Density, Velocity, and Magnetic Field Structure in Turbulent Molecular Cloud Models

We use 3D numerical MHD simulations to follow the evolution of cold, turbulent, gaseous systems with parameters representing GMC conditions. We study three cloud simulations with varying mean magnetic fields, but identical initial velocity fields. We show that turbulent energy is reduced by a factor two after 0.4-0.8 flow crossing times (2-4 Myr), and that the magnetically supercritical cloud models collapse after ~6 Myr, while the subcritical cloud does not collapse. We compare density, velocity, and magnetic field structure in three sets of snapshots with matched Mach numbers. The volume and column densities are both log-normally distributed, with mean volume density a factor 3-6 times the unperturbed value, but mean column density only a factor 1.1-1.4 times the unperturbed value. We use a binning algorithm to investigate the dependence of kinetic quantities on spatial scale for regions of column density contrast (ROCs). The average velocity dispersion for the ROCs is only weakly correlated with scale, similar to the mean size-linewidth relation for clumps within GMCs. ROCs are often superpositions of spatially unconnected regions that cannot easily be separated using velocity information; the same difficulty may affect observed GMC clumps. We analyze magnetic field structure, and show that in the high density regime, total magnetic field strengths increase with density with logarithmic slope 1/3 -2/3. Mean line-of-sight magnetic field strengths vary widely across a projected cloud, and do not correlate with column density. We compute simulated interstellar polarization maps at varying orientations, and determine that the Chandrasekhar-Fermi formula multiplied by a factor ~0.5 yields a good estimate of the plane-of sky magnetic field strength provided the dispersion in polarization angles is < 25 degrees.Comment: 56 pages, 25 figures; Ap.J., accepte

Analysis of Clumps in Molecular Cloud Models: Mass Spectrum, Shapes, Alignment and Rotation

Observations reveal concentrations of molecular line emission on the sky, called ``clumps,'' in dense, star-forming molecular clouds. These clumps are believed to be the eventual sites of star formation. We study the three-dimensional analogs of clumps using a set of self-consistent, time-dependent numerical models of molecular clouds. The models follow the decay of initially supersonic turbulence in an isothermal, self-gravitating, magnetized fluid. We find the following. (1) Clumps are intrinsically triaxial. This explains the observed deficit of clumps with a projected axis ratio near unity, and the apparent prolateness of clumps. (2) Simulated clump axes are not strongly aligned with the mean magnetic field within clumps, nor with the large-scale mean fields. This is in agreement with observations. (3) The clump mass spectrum has a high-mass slope that is consistent with the Salpeter value. There is a low-mass break in the slope at \sim 0.5 \msun, although this may depend on model parameters including numerical resolution. (4) The typical specific spin angular momentum of clumps is $4 \times 10^{22} {\rm cm^2 s^{-1}}$. This is larger than the median specific angular momentum of binary stars. Scaling arguments suggest that higher resolution simulations may soon be able to resolve the scales at which the angular momentum of binary stars is determined.Comment: 14 pages, 13 figures, to appear in 2003 July 20 Ap

Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses

With increasing age, the ability to produce protective antibodies in response to immunization declines, leading to a reduced efficacy of vaccination in the elderly. To examine the effect of age on the cognate function of CD4 T cells, we have used a novel adoptive transfer model that allows us to compare identical numbers of antigen-specific naive T cells from young and aged TCR transgenic (Tg) donors. Upon transfer of aged donor CD4 T cells to young hosts, there was significantly reduced expansion and germinal center (GC) differentiation of the antigen-specific B cell population after immunization. This reduced cognate helper function was seen at all time points and over a wide range of donor cell numbers. In hosts receiving aged CD4 cells, there were also dramatically lower levels of antigen-specific IgG. These age-related defects were not due to defects in migration of the aged CD4 T cells, but may be attributable to reduced CD154 (CD40L) expression. Furthermore, we found that there was no difference in B cell expansion and differentiation or in IgG production when young CD4 T cells were transferred to young or aged hosts. Our results show that, in this model, age-related reductions in the cognate helper function of CD4 T cells contribute significantly to defects in humoral responses observed in aged individuals

Hyper- and suspended-accretion states of rotating black holes and the durations of gamma-ray bursts

We analyze the temporal evolution of accretion onto rotating black holes subject to large-scale magnetic torques. Wind torques alone drive a disk towards collapse in a finite time $\sim t_{ff} E_k/E_B$, where $t_{ff}$ is the initial free-fall time and $E_k/E_B$ is the ratio of kinetic-to-poloidal magnetic energy. Additional spin-up torques from a rapidly rotating black hole can arrest the disk's inflow. We associate short/long gamma-ray bursts with hyperaccretion/suspended-accretion onto slowly/rapidly spinning black holes. This model predicts afterglow emission from short bursts, and may be tested by HETE-II.Comment: accepted for publication in the ApJ

100 years of chemistry at Rhodes University

The history of Grahamstown is well documented and two books deal with the history of Rhodes University.1,2 Although the Chemistry Department was one of the founding departments, coverage in the official histories is minimal and sometimes inaccurate or misleading. The Rhodes University Centenary is an appropriate time to look back on some of the achievements of the department and some of its graduates over the past 100 years

Enzymatic synthesis of benzylisoquinoline alkaloids using a parallel cascade strategy and tyrosinase variants

Benzylisoquinoline alkaloid derived pharmaceuticals are widely applied in modern medicines. Recent studies on the microbial production of benzylisoquinolines have highlighted key biological syntheses towards these natural products. Routes to non-natural benzylisoquinolines have been less explored, particularly halogenated compounds which are more challenging. Here, we show the use of a tyrosinase, tyrosine decarboxylase, transaminase, and norcoclaurine synthase which are combined in a parallel cascade design, in order to generate halogenated benzylisoquinoline alkaloids in high enantiomeric excess. Notably, mutagenesis studies are applied to generate tyrosinase mutants, which enhance the acceptance of halogenated tyrosines for use in the biocatalytic cascades developed

Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

Using a T cell receptor transgenic (TCR Tg) mouse model, we have shown that TCR Tg CD4 cells from aged mice retain a naive phenotype, but exhibit reduced proliferation and IL-2 production in response to the antigen compared with cells from young mice. We hypothesize that age-related decreases in T cell function may be partly related to the age of the T cells. Because thymic output is decreased with age, peripheral T cells in older individuals are likely to be older than those in younger individuals. To investigate this possibility, we have manipulated the age of CD4 T cells in the periphery of young and aged mice. The production of new T cells was induced by depleting peripheral CD4 T cells or by creating bone marrow chimeras. In both young and aged individuals where we induced the production of new T cells, these newly generated cells exhibited robust responses to antigen ex vivo and in vivo, exhibiting good expansion, IL-2 production, and cognate helper function. Our results suggest that age-related defects in response to antigenic stimulation, in part, are caused by the age of the CD4 T cells

Self-Similar Magnetocentrifugal Disk Winds with Cylindrical Asymptotics

We construct a two-parameter family of models for self-collimated, radially self-similar magnetized outflows from accretion disks. A flow at zero initial poloidal speed leaves the surface of a rotating disk and is accelerated and redirected toward the pole by helical magnetic fields threading the disk. At large distances from the disk, the flow streamlines asymptote to wrap around the surfaces of nested cylinders. In constrast to previous disk wind modeling, we have explicitly implemented the cylindrical asymptotic boundary condition to examine the consequences for flow dynamics. The solutions are characterized by the logarithmic gradient of the magnetic field strength and the ratios between the footpoint radius R_0 and asymptotic radius R_1 of streamlines; the Alfven radius must be found as an eigenvalue. Cylindrical solutions require the magnetic field to drop less steeply than 1/R. We find that the asymptotic poloidal speed on any streamline is typically just a few tenths of the Kepler speed at the corresponding disk footpoint. The asymptotic toroidal Alfven speed is, however, a few times the footpoint Kepler speed. We discuss the implications of the models for interpretations of observed optical jets and molecular outflows from young stellar systems. We suggest that the difficulty of achieving strong collimation in vector velocity simultaneously with a final speed comparable to the disk rotation rate argues against isolated jets and in favor of models with broader winds.Comment: 39 pages, Latex (uses AAS Latex macros), 6 eps figures, postscript preprint with embedded figures available from http://www.astro.umd.edu/~ostriker/professional/publications.html , to appear in ApJ 9/1/9

Day of Archaeology 2011–2017: Global Community, Public Engagement, and Digital Practice.

The Day of Archaeology (http://www.dayofarchaeology.com) was a volunteer-led international archaeological blogging event that ran from 2011 to 2017. The project asked people who define themselves as archaeologists to submit one or more blog posts about their working day on a chosen day in June or July. This article explores the history of the Day of Archaeology project and the practicalities of running a large-scale collaborative blogging project, before examining some of the topics covered in the posts. An assessment of the impact of the project follows. Overall, we hope in this work to answer some of the basic questions regarding this type of collaborative, online, global engagement – what we did, who we reached, what they talked about – and also to provide some insights for any other similar initiatives that may follow us in the future