15 research outputs found
Modelling of the risk Cryptosporidium parvum infection through drinking tap-water. A pragmatic approach in France
Poster *INRA Biométrie Jouy-en-Josas (FRA) Collation : 1 p. Diffusion du document : INRA Biométrie Jouy-en-Josas (FRA
Disseminated mycobacterial infection in a patient with aids. Endoscopic enteric features
Effect of adding clofazimine to combined clarithromycin-ethambutol therapy for Mycobacterium avium complex septicemia in AIDS patients
Effect of Adding Clofazimine to Combined Clarithromycin-Ethambutol Therapy for Mycobacterium avium Complex Septicemia in AIDS Patients
Actes du 2e séminaire maladies infectieuses émergentes, 7 décembre 2012 - Actualités et propositions = Proceedings of the 2nd seminar on emerging infectious diseases, December 7, 2012 - Current trends and proposals
Soluble FAS Ligand: A Discriminating Feature between Drug-Induced Skin Eruptions and Viral Exanthemas
Infección diseminada por micobacteria atÃpica en un paciente con SIDA: aspecto endoscópico del intestino delgado
Temporary restoration of immune response against Toxoplasma gondii in HIV-infected individuals after HAART, as studied in the hu-PBMC-SCID mouse model
We studied immune reconstitution against the parasite T. gondii in HIV-infected patients treated for 1 years with highly active antiretroviral therapy (HAART). We used SCID mice, humanized with peripheral blood mononuclear cells (PBMC) from patients, which were then infected with T. gondii cysts. Mice humanized with PBMC from patients before the start of HAART were highly susceptible to infection. In contrast, mice humanized with PBMC from patients who had received HAART for 6 months displayed higher survival rates, correlating with lower intracerebral parasite loads. However, this resistance was lost during follow up because mice humanized with PBMC from patients treated with HAART for 12 months survived for no longer than mice that had not been humanized. Specific lymphocyte proliferation assays showed that the increase in proliferative response depended on treatment duration and that HAART induced changes in IFN-γ secretion in the presence of Toxoplasma antigens. Thus, our results indicate partial immune reconstitution against T. gondii in HIV-infected patients following HAART, possibly due to changes in the patterns of specific IFN-γ production and redistribution of functional memory CD4+ cell