211 research outputs found
Solitary colonic metastasis from renal cell carcinoma presenting as a surgical emergency nine years post-nephrectomy
Late colonic metastasis following curative surgery for renal cell carcinoma has rarely been described. We present the first reported case of solitary colonic renal cell carcinoma metastasis presenting as an intra-abdominal bleed, nine years post-nephrectomy
An integrated software system for geometric correction of LANDSAT MSS imagery
A system for geometrically correcting LANDSAT MSS imagery includes all phases of processing, from receiving a raw computer compatible tape (CCT) to the generation of a corrected CCT (or UTM mosaic). The system comprises modules for: (1) control of the processing flow; (2) calculation of satellite ephemeris and attitude parameters, (3) generation of uncorrected files from raw CCT data; (4) creation, management and maintenance of a ground control point library; (5) determination of the image correction equations, using attitude and ephemeris parameters and existing ground control points; (6) generation of corrected LANDSAT file, using the equations determined beforehand; (7) union of LANDSAT scenes to produce and UTM mosaic; and (8) generation of output tape, in super-structure format
Improving Navy MPTE Studies with Model-Driven Big Data
The goal of this research was to improve upon the ability of OPNAV N1 analysts to quickly and efficiently obtain experiment-based information from their computational models. The enhanced information will enable N1’s analysts to better support Navy leadership in resource and policy decisions that shape the future Navy and help it retain and develop its most talented Sailors. This project built on previous collaborations with N1 using data farming to enhance the information gleaned from their Navy talent management models, such as the Officer Strategic Analysis Model (OSAM) model, the Production Resource Optimization (PRO) model, and the Navy Total Force Strength Model (NTFSM). During this research period, (1) Ensign William Desousa (2015) investigated the behavior of economic inputs in NTFSM; (2) Lieutenant Peter Bazalaki (2016) used the new data farming capabilities we developed in OSAM to investigate Surface Warfare Officer (SWO) inventory across a breadth of possibilities; and (3) Lieutenant Allison Hogarth (2016) built, tested, and demonstrated a user interface in Excel that enables users of the PRO model to automatically execute a sophisticated design of experiments—the tool that enables this new capability is known as Production Resource Optimization Model With Experimental Design (PROMWED). In addition to working with the student-officers, the faculty supporting this project performed an empirical study of statistical software packages that may provide better understanding of the high-dimensional behavior of manpower models in the future (Erickson, Ankenman, & Sanchez 2016).Naval Research ProgramPrepared for Topic Sponsor: OPNAV N1; Research POC Name: Mr. Ian AndersoNPS-N16-N154-
Scanning Quantum Decoherence Microscopy
The use of qubits as sensitive magnetometers has been studied theoretically
and recent demonstrated experimentally. In this paper we propose a
generalisation of this concept, where a scanning two-state quantum system is
used to probe the subtle effects of decoherence (as well as its surrounding
electromagnetic environment). Mapping both the Hamiltonian and decoherence
properties of a qubit simultaneously, provides a unique image of the magnetic
(or electric) field properties at the nanoscale. The resulting images are
sensitive to the temporal as well as spatial variation in the fields created by
the sample. As an example we theoretically study two applications of this
technology; one from condensed matter physics, the other biophysics. The
individual components required to realise the simplest version of this device
(characterisation and measurement of qubits, nanoscale positioning) have
already been demonstrated experimentally.Comment: 11 pages, 5 low quality (but arXiv friendly) image
Uma abordagem fuzzy para a avaliação técnico-econômica de redes de acesso
The rising of new technologies and services imposes significant changes to the traditional telecommunications system. The diversity of system evolution settings makes the planning stage an increasingly desirable procedure, mainly in a competitive environment. The use of comprehensive and flexible methodologies that can support the decision process, based in optimization mathematical models, seems to be indispensable. This paper proposes a mixed-integer linear programming model devoted to help the strategic planning of the telecommunication systems, and in the special of the access network. Major components of costs and revenues are identified. The model intends to determine the network configuration (services, technologies, etc.) which maximizes the expected revenue. In order to perform some techno-economical risk analyses in situations with lack of precision in the demand data, fuzzy sets concepts are adopted. Results of computational experiments are presented and discussed.O surgimento de novas tecnologias e serviços vem impondo mudanças substanciais ao tradicional sistema de telecomunicações. Múltiplas possibilidades de evolução do sistema fazem da etapa de planejamento um procedimento não só desejável como necessário, principalmente num ambiente de competitividade. A utilização de metodologias abrangentes e flexÃveis que possam auxiliar no processo de decisão, fundadas em modelos de otimização, parece um caminho inevitável. Este artigo propõe um modelo de programação linear inteiro misto para ajudar no planejamento estratégico de sistemas de telecomunicações, e em particular da rede de acesso. Os principais componentes de custo e receita são identificados e o modelo é desenvolvido para determinar a configuração da rede (serviços, tecnologias, etc) que maximize a receita esperada pelo operador do sistema. O conceito de números fuzzy é adotado para avaliar o risco técnico-econômico em situações de imprecisão nos dados de demanda. Resultados de experimentos computacionais são apresentados e discutidos.22624
Quality of antimalarials at the epicenter of antimalarial drug resistance: results from an overt and mystery client survey in Cambodia.
Widespread availability of monotherapies and falsified antimalarials is thought to have contributed to the historical development of multidrug-resistant malaria in Cambodia. This study aimed to document the quality of artemisinin-containing antimalarials (ACAs) and to compare two methods of collecting antimalarials from drug outlets: through open surveyors and mystery clients (MCs). Few oral artemisinin-based monotherapies and no suspected falsified medicines were found. All 291 samples contained the stated active pharmaceutical ingredient (API) of which 69% were considered good quality by chemical analysis. Overall, medicine quality did not differ by collection method, although open surveyors were less likely to obtain oral artemisinin-based monotherapies than MCs. The results are an encouraging indication of the positive impact of the country's efforts to tackle falsified antimalarials and artemisinin-based monotherapies. However, poor-quality medicines remain an ongoing challenge that demands sustained political will and investment of human and financial resources
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins
Neurodegenerative diseases are an enormous public health problem, affecting tens of millions of people worldwide. Nearly all of these diseases are characterized by oligomerization and fibrillization of neuronal proteins, and there is great interest in therapeutic targeting of these aggregates. Here, we show that soluble aggregates of α-synuclein and tau bind to plate-immobilized PrP in vitro and on mouse cortical neurons, and that this binding requires at least one of the same N-terminal sites at which soluble Aβ aggregates bind. Moreover, soluble aggregates of tau, α-synuclein and Aβ cause both functional (impairment of LTP) and structural (neuritic dystrophy) compromise and these deficits are absent when PrP is ablated, knocked-down, or when neurons are pre-treated with anti-PrP blocking antibodies. Using an all-human experimental paradigm involving: (1) isogenic iPSC-derived neurons expressing or lacking PRNP, and (2) aqueous extracts from brains of individuals who died with Alzheimer's disease, dementia with Lewy bodies, and Pick's disease, we demonstrate that Aβ, α-synuclein and tau are toxic to neurons in a manner that requires PrPC. These results indicate that PrP is likely to play an important role in a variety of late-life neurodegenerative diseases and that therapeutic targeting of PrP, rather than individual disease proteins, may have more benefit for conditions which involve the aggregation of more than one protein
Renormalized Path Integral for the Two-Dimensional Delta-Function Interaction
A path-integral approach for delta-function potentials is presented.
Particular attention is paid to the two-dimensional case, which illustrates the
realization of a quantum anomaly for a scale invariant problem in quantum
mechanics. Our treatment is based on an infinite summation of perturbation
theory that captures the nonperturbative nature of the delta-function bound
state. The well-known singular character of the two-dimensional delta-function
potential is dealt with by considering the renormalized path integral resulting
from a variety of schemes: dimensional, momentum-cutoff, and real-space
regularization. Moreover, compatibility of the bound-state and scattering
sectors is shown.Comment: 26 pages. The paper was significantly expanded and numerous equations
were added for the sake of clarity; the main results and conclusions are
unchange
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