Original Russian Text © I.I. Mokhov, A

We performed analysis of variations in the characteristics of cyclonic activity and cloudiness, including their mutual variations in the atmosphere of the Northern Hemisphere (NH) from the tropical to polar latitudes based from model calculations under the condition of climate changes in comparison with the satellite data and reanalysis data The objective of the joint analysis of variations in the characteristics of cyclonic activity and cloudiness during climate changes is related to the necessity of diagnosis the joint evolution and mutual influence of the general atmospheric circulation and radiationcloudiness processes in the climate system In our analysis, we used the results of numerical simulations of the daily global fields at sealevel pressure (SLP) and cloudiness with the climate general calculation model (CGCM) IPSL-CM4 In the calculation performed with the CMGH IPSK-CM4 model, we specified anthropogenic emissions of greenhouse gases and aerosol into the atmosphere based on the data of observations for the period 1860-2000 and according to the anthropogenic scenario SRES-A2 for 2001-2100. Cyclones and anticyclones were distinguished as regions of low and high pressure, respectively, limited by closed contour lines (isohypses) based on the data of geopotential similarly to [9] (see also We used for comparison the results of the analysis of cyclonic activit

Влияние океанического притока тепла в Баренцево море на региональные изменения ледовитости и статической устойчивости атмосферы

The influence of the oceanic heat inflow into the Barents Sea on the sea ice concentration and atmospheric characteristics, including the atmospheric static stability during winter months, is investigated on the basis of the results of ensemble simulations with the regional climate model HIRHAM/NAOSIM for the Arctic. The static stability of the atmosphere is the important indicator of the spatial and temporal variability of polar mesocyclones in the Arctic region. The results of the HIRHAM/NAOSIM regional climate model ensemble simulations (RCM) for the period from 1979 to 2016 were used for the analysis. The initial and lateral boundary conditions for RCM in the atmosphere were set in accordance with the ERA-Interim reanalysis data. An analysis of 10 ensemble simulations with identical boundary conditions and the same radiation forcing for the Arctic was performed. Various realizations of ensemble simulations with RCM were obtained by changing the initial conditions for integrating the oceanic block of the model. Different realizations of ensemble simulations with RCM are obtained by changing the initial conditions of the model oceanic block integration. The composites method was used for the analysis, i.e. the difference between the mean values for years with the maximum and minimum inflow of oceanic water into the Barents Sea. The statistical significance of the results (at a significance level of p < 0.05) was estimated using Student's t-test. In general, the regional climate model reproduces the seasonal changes in the inflow of the oceanic water and heat into the Barents Sea reasonably well. There is a strong relationship between the changes in the oceanic water and ocean heat inflow, sea ice concentration, and surface air temperature in the Barents Sea. Herewith, the increase in the oceanic water inflow into the Barents Sea in winter leads to a decrease in static stability, which contributes to changes in regional cyclonic activity. The decrease of the static stability is most pronounced in the southern part of the Barents Sea and also to the west of Svalbard.На основе результатов ансамблевых расчётов с использованием региональной климатической модели HIRHAM/NAOSIM для Арктики исследовано влияние притока океанических вод в Баренцево море на концентрацию морских льдов и характеристики атмосферы в зимние месяцы. Показана определяющая роль вариаций притока океанических вод в Баренцево море на режим морских льдов и приповерхностной температуры воздуха, а также статическую устойчивость атмосферы в зимний период

Современные концепции молекулярного патогенеза рака щитовидной железы

Thyroid cancer remains the most common malignancy of the endocrine system worldwide. The indicators of its morbidity and mortality rates have been increasing rapidly over the last decades. Most cases of differentiated thyroid cancer (follicular and papillary histotypes) are clinically manifested by nodular goiter frequently combined with uncertain results of cytological diagnosis (categories III and IV according to the Bethesda (Bethesda System for Reporting Thyroid Cytopathology) classification). All of that makes it difficult to choose a proper tactic for patient treatment. It is known that the development, progression, invasion, and metastasis of cancer cells are regulated by a variety of molecular mechanisms. This review describes several molecular aspects of thyroid nodules oncogenesis, as well as its most promising diagnostic tumor markers. Following molecular pathways are described in particular: gene mutations, protein tumor markers, and epigenetic effects of micro-RNA, histones, as well as DNA methylation. The study of the pathogenesis of this disease has a prognostic value and contributes to the search for effective therapeutic and diagnostic methods and their improvement. That is why we also reviewed modern test panels aimed at preoperative differential diagnosis of thyroid nodules. Summarizing the results of world research on this topic allows us not only to expand the understanding of the fundamental processes of oncogenesis, but also to outline promising areas for future experimental research projects. All of that together will contribute to developing new prognostic, diagnostic and therapeutic technologies, and as a result, will improve the quality of medical care for patients with thyroid cancer.Рак щитовидной железы – распространенное злокачественное новообразование эндокринной системы. В последние десятилетия показатели заболеваемости и смертности вследствие этой патологии стремительно увеличиваются. Большинство случаев дифференцированного рака щитовидной железы (фолликулярного и папиллярного гистотипов) клинически проявляются как узловой зоб. Неопределенность результатов цитологической диагностики (категории III и IV по классификации Bethesda (Bethesda System for Reporting Thyroid Cytopathology)) обусловливает сложности в выборе тактики ведения пациентов. Известно, что развитие, прогрессирование, инвазия и метастазирование раковых клеток регулируются множеством молекулярных механизмов. В данной статье описываются некоторые молекулярные аспекты онкогенеза узловых образований щитовидной железы, а также наиболее перспективные диагностические онкомаркеры. В частности, рассматривается роль генных мутаций, белковых маркеров, эпигенетических воздействий микроРНК, гистонов и метилирования ДНК в патогенезе рака щитовидной железы. Изучение патогенеза этого заболевания имеет прогностическую ценность и способствует поиску эффективных лечебно-диагностических методов и их совершенствованию. Поэтому в исследовании были рассмотрены применяемые в настоящий момент тест-панели, направленные на дооперационную дифференциальную диагностику узловых образований щитовидной железы. Анализ и обобщение результатов исследований по данной теме позволят не только расширить понимание фундаментальных процессов онкогенеза, но и наметить перспективные направления планирования экспериментальных научных работ для разработки новых прогностических, диагностических и терапевтических технологий с целью повышения качества медицинской помощи пациентам с раком щитовидной железы

Original Russian Text © I.I. Mokhov, A

We performed analysis of variations in the characteristics of cyclonic activity and cloudiness, including their mutual variations in the atmosphere of the Northern Hemisphere (NH) from the tropical to polar latitudes based from model calculations under the condition of climate changes in comparison with the satellite data and reanalysis data The objective of the joint analysis of variations in the characteristics of cyclonic activity and cloudiness during climate changes is related to the necessity of diagnosis the joint evolution and mutual influence of the general atmospheric circulation and radiationcloudiness processes in the climate system In our analysis, we used the results of numerical simulations of the daily global fields at sealevel pressure (SLP) and cloudiness with the climate general calculation model (CGCM) IPSL-CM4 In the calculation performed with the CMGH IPSK-CM4 model, we specified anthropogenic emissions of greenhouse gases and aerosol into the atmosphere based on the data of observations for the period 1860-2000 and according to the anthropogenic scenario SRES-A2 for 2001-2100. Cyclones and anticyclones were distinguished as regions of low and high pressure, respectively, limited by closed contour lines (isohypses) based on the data of geopotential similarly to [9] (see also We used for comparison the results of the analysis of cyclonic activit

The influence of ocean heat transport in the Barents Sea on the regional sea ice and the atmospheric static stability

The influence of the oceanic heat inflow into the Barents Sea on the sea ice concentration and atmospheric characteristics, including the atmospheric static stability during winter months, is investigated on the basis of the results of ensemble simulations with the regional climate model HIRHAM/NAOSIM for the Arctic. The static stability of the atmosphere is the important indicator of the spatial and temporal variability of polar mesocyclones in the Arctic region. The results of the HIRHAM/NAOSIM regional climate model ensemble simulations (RCM) for the period from 1979 to 2016 were used for the analysis. The initial and lateral boundary conditions for RCM in the atmosphere were set in accordance with the ERA-Interim reanalysis data. An analysis of 10 ensemble simulations with identical boundary conditions and the same radiation forcing for the Arctic was performed. Various realizations of ensemble simulations with RCM were obtained by changing the initial conditions for integrating the oceanic block of the model. Different realizations of ensemble simulations with RCM are obtained by changing the initial conditions of the model oceanic block integration. The composites method was used for the analysis, i.e. the difference between the mean values for years with the maximum and minimum inflow of oceanic water into the Barents Sea. The statistical significance of the results (at a significance level of p < 0.05) was estimated using Student's t-test. In general, the regional climate model reproduces the seasonal changes in the inflow of the oceanic water and heat into the Barents Sea reasonably well. There is a strong relationship between the changes in the oceanic water and ocean heat inflow, sea ice concentration, and surface air temperature in the Barents Sea. Herewith, the increase in the oceanic water inflow into the Barents Sea in winter leads to a decrease in static stability, which contributes to changes in regional cyclonic activity. The decrease of the static stability is most pronounced in the southern part of the Barents Sea and also to the west of Svalbard

Synthesis and characterization of CdS nanoparticle based multiwall carbon nanotube-maleic anhydride-1-octene nanocomposites

CdS nanoparticles were synthesized by sonication from cadmium chloride and thiourea using a multiwall carbon nanotube (MWCNT)-maleic anhydride (MA)-1-octene system as the matrix. The matrix was obtained by the "grafting from" approach from oxidized carbon nanotubes and maleic anhydride-1-octene. Multiwall carbon nanotubes used for reinforcing the matrix were synthesized by Catalytic Chemical Vapor Deposition using Fe-Co/Al2O3 as the catalyst. The obtained nanostructures were characterized by FTIR, XRD, Raman spectroscopy, TEM, SEM and UV-vis spectroscopy. The average CdS particle diameter was 7.9 nm as confirmed independently by TEM and XRD. UV-vis spectroscopy revealed that the obtained nanostructure is an appropriate base material for making optical devices. The novelty of this work is the use of the MWCNT-MA-1-octene matrix obtained via the "grafting from" approach for the synthesis of uniformly dispersed CdS nanocrystals by ultrasonic cavitation to obtain a polymer nanocomposite. (C) 2015 Elsevier B.V. All rights reserved

Antibiotic therapy for acute respiratory viral infections in children:what do parents know about antibiotics and antibiotic resistance?

One of the causes of antibiotic resistance (AR) is irrational use of antibiotics (ABs) that are commonly administered to patients with acute respiratory viral infections (ARVIs). Rational AB use largely depends on the awareness of people. Objective. To analyze the awareness of people about AR and AB use, as well as to assess the attitude to AB therapy among parents of preschool children. Materials and methods. We conducted anonymous survey among 513 parents of preschool children in Tomsk. Results. Almost two-thirds (61.6%) of respondents admitted that their children received AB during cold/flu/ARVI. The most commonly used ABs were amoxicillin (62.3%), azithromycin (19.7%), and amoxicillin with clavulanic acid (11.1%). The majority of patients administered ABs to their children only after doctor's prescription (80.4%) and adhered to treatment regimen (79.7%). A total of 65.8% respondents stated that doctors had explained why AB therapy was necessary. Nearly two out of three parents (62.4%) believed that ABs may have a negative impact on health. More than half of the respondents were aware of AR. Conclusion. The majority of parents use antibiotics to treat ARVI in their children only with doctor's prescription. However, we observed insufficient awareness about AR, AB use, and possible side effects, which necessitates the development of educational programs for the population