9,769 research outputs found
Surface effects on the statistics of the local density of states in metallic nanoparticles: manifestation on the NMR spectra
In metallic nanoparticles, shifts in the ionization energy of surface atoms
with respect to bulk atoms can lead to surface bands. Within a simple Tight
Binding model we find that the projection of the electronic density of states
on these sites presents two overlapping structures. One of them is
characterized by the level spacing coming from bulk states and the other arises
from the surface states. In very small particles, this contributes to an
over-broadening of the NMR absorption spectra, determined by the Knight shift
distribution of magnetic nuclei. We compare our calculated Knight shifts with
experiments on aluminum nanoparticles, and show that the deviation of the
scaling law as a function of temperature and particle size can be explained in
terms of surface states.Comment: 1 tar.gz fil
Exploring clinical psychologists’ attachment to their own personal therapists: Implications for their clinical practice
Background: Attachment theory has made significant contributions to clinical psychology and there is an interest increasing in attachment-informed approaches to therapy. Attachment research suggests that successful psychotherapy relies on therapists’ attachment security and their ability to reflect on the therapist-client attachment interplay. However, therapists with insecure attachment often struggle with lower reflective function (RF). Personal therapy (PT) can develop RF and attachment awareness in clinical psychologists (CPs). Aim: To study how reflecting about CPs’ relationships with their personal therapist contributes to their awareness and understanding of their own attachment and its implications for their practice. Methods: From a social constructionist approach, 12 CPs were interviewed. Thematic analysis was used to analyse interview transcripts. Results: Thematic analysis resulted in three main themes: constructing and understanding their own attachment; bringing in an emotional dimension into attachment; and the clinical implications of attachment awareness. Conclusion: Through PT, CPs’ increased their awareness about their own attachment. The idea of attachment security was deconstructed, in support of a range of attachment responses that CPs can reflect about when interacting with others. This forged a sense of robustness in the self from where to work relationally with clients, raising clients’ awareness about their relational needs in the TR
320g Ionization-Heat Cryogenic Detector for Dark Matter Search in the EDELWEISS Experiment
The EDELWEISS experiment used in 2001 a 320g heat-and-ionization cryogenic Ge
detector operated in a low-background environment in the Laboratoire Souterrain
de Modane for direct WIMP detection. This detector presents an increase of more
than 4 times the mass of previous detectors. Calibrations of this detector are
used to determine its energy resolution and fiducial volume, and to optimize
the detector design for the 1kg phase of the EDELWEISS-I experiment. Analysis
of the calibrations and characteristics of a first series of 320g-detectors are
presented.Comment: 4 pages, 3 figure
How effective are rapid diagnostic tests for Chagas disease?
© 2021 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Diagnosis of chronic Chagas disease relies on the agreement of two conventional serological tests based on distinct antigens. These require cold to preserve reagents and samples, and equipment and trained personnel to run them. Moreover, results turnaround may be delayed for several weeks risking a loss to follow-up of infected subjects, summoning major disadvantages to access diagnosis (and treatment) in many highly endemic areas. Areas covered: Recent studies have shown the versatility of rapid diagnostic tests for the detection of chronic Trypanosoma cruzi infections in referral centers and in field campaigns, with a performance equivalent to that of conventional tools. Remarkably, RDTs do not require cold storage and provide results within an hour. Additionally, they are easy-to-use and can work with a tiny volume of finger-pricked whole blood. Altogether, major advantages toward generalizing their use as an alternative to conventional tests. Expert opinion: Already in 2021, only a small percentage of T. cruzi-infected people are diagnosed and treated. The unsuitability of currently used diagnostics, and of the recommended algorithm, to the conditions found in many regions do not help to fill this gap. RDTs stand as a promising solution, even though geographical validation should precede their implementation
Higgs boson production via vector-like top-partner decays: diphoton or multilepton plus multijets channels at the LHC
We first build a minimal model of vector-like quarks where the dominant Higgs
boson production process at LHC -- the gluon fusion -- can be significantly
suppressed, being motivated by the recent stringent constraints from the search
for direct Higgs production over a wide Higgs mass range. Within this model,
compatible with the present experimental constraints on direct Higgs searches,
we demonstrate that the Higgs () production via a heavy vector-like
top-partner () decay, , , allows to
discover a Higgs boson at the LHC and measure its mass, through the decay
channels or . We also comment on the recent hint
in LHC data from a possible GeV Higgs scalar, in the presence of
heavy vector-like top quarks.Comment: 14 pages, 8 figure
Biosimilar Pegfilgrastim: Improving Access and Optimising Practice to Supportive Care that Enables Cure
Febrile neutropenia (FN) is a serious complication of chemotherapy, which can cause significant morbidity and mortality, result in dose delays and reductions and, ultimately, reduce cancer survival. Over the past decade, the availability of biosimilar filgrastim (short-acting granulocyte colony-stimulating factor [G-CSF]) has transformed patient access, with clear evidence of clinical benefit at preventing FN at reduced costs. In 2019, seven biosimilar pegfilgrastims (long-acting G-CSFs) were licensed, creating optimal market conditions and choice for prescribers. FN affects up to 117 per 1000 cancer patients, with mortality rates in the range of 2–21%. By reducing FN incidence and improving chemotherapy relative dose intensity (RDI), G-CSF has been associated with a 3.2% absolute survival benefit. Guidelines recommend primary prophylaxis and that filgrastim be administered for 10–14 days, while pegfilgrastim is administered once per cycle. When taken according to the guidelines, pegfilgrastim and filgrastim are equally effective. However, in routine clinical practice, filgrastim is often under-dosed (< 7 days) and has been shown to be inferior to pegfilgrastim at reducing FN incidence, hospitalisations and maintaining RDI. Once-per-cycle administration with pegfilgrastim might also aid patient adherence. The introduction of biosimilar pegfilgrastim should instigate a rethink of neutropenia management. Biosimilar pegfilgrastim
Effects of pre and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4years of age
There are at present very few studies of the effects of polybromodiphenyl ethers (PBDEs), used as flame retardants in consumer products, on neurodevelopment or thyroid hormone levels in humans. The present study aims to examine the association between pre and postnatal PBDE concentrations and neurodevelopment and thyroid hormone levels in children at age 4. years and isolate the effects of PBDEs from those of PCBs, DDT, DDE and HCB.A prospective birth cohort in Menorca (Spain) enrolled 482 pregnant mothers between 1997 and 1998. At 4. years, children were assessed for motor and cognitive function (McCarthy Scales of Children's Abilities), attention-deficit, hyperactivity and impulsivity (ADHD-DSM-IV) and social competence (California Preschool Social Competence Scale). PBDE concentrations were measured in cord blood (N = 88) and in serum of 4. years olds (N = 244). Among all congeners analyzed only PBDE 47 was quantified in a reasonable number of samples (LOQ = 0.002. ng/ml). Exposure to PBDE 47 was analyzed as a dichotomous variable: concentrations above the LOQ (exposed) and concentrations below (referents).Scores for cognitive and motor functions were always lower in children pre and postnatally exposed to PBDE47 than in referents, but none of these associations was statistically significant (β coefficient (95%CI) of the total cognition score: -2.7 (-7.0, 1.6) for postnatal exposure, and -1.4 (-9.2, 6.5) for prenatal exposure). Postnatal exposure to PBDE 47 was statistically significantly related to an increased risk of symptoms on the attention deficit subscale of ADHD symptoms (RR (95%CI) = 1.8 (1.0, 3.2)) but not to hyperactivity symptoms. A statistically significant higher risk of poor social competence symptoms was observed as a consequence of postnatal PBDE 47 exposure (RR (95%CI) = 2.6 (1.2, 5.9)). Adjustment for other organochlorine compounds did not influence the results. Levels of thyroid hormones were not associated to PBDE exposure.This study highlights the importance of assessing the effects of PBDE exposure not just prenatally but also during the early years of life. In the light of current evidence a precautionary approach towards PBDE exposure of both mothers and children seems warranted. © 2010 Elsevier Ltd
Effects of Residue Background Events in Direct Dark Matter Detection Experiments on the Determination of the WIMP Mass
In the earlier work on the development of a model-independent data analysis
method for determining the mass of Weakly Interacting Massive Particles (WIMPs)
by using measured recoil energies from direct Dark Matter detection experiments
directly, it was assumed that the analyzed data sets are background-free, i.e.,
all events are WIMP signals. In this article, as a more realistic study, we
take into account a fraction of possible residue background events, which pass
all discrimination criteria and then mix with other real WIMP-induced events in
our data sets. Our simulations show that, for the determination of the WIMP
mass, the maximal acceptable fraction of residue background events in the
analyzed data sets of O(50) total events is ~20%, for background windows of the
entire experimental possible energy ranges, or in low energy ranges; while, for
background windows in relatively higher energy ranges, this maximal acceptable
fraction of residue background events can not be larger than ~10%. For a WIMP
mass of 100 GeV with 20% background events in the windows of the entire
experimental possible energy ranges, the reconstructed WIMP mass and the
1-sigma statistical uncertainty are ~97 GeV^{+61%}_{-35%} (~94
GeV^{+55%}_{-33%} for background-free data sets).Comment: 27 pages, 22 eps figures; v2: revised version for publication,
references added and update
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