Pneumatic device of the preload and dynamic loads balancing to reduce the intensity of thermal processes in the metal cutting process

Improved reliability of the technological system "machine-tool-instrument-detail" is an important current task. Backlashes and insufficient stiffness of technological system lead to intensive wear of the cutting tool, increasing the heat in the cutting zone. Due to high temperature in the thin surface layers of the workpiece and tool thermal processes may occur which are similar to release and can cause the structural changes of the material. The current article presents the final design of the device which has been developed to reduce the intensity of thermal processes in metal cutting

Radial-piston pump for drive of test machines

The article reviews the development of radial-piston pump with phase control and alternating-flow mode for seismic-testing platforms and other test machines. The prospects for use of the developed device are proved. It is noted that the method of frequency modulation with the detection of the natural frequencies is easily realized by using the radial-piston pump. The prospects of further research are given proof

Quench propagation and protection analysis of the ATLAS Toroids

The ATLAS superconducting magnet system consists of the Barrel Toroid, two End Cap Toroids and the Central Solenoid. However, the Toroids of eight coils each are magnetically separate systems to the Central Solenoid. The Toroids are electrically connected in series and energized by a single power supply. The quench protection system is based on the use of relatively small external dump resistances in combination with quench-heaters activated after a quench event detection to initiate the internal dump of stored energy in all the coils. A rather strong quench-back effect due to eddy-currents in the coil casings at the transport current decay is beneficial for the quench protection efficiency in the event of heater failures. The quench behaviour of the ATLAS Toroids was computer simulated for normal operation of the quench protection system and its complete non-operation (failure) mode. (3 refs)

Radial-piston pump for drive of test machines

The article reviews the development of radial-piston pump with phase control and alternating-flow mode for seismic-testing platforms and other test machines. The prospects for use of the developed device are proved. It is noted that the method of frequency modulation with the detection of the natural frequencies is easily realized by using the radial-piston pump. The prospects of further research are given proof

Quench propagation and detection in the superconducting bus-bars of the ATLAS magnets

The ATLAS superconducting magnet system comprising Barrel (BT) and End-Cap Toroids (ECT) and also Central Solenoid (CS) will store more than 1.5 GJ of magnetic energy. The magnet system will have many superconducting busbars, a few meters long each, running from the current leads to Central Solenoid and Toroids as well as between the coils of each Toroid. Quench development in the busbars, i.e., the normal zone propagation process along the busbar superconductors, is slow and exhibits very low voltages. Therefore, its timely and appropriate detection represents a real challenge. The temperature evolution in the busbars under quench is of primary importance. Conservative calculations of the temperature were performed for all the magnets. Also, a simple and effective method to detect a normal zone in a busbar is presented. A thin superconducting wire, whose normal resistance can be easily detected, is placed in a good thermal contact to busbar. Thus, the wire can operate as straightforward and low-noise quench-detector. (4 refs)

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation

Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS components to initiate anti-bacterial mechanisms. The Yersinia pestis T3SS is particularly effective and sophisticated in manipulating the production of pro-inflammatory cytokines IL-1beta and IL-18, which are typically processed into their mature forms by active caspase-1 following inflammasome formation. Some effectors, like Y. pestis YopM, may block inflammasome activation. Here we show that YopM prevents Y. pestis induced activation of the Pyrin inflammasome induced by the RhoA-inhibiting effector YopE, which is a GTPase activating protein. YopM blocks YopE-induced Pyrin-mediated caspase-1 dependent IL-1beta/IL-18 production and cell death. We also detected YopM in a complex with Pyrin and kinases RSK1 and PKN1, putative negative regulators of Pyrin. In contrast to wild-type mice, Pyrin deficient mice were also highly susceptible to an attenuated Y. pestis strain lacking YopM, emphasizing the importance of inhibition of Pyrin in vivo. A complex interplay between the Y. pestis T3SS and IL-1beta/IL-18 production is evident, involving at least four inflammasome pathways. The secreted effector YopJ triggers caspase-8- dependent IL-1beta activation, even when YopM is present. Additionally, the presence of the T3SS needle/translocon activates NLRP3 and NLRC4-dependent IL-1beta generation, which is blocked by YopK, but not by YopM. Taken together, the data suggest YopM specificity for obstructing the Pyrin pathway, as the effector does not appear to block Y. pestis-induced NLRP3, NLRC4 or caspase-8 dependent caspase-1 processing. Thus, we identify Y. pestis YopM as a microbial inhibitor of the Pyrin inflammasome. The fact that so many of the Y. pestis T3SS components are participating in regulation of IL-1beta/IL-18 release suggests that these effects are essential for maximal control of innate immunity during plague

A new approach for producing of film structures based on Si1-xGex

In this work, we propose a new, previously unpresented in the literature, approach to the formation of Si1-xGex films. This approach includes electrochemical processes of the formation of porous silicon, electrochemical deposition of low-melting metals and Ge. Post-heat treatment is made possible to synthesize film structures based on Si1-xGex solid solutions. Using this approach an alloy of the composition Si0.4Ge0.6 has been obtained at a lower formation temperature than predicted by the phase diagram for the Si-Ge system