63 research outputs found
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Synthesis and characterization of polyolefin-graft-oligopeptide polyelectrolytes
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Microphase separated structures in the solid and molten states of double-crystal graft copolymers of polyethylene and poly(ethylene oxide)
Relative Performance of Alkynes in Copper-Catalyzed Azide–Alkyne Cycloaddition
Copper-catalyzed azide–alkyne
cycloaddition (CuAAC) has
found numerous applications in a variety of fields. We report here
only modest differences in the reactivity of various classes of terminal
alkynes under typical bioconjugative and preparative organic conditions.
Propargyl compounds represent an excellent combination of azide reactivity,
ease of installation, and cost. Electronically activated propiolamides
are slightly more reactive, at the expense of increased propensity
for Michael addition. Certain alkynes, including tertiary propargyl
carbamates, are not suitable for bioconjugation due to copper-induced
fragmentation. A fluorogenic probe based on such reactivity is available
in one step from rhodamine 110 and can be useful for optimization
of CuAAC conditions
Analysis of the immission concentrations of BTXE aromatics and carbon black components in urban environments
Encapsidated Atom-Transfer Radical Polymerization in Qβ Virus-like Nanoparticles
Virus-like particles (VLPs) are unique macromolecular structures that hold great promise in biomedical and biomaterial applications. The interior of the 30 nm-diameter Qβ VLP was functionalized by a three-step process: (1) hydrolytic removal of endogenously packaged RNA, (2) covalent attachment of initiator molecules to unnatural amino acid residues located on the interior capsid surface, and (3) atom-transfer radical polymerization of tertiary amine-bearing methacrylate monomers. The resulting polymer-containing particles were moderately expanded in size; however, biotin-derivatized polymer strands were only very weakly accessible to avidin, suggesting that most of the polymer was confined within the protein shell. The polymer-containing particles were also found to exhibit physical and chemical properties characteristic of positively charged nanostructures, including the ability to easily enter mammalian cells and deliver functional small interfering RNA
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