5,623 research outputs found
Kaon and production vs Participants in Nuclear Collisions
Data on kaon and production in nuclear collisions as a function of
centrality are analysed both at AGS and SPS energy range. We compare the
results of several experiments, looking for common trend in `participant
scaling' of production yields. We find a smooth description of scaled kaon and
yields as a function of participant density. We also show a participant
density dependence of kaons and produced in the forward hemisphere for
proton-nucleus collisions.Comment: Proceedings of the International Conference on Strangeness in Quark
Matter, 20-25 July 2000, Berkeley, CA. To appear in Journal of Physics G:
Nuclear and Particle Physic
Reply to Comment of Gazdzicki and Heinz on Strangeness Enhancement in and
The Comment of Gazdzicki and Heinz is flawed because their assumed baryon
stopping power in is inconsistent with data and because they ignored half
the analysis based on the VENUS model. The Comment continues the misleading
presentation of strangeness enhancement by focusing on ratios of integrated
yields. Those ratios discard essential experimental information on the rapidity
dependence of produced and obscure discrepancies between different
data sets. Our conclusion remains that the NA35 minimum bias data on
indicate an anomalous enhancement of central
rapidity strangeness in few nucleon reactions that points to non-equilibrium
dynamics as responsible for strangeness enhancement in nuclear reactions.Comment: revtex file, 6 pages, submitted to Phys. Rev.
Antideuteron and deuteron production in mid-central Pb+Pb collisions at 158 GeV
Production of deuterons and antideuterons was studied by the NA49 experiment
in the 23.5% most central Pb+Pb collisions at the top SPS energy of
=17.3 GeV. Invariant yields for and were measured
as a function of centrality in the center-of-mass rapidity range .
Results for together with previously published
measurements are discussed in the context of the coalescence model. The
coalescence parameters were deduced as a function of transverse momentum
and collision centrality.Comment: 9 figure
Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells.
Wnt5a can activate Rho GTPases in chronic lymphocytic leukemia (CLL) cells by inducing the recruitment of ARHGEF2 to ROR1. Mass spectrometry on immune precipitates of Wnt5a-activated ROR1 identified 14-3-3ζ, which was confirmed by co-immunoprecipitation. The capacity of Wnt5a to induce ROR1 to complex with 14-3-3ζ could be blocked in CLL cells by treatment with cirmtuzumab, a humanized mAb targeting ROR1. Silencing 14-3-3ζ via small interfering RNA impaired the capacity of Wnt5a to: (1) induce recruitment of ARHGEF2 to ROR1, (2) enhance in vitro exchange activity of ARHGEF2 and (3) induce activation of RhoA and Rac1 in CLL cells. Furthermore, CRISPR/Cas9 deletion of 14-3-3ζ in ROR1-negative CLL cell-line MEC1, and in MEC1 cells transfected to express ROR1 (MEC1-ROR1), demonstrated that 14-3-3ζ was necessary for the growth/engraftment advantage of MEC1-ROR1 over MEC1 cells. We identified a binding motif (RSPS857SAS) in ROR1 for 14-3-3ζ. Site-directed mutagenesis of ROR1 demonstrated that serine-857 was required for the recruitment of 14-3-3ζ and ARHGEF2 to ROR1, and activation of RhoA and Rac1. Collectively, this study reveals that 14-3-3ζ plays a critical role in Wnt5a/ROR1 signaling, leading to enhanced CLL migration and proliferation
Measurement of event-by-event transverse momentum and multiplicity fluctuations using strongly intensive measures and in nucleus-nucleus collisions at the CERN Super Proton Synchrotron
Results from the NA49 experiment at the CERN SPS are presented on
event-by-event transverse momentum and multiplicity fluctuations of charged
particles, produced at forward rapidities in central Pb+Pb interactions at beam
momenta 20, 30, 40, 80, and 158 GeV/c, as well as in systems of
different size (, C+C, Si+Si, and Pb+Pb) at 158 GeV/c. This publication
extends the previous NA49 measurements of the strongly intensive measure
by a study of the recently proposed strongly intensive measures of
fluctuations and . In the explored kinematic
region transverse momentum and multiplicity fluctuations show no significant
energy dependence in the SPS energy range. However, a remarkable system size
dependence is observed for both and , with the
largest values measured in peripheral Pb+Pb interactions. The results are
compared with NA61/SHINE measurements in collisions, as well as with
predictions of the UrQMD and EPOS models.Comment: 12 pages, 14 figures, to be submitted to PR
System-size and centrality dependence of charged kaon and pion production in nucleus-nucleus collisions at 40A GeV and158A GeV beam energy
Measurements of charged pion and kaon production are presented in centrality
selected Pb+Pb collisions at 40A GeV and 158A GeV beam energy as well as in
semi-central C+C and Si+Si interactions at 40A GeV. Transverse mass spectra,
rapidity spectra and total yields are determined as a function of centrality.
The system-size and centrality dependence of relative strangeness production in
nucleus-nucleus collisions at 40A GeV and 158A GeV beam energy are derived from
the data presented here and published data for C+C and Si+Si collisions at 158A
GeV beam energy. At both energies a steep increase with centrality is observed
for small systems followed by a weak rise or even saturation for higher
centralities. This behavior is compared to calculations using transport models
(UrQMD and HSD), a percolation model and the core-corona approach.Comment: 32 pages, 14 figures, 4 tables, typo table II correcte
Semi-Inclusive Lambda and Kshort Production in p-Au Collisions at 17.5 GeV/c
The first detailed measurements of the centrality dependence of strangeness
production in p-A collisions are presented. Lambda and Kshort dn/dy
distributions from 17.5 GeV/c p-Au collisions are shown as a function of "grey"
track multiplicity and the estimated number of collisions, nu, made by the
proton. The nu dependence of the Lambda yield deviates from a scaling of p-p
data by the number of participants, increasing faster than this scaling for
nu<=5 and saturating for larger nu. A slower growth in Kshort multiplicity with
nu is observed, consistent with a weaker nu dependence of K-Kbar production
than Y-K production.Comment: 5 pages, 3 figures, formatted with RevTex, current version has
enlarged figure catpion
Strangeness Enhancement in p-A Collisions: Consequences for the Interpretation of Strangeness Production in A-A Collisions
Published measurements of semi-inclusive Lambda production in p-Au collisions
at the AGS are used to estimate the yields of singly strange hadrons in
nucleus-nucleus A-A collisions. Results of a described extrapolation technique
are shown and compared to measurements of K+ production in Si-Al, Si-Au, and
Au-Au collisions at the AGS and net Lambda production in Su-Su, S-Ag, Pb-Pb,
and inclusive p-A collisions at the SPS. The extrapolations can account for
more than 75% of the measured strange particle yields in all of the studied
systems except for very central Au-Au collisions at the AGS where RQMD
comparisons suggest large re-scattering contributions.Comment: 9 pages, 4 figure
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