Gun Carrying Among Adolescents

Outdoor education is a promising educational field that can support indoor education and provide benefits beyond the evidentknowledge. Outdoor and indoor education together can formulate the ground for an integrated learning. In Greece, like manycountries, outdoor education and its potential contribution to the learning process have not been clearly and intentionally testedyet, even though the country tends to follow a progressive educational philosophy. This research focuses on the subject ofmathematics and explores the connections between the existing philosophy and practices of mathematics education in Greece andoutdoor education theory and practice. Following the method of content analysis, the connections were identified through theexistence of basic outdoor education concepts in the mathematics textbooks of the last three grades of primary school. Althoughthe expectations, because of the lack of personal experiences, could not be high, the application of outdoor education seems to befar from impossible in Greece. It could rather flourish even without any changes in the books, when its potentialities are realizedby the teachers

Analysis of the plasminogen activator activity of the human glomerulus

Analysis of the plasminogen activator activity of the human glomerulus. An assay was developed to measure plasminogen activator activity from isolated human glomeruli. Activator was extracted from individual glomeruli with 0.2 M phosphate-buffered saline, pH 7.4 (PBS), containing 0.01% Triton X-100 and quantitated in 125I-fibrin films. Quenching studies using antibodies to tissue plasminogen activator and urokinase revealed that the extracted glomerular plasminogen activator activity contained both tissue plasminogen activator and urokinase. Monoclonal and polyclonal antibodies raised to tissue plasminogen activator demonstrated low-level inhibition of urokinase activity and monoclonal and polyclonal antibodies to urokinase demonstrated low-level inhibition of tissue plasminogen activator activity. The assay should be applicable to the study of glomerular plasminogen activator activity in experimental and human kidney diseases. The detection of antibody cross-reactivity to tissue plasminogen activator and urokinase may be related to the sensitivity of the 125I-fibrin film assay and to the structural similarities of these activators

COMPARAÇÃO DE TRÊS MÉTODOS DE REFRIGERAÇÃO DO SÊMEN OVINO PELO PERÍODO DE 24 E 48 HORAS.

A manutenção do sêmen ovino refrigerado apresenta vantagens quando comparado ao sêmen fresco e congelado. O objetivo deste trabalho foi avaliar três equipamentos de refrigeração, à 5°C, do sêmen ovino com base nas análises in vitro da motilidade total, vigor, morfologia espermática e teste hiposmótico (HOST). As amostras seminais foram refrigeradas em geladeira (G1), equipamento automatizado (G2) e dispositivo móvel (G3) durante 24 horas (MI) e 48 horas (MIII). Foi realizado teste de exaustão pela incubação por quatro horas à 37°C das amostras mantidas refrigeradas por 24 horas (MII) e 48 horas (MIV). Não houve diferença (P>0,05) entre os equipamentos de refrigeração em todos os parâmetros analisados. Conclui-se que os três métodos de refrigeração foram eficientes em manter os parâmetros in vitro de qualidade espermática similares ao sêmen fresco até 24 horas. Após 48 horas de refrigeração, em todos os métodos, houve decréscimo (P0,05) do vigor, morfologia espermática ou HOST

The Ethics of Delusional Belief

In this paper we address the ethics of adopting delusional beliefs and we apply consequentialist and deontological considerations to the epistemic evaluation of delusions. Delusions are characterised by their epistemic shortcomings and they are often defined as false and irrational beliefs. Despite this, when agents are overwhelmed by negative emotions due to the effects of trauma or previous adversities, or when they are subject to anxiety and stress as a result of hypersalient experience, the adoption of a delusional belief can prevent a serious epistemic harm from occurring. For instance, delusions can allow agents to remain in touch with their environment overcoming the disruptive effect of negative emotions and anxiety. Moreover, agents are not blameworthy for adopting their delusions if their ability to believe otherwise is compromised. There is evidence suggesting that no evidence-related action that would counterfactually lead them to believe otherwise is typically available to them. The lack of ability to believe otherwise, together with some other conditions, implies that the agents are not blameworthy for their delusions. The examination of the epistemic status of delusions prompts us to acknowledge the complexity and contextual nature of epistemic evaluation, establish connections between consequentialist and deontological frameworks in epistemology, and introduce the notion of epistemic innocence into the vocabulary of epistemic evaluatio

Wnt signaling in breast cancer: have we come full circle?

Since the original identification of Wnt1 as a mammary oncogene in mouse mammary tumor virus infected mice, questions have been asked about its relevance to human breast cancer. Wnt1 is now known to be one of a large family of Wnt genes encoding structurally similar secreted signaling proteins, several of which are functionally redundant. The principal intracellular signaling pathway activated by these proteins has been elucidated in recent years. Components of this pathway include proto-oncogene products, such as β-catenin, and tumor suppressor proteins such as APC. Although WNT1 itself has not been implicated in human breast neoplasms, it has been reported that other WNT genes are sometimes overexpressed in human breast cancer and there is growing evidence that downstream components of the Wnt signaling pathway are activated in a significant proportion of breast tumors

Transabdominal Preperitoneal Repair for Obturator Hernia

信州大学博士（医学）・学位論文・平成23年3月31日授与（甲第889号）・横山隆秀Background A laparoscopic surgical approach for obturator hernia (OH) repair is uncommon. The aim of the present study was to assess the effectiveness of laparoscopic transabdominal preperitoneal (TAPP) repair for OH. Methods From 2001 to May 2010, 659 patients with inguinal hernia underwent TAPP repair at in our institutes. Among these, the eight patients with OH were the subjects of this study. Results Three of the eight patients were diagnosed as having occult OH, and the other five were diagnosed preoperatively, by ultrasonography and/or computed tomography, as having strangulated OH. Bilateral OH was found in five patients (63%), and combined groin hernias, either unilaterally or bilaterally, were observed in seven patients (88%), all of whom had femoral hernia. Of the five patients with bowel obstruction at presentation, four were determined not to require resection after assessment of the intestinal viability by laparoscopy. There was one case of conversion to a two-stage hernia repair performed to avoid mesh contamination: addition of mini-laparotomy, followed by extraction of the gangrenous intestine for resection and anastomosis with simple peritoneal closure of the hernia defect in the first stage, and a Kugel hernia repair in the second stage. There was no incidence of postoperative morbidity, mortality, or recurrence. Conclusions Because TAPP allows assessment of not only the entire groin area bilaterally but also simultaneous assessment of the viability of the incarcerated intestine with a minimum abdominal wall defect, we believe that it is an adequate approach to the treatment of both occult and acutely incarcerated OH. Two-stage hernia repair is technically feasible in patients requiring resection of the incarcerated intestine.ArticleWORLD JOURNAL OF SURGERY. 35(10):2323-2327 (2011)journal articl