly characterized factors involved in repair. These developments open the way for a thorough biochemical study of V(D)J recombination

The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans

Cafestol and kahweol–diterpenes present in unfiltered coffee— strongly raise serum VLDL and LDL cholesterol and slightly reduce HDL cholesterol in humans. The mechanism of action is unknown. We determined whether the coffee diterpenes may affect lipoprotein metabolism via effects on lipid transfer proteins and lecithin:cholesterol acyltransferase in a randomized, double-blind cross-over study with 10 healthy male volunteers. Either cafestol (61–64 mg/day) or a mixture of cafestol (60 mg/day) and kahweol (48–54 mg/day) was given for 28 days. Serum activity levels of cholesterylester transfer protein, phospholipid transfer protein and lecithin:cholesterol acyltransferase were measured using exogenous substrate assays. Relative to baseline values, cafestol raised the mean (±S.D.) activity of cholesterylester transfer protein by 18±12% and of phospholipid transfer protein by 21±14% (both P<0.001). Relative to cafestol alone, kahweol had no significant additional effects. Lecithin:cholesterol acyltransferase activity was reduced by 11±12% by cafestol plus kahweol (P=0.02). It is concluded that the effects of coffee diterpenes on plasma lipoproteins may be connected with changes in serum activity levels of lipid transfer proteins

A pearl on SAT solving in Prolog

A succinct SAT solver is presented that exploits the control provided by delay declarations to implement watched literals and unit propagation. Despite its brevity the solver is surprisingly powerful and its elegant use of Prolog constructs is presented as a programming pearl