Mitigation of the LHC Inverse Problem

The LHC inverse problem refers to the difficulties in determining the parameters of an underlying theory from data (to be) taken by the LHC experiments: if they find signals of new physics, and an underlying theory is assumed, could its parameters be determined uniquely, or do different parameter choices give indistinguishable experimental signatures? This inverse problem was studied before for a supersymmetric Standard Model with 15 free parameters. This earlier study found 283 indistinguishable pairs of parameter choices, called degenerate pairs, even if backgrounds are ignored. We can resolve all but 23 of those pairs by constructing a true \chi^2 distribution using mostly counting observables. The elimination of systematic errors would even allow separating the residual degeneracies. Taking the Standard Model background into account we still can resolve 237 of the 283 "degenerate" pairs. This indicates that (some of) our observables should also be useful for the purpose of determining the values of SUSY parameters.Comment: 32 pages, 13 figures, typo in (3.6) corrected, version to appear in Phys. Rev.

Light Stop Searches at the LHC in Events with two b-Jets and Missing Energy

We propose a new method to discover light top squarks (stops) in the co-annihilation region at the Large Hadron Collider (LHC). The bino-like neutralino is the lightest supersymmetric particle (LSP) and the lighter stop is the next-to-LSP. Such scenarios can be consistent with electroweak baryogenesis and also with dark matter constraints. We consider the production of two stops in association with two b-quarks, including pure QCD as well as mixed electroweak-QCD contributions. The stops decay into a charm quark and the LSP. For a higgsino-like light chargino the electroweak contributions can exceed the pure QCD prediction. We show the size of the electroweak contributions as a function of the stop mass and present the LHC discovery reach in the stop-neutralino mass plane.Comment: 12 pages, 10 figure

Electroweak Contributions to Squark Pair Production at the LHC

In this paper we compute electroweak contributions to the production of squark pairs at hadron colliders. These include the exchange of electroweak gauge bosons in the s-channel as well as electroweak gaugino exchange in the t- and/or u-channel. In many cases these can interfere with the dominant QCD contributions. As a result, we find sizable contributions to the production of two SU(2) doublet squarks. At the LHC, they amount to 10 to 20% for typical mSUGRA (or CMSSM) scenarios, but in more general scenarios they can vary between -40 and +55%, depending on size and sign of the SU(2) gaugino mass. The electroweak contribution to the total squark pair production rate at the LHC is about 3.5 times smaller.Comment: 28 pages, 9 figure

Hunting for CDF Multi-Muon "Ghost" Events at Collider and Fixed-Target Experiments

In 2008 the CDF collaboration discovered a large excess of events containing two or more muons, at least one of which seemed to have been produced outside the beam pipe. We investigate whether similar "ghost" events could (and should) have been seen in already completed experiments. The CDF di-muon data can be reproduced by a simple model where a relatively light X particle undergoes four-body decay. This model predicts a large number of ghost events in Fermilab fixed-target experiments E772, E789 and E866, applying the cuts optimized for analyses of Drell-Yan events. A correct description of events with more than two muons requires a more complicated model, where two X particles are produced from a very broad resonance Y. This model can be tested in fixed-target experiments only if the cut on the angles, or rapidities, of the muons can be relaxed. Either way, the UA1 experiment at the CERN ppbar collider should have observed O(100) ghost events.Comment: 15 pages, 9 figure

Rapidity Gap Events in Squark Pair Production at the LHC

The exchange of electroweak gauginos in the $t-$ or $u-$channel allows squark pair production at hadron colliders without color exchange between the squarks. This can give rise to events where little or no energy is deposited in the detector between the squark decay products. We discuss the potential for detection of such rapidity gap events at the Large Hadron Collider (LHC). Our numerical analysis is divided into two parts. First, we evaluate in a simplified framework the rapidity gap signal at the parton level. The second part covers an analysis with full event simulation using PYTHIA as well as Herwig++, but without detector simulation. We analyze the transverse energy deposited between the jets from squark decay, as well as the probability of finding a third jet in between the two hardest jets. For the mSUGRA benchmark point SPS1a we find statistically significant evidence for a color singlet exchange contribution. The systematical differences between current versions of PYTHIA and HERWIG++ are larger than the physical effect from color singlet exchange; however, these systematic differences could be reduced by tuning both Monte Carlo generators on normal QCD di--jet data.Comment: 23 pages, 10 figure

Second-line high-dose chemotherapy in patients with mediastinal and retroperitoneal primary non-seminomatous germ cell tumors: the EBMT experience

Background: Results of second-line chemotherapy in patients with extragonadal non-seminomatous germ cell tumor (NSGCT) appear inferior to results in testicular NSGCT. Patients with retroperitoneal NSGCT achieve a comparable long-term survival rate of 30%, but the salvage rates of patients with mediastinal primary are less than 10%. We conducted a retrospective analysis on patients with mediastinal and retroperitoneal NSGCT treated with second-line high-dose chemotherapy (HDCT) registered with the European Group for Blood and Marrow Transplantation (EBMT). Patients and methods: Between 1987 and 1999, 59 registered patients with retroperitoneal (n=37) and mediastinal (n=22) primary NSGCT, median age 28 years (range 18-60), were treated with second-line HDCT. All had received cisplatin-containing chemotherapy as first-line treatment. Results: Toxic death occurred in three cases (5%). With a median follow-up of 58 months (range 14-114), 18/59 patients (30%) continue to be disease-free. Of three patients who had a disease recurrence after HDCT, one patient achieved a disease-free status with further chemotherapy and surgery. In total, 19 patients (32%) are currently disease-free. Sixteen of 37 patients (43%) with retroperitoneal NSGCT, and three of 22 patients (14%) with mediastinal NSGCT are currently alive and disease-free. Conclusions: Second-line HDCT might represent a possible option for patients with retroperitoneal primary NSGCT. New salvage strategies are needed for patients with mediastinal NSGC

Hadronic production of bottom-squark pairs with electroweak contributions

We present the complete computation of the tree-level and the next-to-leading order electroweak contributions to bottom-squark pair production at the LHC. The computation is performed within the minimal supersymmetric extension of the Standard Model. We discuss the numerical impact of these contributions in several supersymmetric scenarios.Comment: 33 pages, v2: preprint numbers correcte

Constraints on supersymmetry with light third family from LHC data

We present a re-interpretation of the recent ATLAS limits on supersymmetry in channels with jets (with and without b-tags) and missing energy, in the context of light third family squarks, while the first two squark families are inaccessible at the 7 TeV run of the Large Hadron Collider (LHC). In contrast to interpretations in terms of the high-scale based constrained minimal supersymmetric standard model (CMSSM), we primarily use the low-scale parametrisation of the phenomenological MSSM (pMSSM), and translate the limits in terms of physical masses of the third family squarks. Side by side, we also investigate the limits in terms of high-scale scalar non-universality, both with and without low-mass sleptons. Our conclusion is that the limits based on 0-lepton channels are not altered by the mass-scale of sleptons, and can be considered more or less model-independent.Comment: 20 pages, 8 figures, 2 tables. Version published in JHE

NLL soft and Coulomb resummation for squark and gluino production at the LHC

We present predictions of the total cross sections for pair production of squarks and gluinos at the LHC, including the stop-antistop production process. Our calculation supplements full fixed-order NLO predictions with resummation of threshold logarithms and Coulomb singularities at next-to-leading logarithmic (NLL) accuracy, including bound-state effects. The numerical effect of higher-order Coulomb terms can be as big or larger than that of soft-gluon corrections. For a selection of benchmark points accessible with data from the 2010-2012 LHC runs, resummation leads to an enhancement of the total inclusive squark and gluino production cross section in the 15-30 % range. For individual production processes of gluinos, the corrections can be much larger. The theoretical uncertainty in the prediction of the hard-scattering cross sections is typically reduced to the 10 % level.Comment: 45 pages, 16 Figures, LaTex. v2: published version. Grids with numerical results for the NLL cross sections for squark and gluino production at the 7/8 TeV LHC are included in the submission and are also available at http://omnibus.uni-freiburg.de/~cs1010/susy.htm

γ-Catenin-Dependent Signals Maintain BCR-ABL1⁺ B Cell Acute Lymphoblastic Leukemia.

The BCR-ABL1 fusion protein is the cause of chronic myeloid leukemia (CML) and of a significant fraction of adult-onset B cell acute lymphoblastic leukemia (B-ALL) cases. Using mouse models and patient-derived samples, we identified an essential role for γ-catenin in the initiation and maintenance of BCR-ABL1 <sup>+</sup> B-ALL but not CML. The selectivity was explained by a partial γ-catenin dependence of MYC expression together with the susceptibility of B-ALL, but not CML, to reduced MYC levels. MYC and γ-catenin enabled B-ALL maintenance by augmenting BIRC5 and enforced BIRC5 expression overcame γ-catenin loss. Since γ-catenin was dispensable for normal hematopoiesis, these lineage- and disease-specific features of canonical Wnt signaling identified a potential therapeutic target for the treatment of BCR-ABL1 <sup>+</sup> B-ALL