Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women

PURPOSE: To compare the effects of a high-calcium vitamin D-fortified milk with added FOS-inulin versus regular milk on serum parathyroid hormone, and bone turnover markers in premenopausal (Pre-M) and postmenopausal (PM) women over 12 weeks. METHODS: Premenopausal women (n = 136, mean age 41 (±5) years) and postmenopausal women [n = 121, mean age 59 (±4) years] were recruited, and each age group randomised into two groups to take two glasses per day of control = regular milk (500 mg calcium per day) or intervention (Int) = fortified milk (1000 mg calcium for pre-M women and 1200 mg calcium for PM women, 96 mg magnesium, 2.4 mg zinc, 15 µg vitamin D, 4 g FOS-inulin per day). At baseline, week 4 and week 12 serum minerals and bone biochemical markers were measured and bone density was measured at baseline. RESULTS: Mean 25-hydroxyvitamin D [25(OH) vitamin D3] levels among groups were between 49 and 65 nmol/L at baseline, and over the 12 weeks of supplementation, the fortified milk improved vitamin D status in both Int groups. CTx-1 and PINP reduced significantly in both Pre-M and PM groups over the 12 weeks, with the changes in CTx-1 being significantly different (P < 0.035) between PM control and PM Int groups at week 12. Parathyroid hormone levels were significantly reduced in all groups over time, except for control PM group where levels increased at 12 weeks. CONCLUSION: The overall pattern of responses indicates that while both regular milk and fortified milk reduce bone resorption in young and older women, fortified milk is measurably more effective

Intégrer la formation, la pratique et la réflexion dans un nouveau modèle d’évaluation de la compétence des diplômés en médecine au Canada : un document conceptuel à l’intention du Conseil médical du Canada

In 2020 the Medical Council of Canada created a task force to make recommendations on the modernization of its practices for granting licensure to medical trainees. This task force solicited papers on this topic from subject matter experts. As outlined within this Concept Paper, our proposal would shift licensure away from the traditional focus on high-stakes summative exams in a way that integrates training, clinical practice, and reflection. Specifically, we propose a model of graduated licensure that would have three stages including: a trainee license for trainees that have demonstrated adequate medical knowledge to begin training as a closely supervised resident, a transition to practice license for trainees that have compiled a reflective educational portfolio demonstrating the clinical competence required to begin independent practice with limitations and support, and a fully independent license for unsupervised practice for attendings that have demonstrated competence through a reflective portfolio of clinical analytics. This proposal was reviewed by a diverse group of 30 trainees, practitioners, and administrators in medical education. Their feedback was analyzed and summarized to provide an overview of the likely reception that this proposal would receive from the medical education community.En 2020, le Conseil médical du Canada a créé un groupe de travail chargé de formuler des recommandations sur la modernisation de ses pratiques d’octroi du titre de licencié aux stagiaires en médecine. À cette fin, le groupe de travail a sollicité la contribution d’experts en la matière. Dans le présent document conceptuel, nous proposons de réorienter l’approche traditionnelle axée sur l’évaluation sommative par des examens à enjeux élevés vers l’intégration de la formation, la pratique clinique et la réflexion. Plus précisément, nous proposons un modèle d’octroi progressif du titre de compétence en trois étapes : un titre pour les stagiaires qui ont démontré qu’ils possèdent les connaissances nécessaires pour commencer leur formation en tant que résident étroitement supervisé, un titre de transition pour les stagiaires ayant un portfolio d’apprentissage réflexif qui démontre la compétence clinique requise pour entamer une pratique indépendante avec du soutien et certaines limites, et un titre permettant la pratique pleinement indépendante et non supervisée pour ceux dont le portfolio réflexif démontre une compétence en analyse clinique. Cette proposition a été examinée par un groupe diversifié de 30 stagiaires, praticiens et gestionnaires en éducation médicale. Leurs commentaires ont été analysés et résumés pour donner une idée de l’accueil que la proposition serait susceptible de recevoir de la part du milieu de l’éducation médicale

An Assessment of Risk of Iodine Deficiency Among Pregnant Women in Sarawak, Malaysia

Previous findings from a state-wide Iodine Deficiency Disorders (IDD) study among pregnant women (PW) in Sarawak indicated that PW are at risk of IDD and further assessment is needed. This paper describes the methodology used in conducting this study for an assessment of risk of iodine deficiency among pregnant women in Sarawak, Malaysia. A total of 30 maternal child health care clinics (MCHCs) were selected using probability proportional to population size (PPS) sampling technique. The PW sample size was calculated based on 95% confidence interval (CI), relative precision of 5%, design effect of 2, anticipated IDD prevalence of 65.0% and non-response rate of 20%. Thus, the total sample size required was 750 (25 respondents per selected MCHC). The WHO Expanded Programme on Immunization (EPI) surveys approach was used to randomly select the first respondent and subsequent respondents were chosen until the required number of PW was met. The required data were obtained through: face-to-face interviews (socio-demographic and food frequency questionnaire), clinical assessments (thyroid size, and hyper/hypothyroidism) and biochemical analysis (urine and blood serum). A total of 677 PW responded in the study with a response rate of 90.2%. Majority of the PW were at second gravida, aged 25-29 years old and of Malay ethnicity. The methodology used in this study was based on International guidelines which may provide state's estimates. All the necessary steps were taken into consideration to ensure valid and reliable findings on current iodine status among PW

Physicochemical and sensory analysis of instant cereal beverage incorporated with corncob powder

The primary objectives of this study were to process corncob into corncob powder (CCP) and to apply CCP in the formulation of instant cereal beverage (ICB) in order to produce high fibre ICB, and to investigate the physicochemical and sensory properties of the corncob-based instant cereal beverage. Corncobs were sourced and washed thoroughly before drying and grinding into CCP. CCP was then imparted into ICB formulation in three different ratios (10, 20 and 30% w/w) to partially substitute corn flour in the formulation. All four ICB samples including the commercial counterpart were analysed for their physicochemical and sensory properties. The incorporation of CCP has affected the viscosity, colour and sensory attributes significantly of the produced ICB. Higher contents of CCP in the formulation was found to be responsible for less viscous and browner effect compared to the commercial ICB samples. Formulation of ICB incorporated with 30% w/w CCP had the highest mean scores (6.00, p<0.05) of overall acceptability among all the other formulations and it was comparable to the commercial ICB in the current market

Walking for transportation in Hong Kong Chinese urban elders: a cross-sectional study on what destinations matter and when

published_or_final_versio

Observational Strategies of CMB Temperature and Polarization Interferometry Experiments

We have simulated the interferometric observation of the Cosmic Microwave Background (CMB) temperature and polarization fluctuations. We have constructed data pipelines from the time-ordered raw visibility samples to the CMB power spectra which utilize the methods of data compression, maximum likelihood analysis, and optimal subspace filtering. They are customized for three observational strategies, such as the single pointing, the mosaicking, and the drift-scanning. For each strategy, derived are the optimal strategy parameters that yield band power estimates with minimum uncertainty. The results are general and can be applied to any close-packed array on a single platform such as the CBI and the forthcoming AMiBA experiments. We have also studied the effect of rotation of the array platform on the band power correlation by simulating the CBI single pointing observation. It is found that the band power anti-correlations can be reduced by rotating the platform and thus densely sampling the visibility plane. This enables us to increase the resolution of the power spectrum in the l-space down to the limit of the sampling theorem (Delta l = 226 = pi / theta), which is narrower by a factor of about sqrt{2} than the resolution limit (Delta l = 300) used in the recent CBI single pointing observation. The validity of this idea is demonstrated for a two-element interferometer that samples visibilities uniformly in the uv-annulus. From the fact that the visibilities are the Fourier modes of the CMB field convolved with the beam, a fast unbiased estimator (FUE) of the CMB power spectra is developed and tested. It is shown that the FUE gives results very close to those from the quadratic estimator method without requiring large computer resources even though uncertainties in the results increase.Comment: 33 pages, 6 figures, Accepted version for publication in Astrophysical Journa

The Van der Waals interaction of the hydrogen molecule - an exact local energy density functional

We verify that the van der Waals interaction and hence all dispersion interactions for the hydrogen molecule given by: W"= -{A/R^6}-{B/R^8}-{C/R^10}- ..., in which R is the internuclear separation, are exactly soluble. The constants A=6.4990267..., B=124.3990835 ... and C=1135.2140398... (in Hartree units) first obtained approximately by Pauling and Beach (PB) [1] using a linear variational method, can be shown to be obtainable to any desired accuracy via our exact solution. In addition we shall show that a local energy density functional can be obtained, whose variational solution rederives the exact solution for this problem. This demonstrates explicitly that a static local density functional theory exists for this system. We conclude with remarks about generalising the method to other hydrogenic systems and also to helium.Comment: 11 pages, 13 figures and 28 reference

A systematic review of current knowledge of HIV epidemiology and of sexual behaviour in Nepal

OBJECTIVE: To systematically review information on HIV epidemiology and on sexual behaviour in Nepal with a view to identifying gaps in current knowledge. METHODS: Systematic review covering electronic databases, web-based information, personal contact with experts and hand searching of key journals. RESULTS: HIV-1 seroprevalence has been rising rapidly in association with high-risk behaviours, with current levels of 40% amongst the nation's injecting drug users and approaching 20% amongst Kathmandu's female commercial sex workers (FCSWs). HIV seroprevalence remains low in the general population (0.29% of 15–49 year olds). There are significant methodological limitations in many of the seroprevalence studies identified, and these estimates need to be treated with caution. There are extensive migration patterns both within the country and internationally which provide the potential for considerable sexual networking. However, studies of sexual behaviour have focused on FCSWs and the extent of sexual networks within the general population is largely unknown. CONCLUSIONS: Whilst some of the ingredients are present for an explosive HIV epidemic in Nepal, crucial knowledge on sexual behaviour in the general population is missing. Research on sexual networking is urgently required to guide HIV control in Nepal. There is also a need for further good-quality epidemiological studies of HIV seroprevalence

Modelling of rheological behaviour of pummelo juice concentrates using master-curve

The rheological behaviour of freeze-dried-concentrated pummelo juice was modelled to investigate the effects of temperature and concentration on its fluid type and viscosity using a rotational viscometer at shear rates ranging from 1 to 400 s-1. The effect of concentration measured by its total soluble solids content resulted in the juice concentrates behaving towards shear thinning or pseudoplastic behaviour with flow behaviour index values, n0.98