Quark-lepton symmetry and complementarity

We argue that the difference between the observed approximate quark-lepton complementarity and the theoretical prediction based on realistic quark-lepton symmetry within the seesaw mechanism may be adjusted by means of a triplet contribution in the seesaw formula.Comment: 7 pages, RevTex

Leptogenesis and Low-energy Observables

We relate leptogenesis in a class of theories to low-energy experimental observables: quark and lepton masses and mixings. With reasonable assumptions motivated by grand unification, one can show that the CP-asymmetry parameter takes a universal form. Furthermore the dilution mass is related to the light neutrino masses. Overall, these models offer a natural explanation for a lepton asymmetry in the early universe.Comment: 10 pages, revised discussion on light neutrino masse

An adaptive POD approximation method for the control of advection-diffusion equations

We present an algorithm for the approximation of a finite horizon optimal control problem for advection-diffusion equations. The method is based on the coupling between an adaptive POD representation of the solution and a Dynamic Programming approximation scheme for the corresponding evolutive Hamilton-Jacobi equation. We discuss several features regarding the adaptivity of the method, the role of error estimate indicators to choose a time subdivision of the problem and the computation of the basis functions. Some test problems are presented to illustrate the method.Comment: 17 pages, 18 figure

A semi-Lagrangian scheme for the game pp-Laplacian via pp-averaging

We present and analyze an approximation scheme for the two-dimensional game $p$-Laplacian in the framework of viscosity solutions. The approximation is based on a semi-Lagrangian scheme which exploits the idea of $p$-averages. We study the properties of the scheme and prove that it converges, in particular cases, to the viscosity solution of the game $p$-Laplacian. We also present a numerical implementation of the scheme for different values of $p$; the numerical tests show that the scheme is accurate.Comment: 34 pages, 3 figures. To appear on Applied Numerical Mathematic

Neutrino masses and mixings in SO(10)

Assuming a Zee-like matrix for the right-handed neutrino Majorana masses in the see-saw mechanism, one gets maximal mixing for vacuum solar oscillations, a very small value for $U_{e3}$ and an approximate degeneracy for the two lower neutrino masses. The scale of right-handed neutrino Majorana masses is in good agreement with the value expected in a SO(10) model with Pati-Salam SU(4)\ts SU(2)\ts SU(2) intermediate symmetry.Comment: 11 pages, no figures. References adde

Neutrinoless double beta decay in SO(10) inspired seesaw models

By requiring the lower limit for the lightest right-handed neutrino mass, obtained in the baryogenesis from leptogenesis scenario, and a Dirac neutrino mass matrix similar to the up-quark mass matrix we predict small values for the $\nu_e$ mass and for the matrix element $m_{ee}$ responsible of the neutrinoless double beta decay, $m_{\nu_e}$ around $5\cdot10^{-3}$ eV and $m_{ee}$ smaller than $10^{-3}$ eV, respectively. The allowed range for the mass of the heaviest right-handed neutrino is centered around the value of the scale of B - L breaking in the SO(10) gauge theory with Pati-Salam intermediate symmetry.Comment: 9 pages, RevTex4. Revised, title change

Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease

Near-Infrared Spectroscopy (NIR) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom LAIRS spectrometer (IRIS) has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.Publisher PD

Classification and Ranking of Fermi LAT Gamma-ray Sources from the 3FGL Catalog using Machine Learning Techniques

We apply a number of statistical and machine learning techniques to classify and rank gamma-ray sources from the Third Fermi Large Area Telescope (LAT) Source Catalog (3FGL), according to their likelihood of falling into the two major classes of gamma-ray emitters: pulsars (PSR) or Active Galactic Nuclei (AGN). Using 1904 3FGL sources that have been identified/associated with AGN (1738) and PSR (166), we train (using 70% of our sample) and test (using 30%) our algorithms and find that the best overall accuracy (>96%) is obtained with the Random Forest (RF) technique, while using a logistic regression (LR) algorithm results in only marginally lower accuracy. We apply the same techniques on a sub-sample of 142 known gamma-ray pulsars to classify them into two major subcategories: young (YNG) and millisecond pulsars (MSP). Once more, the RF algorithm has the best overall accuracy (~90%), while a boosted LR analysis comes a close second. We apply our two best models (RF and LR) to the entire 3FGL catalog, providing predictions on the likely nature of {\it unassociated} sources, including the likely type of pulsar (YNG or MSP). We also use our predictions to shed light on the possible nature of some gamma-ray sources with known associations (e.g. binaries, SNR/PWN). Finally, we provide a list of plausible X-ray counterparts for some pulsar candidates, obtained using Swift, Chandra, and XMM. The results of our study will be of interest for both in-depth follow-up searches (e.g. pulsar) at various wavelengths, as well as for broader population studies.Comment: Accepted by Ap

MTOR cross-talk in cancer and potential for combination therapy

The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions. mTOR functions through two functionally and structurally distinct multi-component complexes, mTORC1 and mTORC2, which interact with each other and with several elements of other signaling pathways. In the past few years, many new insights into mTOR function and regulation have been gained and extensive genetic and pharmacological studies in mice have enhanced our understanding of how mTOR dysfunction contributes to several diseases, including cancer. Single-agent mTOR targeting, mostly using rapalogs, has so far met limited clinical success; however, due to the extensive cross-talk between mTOR and other pathways, combined approaches are the most promising avenues to improve clinical efficacy of available therapeutics and overcome drug resistance. This review provides a brief and up-to-date narrative on the regulation of mTOR function, the relative contributions of mTORC1 and mTORC2 complexes to cancer development and progression, and prospects for mTOR inhibition as a therapeutic strategy

Seesaw mechanism, baryon asymmetry and neutrinoless double beta decay

A simplified but very instructive analysis of the seesaw mechanism is here performed. Assuming a nearly diagonal Dirac neutrino mass matrix, we study the forms of the Majorana mass matrix of right-handed neutrinos, which reproduce the effective mass matrix of left-handed neutrinos. As a further step, the important effect of a non diagonal Dirac neutrino mass matrix is explored. The corresponding implications for the baryogenesis via leptogenesis and for the neutrinoless double beta decay are reviewed. We propose two distinct models where the baryon asymmetry is enhanced.Comment: 21 pages, RevTex. Revise