Neighbourhood deprivation and biomarkers of health in Britain: the mediating role of the physical environment

Background: Neighborhood deprivation has been consistently linked to poor individual health outcomes; however, studies exploring the mechanisms involved in this association are scarce. The objective of this study was to investigate whether objective measures of the physical environment mediate the association between neighborhood socioeconomic deprivation and biomarkers of health in Britain. Methods: We linked individual-level biomarker data from Understanding Society: The UK Household Longitudinal Survey (2010–2012) to neighborhood-level data from different governmental sources. Our outcome variables were forced expiratory volume in 1 s (FEV1%; n=16,347), systolic blood pressure (SBP; n=16,846), body mass index (BMI; n=19,417), and levels of C-reactive protein (CRP; n=11,825). Our measure of neighborhood socioeconomic deprivation was the Carstairs index, and the neighborhood-level mediators were levels of air pollutants (sulphur dioxide [SO2], particulate matter [PM10], nitrogen dioxide [NO2], and carbon monoxide [CO]), green space, and proximity to waste and industrial facilities. We fitted a multilevel mediation model following a multilevel structural equation framework in MPlus v7.4, adjusting for age, gender, and income. Results: Residents of poor neighborhoods and those exposed to higher pollution and less green space had worse health outcomes. However, only SO2 exposure significantly and partially mediated the association between neighborhood socioeconomic deprivation and SBP, BMI, and CRP. Conclusion: Reducing air pollution exposure and increasing access to green space may improve population health but may not decrease health inequalities in Britain

Heterogeneity Effects in Plutonium Contaminated Soil

In 1960 at the McGuire Air Force Base, New Egypt, New Jersey a helium tank ruptured causing a fire to ignite a nearby nuclear tipped Boeing Michigan Aeronautical Research Center (BOMARC) missile. During the fire the weapons grade plutonium (Pu- 239, Pu-240, and Pu-241) ignited and was released into the surrounding area, due to both firefighting efforts, where high pressure water was used to put out the fire, as well as smoke that deposited plutonium as oxidized particles in the surrounding area (Cicotte, 2007). This study investigates the heterogeneity of the distributed plutonium contamination in the McGuire Air Force Base BOMARC missile site soil based upon direct measurements of Am-241, a decay product of Pu-241. The heterogeneity of soil samples taken from the BOMARC missile site was quantified using a conjugate counting method with gamma spectroscopy analysis. Plutonium was shown to be heterogeneously distributed in the BOMARC missile site soil. The physical properties of the heterogeneously distributed plutonium contamination evaluated in this research likely consist of individual particles of plutonium metal alloys. The fate of these particles in the environment as they continuously are exposed to weathering and other physical factors is unknown

Elastic properties of carbon nanotubes and their heterojunctions

Comprehensive studies on the modelling and numerical simulation of the mechanical behaviour under tension, bending and torsion of single-walled carbon nanotubes and their heterojunctions are performed. It is proposed to deduce the mechanical properties of the carbon nanotubes heterojunctions from the knowledge of the mechanical properties of the single-walled carbon nanotubes, which are their constituent key unit

Editorial: Exploring the Technological Needs of Older Adults: Advances in Design, Functionality, User Experience, and Age-Related Cognitive and Sensory Aids to Facilitate Adoption

The rapid advancements in artificial intelligence, robotics, communication, and automation have been the catalyst for the development of a host of new technologies that allow older users to monitor their own health (via wearables), maintain their independence (semi-autonomous driving), social connections (smart home devices), and compensate for a range of age-related sensory changes (hearing aids, smart glasses, augmented displays, etc.). Less well understood is how older users get acquainted with these innovations, how their design and functionality need to be adapted to improve older users’ performance and experience, and which factors and interventions help or hinder technology adoption and use by older users. This Research Topic aims at providing some further insights into these issues

Editorial: Exploring the technological needs of older adults: Advances in design, functionality, user experience, and age-related cognitive and sensory aids to facilitate adoption

Editorial on the Research Topic Exploring the technological needs of older adults: Advances in design, functionality, user experience, and age-related cognitive and sensory aids to facilitate adoptio

Early life characteristics, social mobility during childhood and risk of stroke in later life: findings from a Swedish cohort.

AIMS: To investigate if early life characteristics and social mobility during childhood are associated with incident thrombotic stroke (TS), haemorrhagic stroke (HS) and other stroke (OS). METHODS: Our study population consists of all live births at Uppsala University Hospital in 1915-1929 (Uppsala Birth Cohort; n = 14,192), of whom 5532 males and 5061 females were singleton births and lived in Sweden in 1964. We followed them from 1 January 1964 until first diagnosis of stroke (in the National Patient Register or Causes of Death Register), emigration, death, or until 31 December 2008. Data were analysed using Cox regression, stratifying by gender. RESULTS: Gestational age was negatively associated with TS and OS in women only. Women had increased risk of TS if they were born early preterm (<35 weeks) (HR 1.54 (95% CI 1.02-2.31)) or preterm (35-36 weeks) (HR 1.37 (95% CI 1.03-1.83)) compared to women born at term. By contrast, only women who were early preterm (HR 1.98 (95% CI 1.27-3.10) had an increased risk of OS. Men who were born post-term (⩾42 weeks) had increased risk of HS (HR 1.45 (95% CI 1.04-2.01)) compared with men born at term, with no association for women. TS was associated with social mobility during childhood in women: women whose families were upwardly or downwardly mobile had increased risk of TS compared to women who were always advantaged during childhood. CONCLUSIONS: Gestational age and social mobility during childhood were associated with increased risk of stroke later in life, particularly among women, but there was some heterogeneity between stroke subtypes

Computational modeling of passive transport of functionalized nanoparticles

Functionalized nanoparticles (NPs) are complex objects present in a variety of systems ranging from synthetic grafted nanoparticles to viruses. The morphology and number of the decorating groups can vary widely between systems. Thus, the modeling of functionalized NPs typically considers simplified spherical objects as a first-order approximation. At the nanoscale label, complex hydrodynamic interactions are expected to emerge as the morphological features of the particles change, and they can be further amplified when the NPs are confined or near walls. Direct estimation of these variations can be inferred via diffusion coefficients of the NPs. However, the evaluation of the coefficients requires an improved representation of the NPs morphology to reproduce important features hidden by simplified spherical models. Here, we characterize the passive transport of free and confined functionalized nanoparticles using the Rigid Multi-Blob (RMB) method. The main advantage of RMB is its versatility to approximate the mobility of complex structures at the nanoscale with significant accuracy and reduced computational cost. In particular, we investigate the effect of functional groups' distribution, size, and morphology over nanoparticle translational and rotational diffusion. We identify that the presence of functional groups significantly affects the rotational diffusion of the nanoparticles; moreover, the morphology of the groups and number induce characteristic mobility reduction compared to non-functionalized nanoparticles. Confined NPs also evidenced important alterations in their diffusivity, with distinctive signatures in the off-diagonal contributions of the rotational diffusion. These results can be exploited in various applications, including biomedical, polymer nanocomposite fabrication, drug delivery, and imaging