17 research outputs found
Developmental effects on sleepâwake patterns in infants receiving a cowâs milk-based infant formula with an added prebiotic blend: A Randomized Controlled Trial
Background
Few studies have evaluated nutritive effects of prebiotics on infant behavior state, physiology, or metabolic status.
Methods
In this double-blind randomized study, infants (nâ=â161) received cowâs milk-based infant formula (Control) or similar formula with an added prebiotic blend (polydextrose and galactooligosaccharides [PDX/GOS]) from 14â35 to 112 days of age. Infant wake behavior (crying/fussing, awake/content) and 24-h sleepâwake actograms were analyzed (Baseline, Days 70 and 112). Salivary cortisol was immunoassayed (Days 70 and 112). In a subset, exploratory stool 16S ribosomal RNA-sequencing was analyzed (Baseline, Day 112).
Results
One hundred and thirty-one infants completed the study. Average duration of crying/fussing episodes was similar at Baseline, significantly shorter for PDX/GOS vs. Control at Day 70, and the trajectory continued at Day 112. Latency to first and second nap was significantly longer for PDX/GOS vs. Control at Day 112. Cortisol awakening response was demonstrated at Days 70 and 112. Significant stool microbiome beta-diversity and individual taxa abundance differences were observed in the PDX/GOS group.
Conclusions
Results indicate faster consolidation of daytime waking state in infants receiving prebiotics and support home-based actigraphy to assess early sleepâwake patterns. A prebiotic effect on wake organization is consistent with influence on the gutâbrain axis and warrants further investigation.
Impact
Few studies have evaluated nutritive effects of prebiotics on infant behavior state, cortisol awakening response, sleepâwake entrainment, and gut microbiome.
Faster consolidation of daytime waking state was demonstrated in infants receiving a prebiotic blend in infant formula through ~4 months of age.
Shorter episodes of crying were demonstrated at ~2 months of age (time point corresponding to age/developmental range associated with peak crying) in infants receiving formula with added prebiotics.
Results support home-based actigraphy as a suitable method to assess early sleepâwake patterns.
Prebiotic effect on wake organization is consistent with influence on the gutâbrain axis and warrants further investigation
Associations between infant temperament, maternal stress, and infantsâ sleep across the first year of life
Effects of temperament and maternal stress on infant sleep behaviors were explored longitudinally. Negative temperament was associated with sleep problems, and with longer sleep latency and night wakefulness, whereas maternal stress was associated with day sleep duration, suggesting infant and maternal characteristics affect sleep differentially