Prediction of Modulus of Rupture from Modulus of Elasticity for Some Egyptian Hardwoods

The MOE and MOR of 112 air-dry small, clear specimens (2 x 2 x 30 cm) of six species of hardwoods grown in Egypt were determined. Simple linear regression analysis revealed that MOR is highly correlated with MOE of Eucalyptus camaldulensis, Khaya senegalensis, Tamarix articulata and Casuarina spp. However, the "r" values for Jacaranda ovalifolia and Melia azedarach were not significant. In addition, covariance analysis showed that the six regressions equations have different slopes and Y-intercepts and therefore cannot be grouped. The only grouping was that between the regression lines of the first three species mentiones above.Introducing specific gravity in the regression equation did not result in improving the correlation coefficients, except in the case of Casuarina spp. Using specific gravity alone for predicting the MOR was found to be unreliable due to the relatively low "r" values obtained for the species except in the case of Casuarina spp

Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility

The sequelae of diabetes include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediated renal injury associated with a disruption in mitochondrial metabolic agility, inflammation, and fibrosis. We explored the role of the innate immune complement component C5a, a potent mediator of inflammation, in the pathogenesis of DKD in clinical and experimental diabetes. Marked systemic elevation in C5a activity was demonstrated in patients with diabetes; conventional renoprotective agents did not therapeutically target this elevation. C5a and its receptor (C5aR1) were upregulated early in the disease process and prior to manifest kidney injury in several diverse rodent models of diabetes. Genetic deletion of C5aR1 in mice conferred protection against diabetes-induced renal injury. Transcriptomic profiling of kidney revealed diabetes-induced downregulation of pathways involved in mitochondrial fatty acid metabolism. Interrogation of the lipidomics signature revealed abnormal cardiolipin remodeling in diabetic kidneys, a cardinal sign of disrupted mitochondrial architecture and bioenergetics. In vivo delivery of an orally active inhibitor of C5aR1 (PMX53) reversed the phenotypic changes and normalized the renal mitochondrial fatty acid profile, cardiolipin remodeling, and citric acid cycle intermediates. In vitro exposure of human renal proximal tubular epithelial cells to C5a led to altered mitochondrial respiratory function and reactive oxygen species generation. These experiments provide evidence for a pivotal role of the C5a/C5aR1 axis in propagating renal injury in the development of DKD by disrupting mitochondrial agility, thereby establishing a new immunometabolic signaling pathway in DKD

Market structure, external exposure and industry profitability: evidence from taiwan

This article aims to investigate empirically the influences of concentration, exports, and exchange rate on industry profitability in a small open economy, in Taiwan. Developing a simple theoretical framework and utilizing panel data of four-digit manufacturing industries over the period 1986-96 to test our findings indicate that concentration has a positive impact on profit margin, while the impacts of export intensity and external exposure are significantly negative. This result indicates that export-intensive industries tend to have a lower profitability in Taiwan, because export firms act as price takers in international markets. Moreover, the exchange rate is found to have a relatively strong and significant effect on industry profitability, whereby the devaluation of the New Taiwan Dollar hurts more those industries with a higher share of imported inputs during the sample period.concentration, export, exchange rate, industry profitability,