A dc to dc converter

The object of the invention is to provide an improved converter for converting one direct current voltage to another. A plurality of phased square wave voltages are provided from a ring counter through amplifiers to a like plurality of output transformers. Each of these transformers has two windings, and S(1) winding and an S(2) winding. The S(1) windings are connected in series, then the S(2) windings are connected in series, and finally, the two sets of windings are connected in series. One of six SCRs is connected between each two series connected windings to a positive output terminal and one of diodes is connected between each set of two windings of a zero output terminal. By virtue of this configuration, a quite high average direct current voltage is obtained, which varies between full voltage and two-thirds full voltage rather than from full voltage to zero. Further, its variation, ripple frequency, is reduced to one-sixth of that present in a single phase system. Application to raising battery voltage for an ion propulsion system is mentioned

High-z radio starbursts host obscured X-ray AGN

We use Virtual Observatory methods to investigate the association between radio and X-ray emission at high redshifts. Fifty-five of the 92 HDF(N) sources resolved by combining MERLIN+VLA data were detected by Chandra, of which 18 are hard enough and bright enough to be obscured AGN. The high-z population of microJy radio sources is dominated by starbursts an order of magnitude more active and more extended than any found at z<1 and at least a quarter of these simultaneously host highly X-ray-luminous obscured AGN.Comment: 4 pages, 2 figures, To appear in the proceedings of 'At the Edge of the Universe' (9-13 October 2006, Sintra, Portugal

An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning

From experiments by Foe and von Dassow (Foe, V.E., and G. von Dassow. 2008. J. Cell Biol. 183:457–470) and others, we infer a molecular mechanism for positioning the cleavage furrow during cytokinesis. Computer simulations reveal how this mechanism depends on quantitative motor-behavior details and explore how robustly this mechanism succeeds across a range of cell sizes

Previously Unidentified Changes in Renal Cell Carcinoma Gene Expression Identified by Parametric Analysis of Microarray Data

BACKGROUND. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number of genome-wide expression profiling studies have been performed. Surprisingly, there is very poor agreement among these studies as to which genes are differentially regulated. To better understand this lack of agreement we profiled renal cell tumor gene expression using genome-wide microarrays (45,000 probe sets) and compare our analysis to previous microarray studies. METHODS. We hybridized total RNA isolated from renal cell tumors and adjacent normal tissue to Affymetrix U133A and U133B arrays. We removed samples with technical defects and removed probesets that failed to exhibit sequence-specific hybridization in any of the samples. We detected differential gene expression in the resulting dataset with parametric methods and identified keywords that are overrepresented in the differentially expressed genes with the Fisher-exact test. RESULTS. We identify 1,234 genes that are more than three-fold changed in renal tumors by t-test, 800 of which have not been previously reported to be altered in renal cell tumors. Of the only 37 genes that have been identified as being differentially expressed in three or more of five previous microarray studies of renal tumor gene expression, our analysis finds 33 of these genes (89%). A key to the sensitivity and power of our analysis is filtering out defective samples and genes that are not reliably detected. CONCLUSIONS. The widespread use of sample-wise voting schemes for detecting differential expression that do not control for false positives likely account for the poor overlap among previous studies. Among the many genes we identified using parametric methods that were not previously reported as being differentially expressed in renal cell tumors are several oncogenes and tumor suppressor genes that likely play important roles in renal cell carcinogenesis. This highlights the need for rigorous statistical approaches in microarray studies.National Institutes of Healt

Child Weight and Feeding Patterns in an Old Order Mennonite Community

Feeding practices in some religious communities may decrease childhood obesity. However, there is limited research in these communities to assess maternal perceptions of their children’s weight and feeding patterns. The purpose of this study was to ascertain Old Order Mennonite mothers’ perceptions of their children’s body weight and to examine feeding patterns for their children. Sample: Participants for this descriptive, correlational study were recruited from an Old Order Mennonite community in south central Kentucky. Sampling was achieved using a snowball sampling strategy and the use of a community insider. Methods: Body Mass Index was measured for mothers and child participants, and mothers completed four questionnaires. Fourteen families with 65 children participated. Findings: Fifteen children (23.1%) had BMIs \u3e 85%, and weight was underestimated in 24.6% of children. Breastfeeding was common (98.5%), with a mean age for cessation of 17.3 months. Mean age for introduction of solid foods was eight months. Results from the CFQ demonstrated mothers were neutral about obesity risk in their child (X=3.05). Mothers reported concerns about high sugar foods, limiting access to unhealthy foods, and children eating all food served at meals. Maternal health literacy scores (X=33.98) were comparable to scores found in other studies. A lower PSOC score (X= 23.36) was found. Conclusions: Further study needs to be conducted in this community to ascertain specific feeding habits that may account for increased BMIs

Bound states of magnons in the S=1/2 quantum spin ladder

We study the excitation spectrum of the two-leg antiferromagnetic S=1/2 Heisenberg ladder. Our approach is based on the description of the excitations as triplets above a strong-coupling singlet ground state. The quasiparticle spectrum is calculated by treating the excitations as a dilute Bose gas with infinite on-site repulsion. We find singlet (S=0) and triplet (S=1) two-particle bound states of the elementary triplets. We argue that bound states generally exist in any dimerized quantum spin model.Comment: 4 REVTeX pages, 4 Postscript figure