Evaluation of the immune humoral response of Brazilian patients with Rubinstein-Taybi syndrome

Rubinstein-Taybi syndrome (RTS) is a rare developmental disorder characterized by craniofacial dysmorphisms, broad thumbs and toes, mental and growth deficiency, and recurrent respiratory infections. RTS has been associated with CREBBP gene mutations, but EP300 gene mutations have recently been reported in 6 individuals. In the present study, the humoral immune response in 16 RTS patients with recurrent respiratory infections of possible bacterial etiology was evaluated. No significant differences between patients and 16 healthy controls were detected to explain the high susceptibility to respiratory infections: normal or elevated serum immunoglobulin levels, normal salivary IgA levels, and a good antibody response to both polysaccharide and protein antigens were observed. However, most patients presented high serum IgM levels, a high number of total B cell and B subsets, and also high percentiles of apoptosis, suggesting that they could present B dysregulation. The CREBBP/p300 family gene is extremely important for B-cell regulation, and RTS may represent an interesting human model for studying the molecular mechanisms involved in B-cell development

Ultraviolet and Infrared Divergences in Implicit Regularization: a Consistent Approach

Implicit Regularization is a 4-dimensional regularization initially conceived to treat ultraviolet divergences. It has been successfully tested in several instances in the literature, more specifically in those where Dimensional Regularization does not apply. In the present contribution we extend the method to handle infrared divergences as well. We show that the essential steps which rendered Implicit Regularization adequate in the case of ultraviolet divergences have their counterpart for infrared ones. Moreover we show that a new scale appears, typically an infrared scale which is completely independent of the ultraviolet one. Examples are given.Comment: 9 pages, version to appear in Mod. Phys. Lett.

Symmetries and Ambiguities in the linear sigma model with light quarks

We investigate the role of undetermined finite contributions generated by radiative corrections in a $SU(2)\times SU(2)$ linear sigma model with quarks. Although some of such terms can be absorbed in the renormalization procedure, one such contribution is left in the expression for the pion decay constant. This arbitrariness is eliminated by chiral symmetry.Comment: 9 pages. Added references through the text; an author was added due to an important contribution; corrected typos; the title also was changed. Submitted to Modern Physics Letter

Common Variable Immunodeficiency Associated with Hepatosplenic T-Cell Lymphoma Mimicking Juvenile Systemic Lupus Erythematosus

Common variable immunodeficiency (CVID) is a heterogeneous disorder with susceptibility to infections, autoimmune manifestations, and cancer. To our knowledge, CIVD with T-cell lymphoma mimicking juvenile systemic lupus erythematosus (JSLE) was not described in the literature, and one case was reported herein. An 8-year-old female was admitted in our Pediatric Immunology Unit with a clinical history of hypogammaglobulinemia, recurrent upper respiratory infections, and pneumonias. She had a marked decrease of three serum immunoglobulin isotypes, and the diagnosis of CVID was established. At the age of 17 years, she presented with oral ulceration, nonerosive arthritis, nephritis, serositis, cytopenia, positive antiphospholipid antibodies, and positive antinuclear antibody fulfilling the American College of Rheumatology (ACR) criteria for SLE. She was treated with intravenous methylprednisolone for three consecutive days, and intravenous immunoglobulin, and maintenance therapy of chloroquine, azathioprine and prednisone 40 mg/day. Two months later, she died of septic shock secondary to acute pneumonia. The necropsy showed hepatosplenic T-cell lymphoma with diffuse involvement of bone marrow, spleen, liver, and lungs. The lymphoma cells were positive for CD3 immunostaining and negative for CD20 and lysozyme. In conclusion, the association of CVID and hepatosplenic T-cell lymphoma may simulate JSLE diagnosis

Systematic Implementation of Implicit Regularization for Multi-Loop Feynman Diagrams

Implicit Regularization (IReg) is a candidate to become an invariant framework in momentum space to perform Feynman diagram calculations to arbitrary loop order. In this work we present a systematic implementation of our method that automatically displays the terms to be subtracted by Bogoliubov's recursion formula. Therefore, we achieve a twofold objective: we show that the IReg program respects unitarity, locality and Lorentz invariance and we show that our method is consistent since we are able to display the divergent content of a multi-loop amplitude in a well defined set of basic divergent integrals in one loop momentum only which is the essence of IReg. Moreover, we conjecture that momentum routing invariance in the loops, which has been shown to be connected with gauge symmetry, is a fundamental symmetry of any Feynman diagram in a renormalizable quantum field theory

Design and development of an Automatic Optical Inspection (AOI) system support based on digital manufacturing

Visual inspection of components, subassemblies and final products is an essential step to ensure the quality control of ready-to-market electronic components. In many manufacturing plants, including Bosch Car Multimedia S.A., typically automated systems for automatic optical inspection (AOI) are implemented at several workstations to perform visual verification and validation in between critical production tasks. At Bosch Car Multimedia S.A., the AOI system includes a metallic support frame that accommodates a series of components for the function of AOI. The support frame is attached to a robotic arm for controlled movement. As the AOI is a rather fast-moving process, deformation of components may occur during monitoring due to the high acceleration of the robotic arm while operating. In addition to this issue, the existent AOI system includes a high number of components and connections which increase complexity for assembly and disassembly operations. This paper presents the redesign for enhanced performance and functionality of a AOI metallic support frame by resourcing to the generative design (GD) exploration method. Furthermore, additive manufacturing technology, based in selective laser sintering (SLS) of polymeric powders, was used for the production of a new lightweight and reliable version of an AOI support frame. The alternative AOI support frame configuration consists of a single consolidated polymeric component that enabled an overall weight decrease above 30% and a reduction of main components and total number of parts of approximately 89% and ~77%, respectively.FEDER - Federación Española de Enfermedades Raras(undefined)European Structural and Investment Funds in the FEDER component, through the Operational Competitiveness and Internationalization Programme (COMPETE 2020) [Project nº 039479

Influence of thickness and coatings morphology in the antimicrobial performance of zinc oxide coatings

"Author's copy"In this research work, the production of undoped and silver (Ag) doped zinc oxide (ZnO) thin films for food-packaging applications were developed. The main goal was to determine the influence of coatings morphology and thickness on the antimicrobial performance of the produced samples. The ZnO based thin films were deposited on PET (Polyethylene terephthalate) substrates by means of DC reactive magnetron sputtering. The thin films were characterized by optical spectroscopy, X-Ray Diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Scanning Electron Microscopy (SEM). The antimicrobial performance of the undoped and Ag-doped ZnO thin films was also evaluated. The results attained have shown that all the deposited zinc oxide and Ag-doped ZnO coatings present columnar morphology with V-shaped columns. The increase of ZnO coatings thickness until 200 nm increases the active surface area of the columns. The thinner samples (50 and 100 nm) present a less pronounced antibacterial activity than the thickest ones (200–600 nm). Regarding Ag-doped ZnO thin films, it was verified that increasing the silver content decreases the growth rate of Escherichia coli and decreases the amount of bacteria cells present at the end of the experiment.The work described in this paper was supported by project NANOPACKSAFER: NANO-engineered PACKaging systems for improving quality, SAFEty and health characteristics of foods, Portugal-Spain International Nanotechnology Laboratory Nanotechnology Projects Call; and also by the FEDER funding through the COMPETE program and FCT PEst-C/BIA/UI4050/2011 project