Modelling the polymer migration phenomena in DNA-laden flows

This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.Cross-stream migration of macromolecules transported in a fluid flow is typically encountered in microfluidic applications. This experimentally observed phenomenon leads to a decrease of the nearwall macromolecule concentration which can be detrimental in applications relying on a high intensity of polymer reactions in the near-wall zone, such as DNA-based bio-sensors. Despite a significant body of experimental, theoretical and numerical research, there is no consensus regarding the nature of this phenomenon. In this paper a meta-modelling approach for macromolecule motion in the flow is presented. It is demonstrated that the hydrodynamic interaction resulting from the incorporation of Saffman lift force, together with Faxen correction to Stokes drag causes migration of DNA molecules towards the middle of a pressure driven micro-flow, which is in agreement with experimental observations. The results suggest that the migration can occur due to macromolecule-flow rather than macromolecule-wall interaction.This work has been supported in part by the European Commission under the 6th Framework Program (Project: DINAMICS, NMP4-CT-2007-026804

Use of susceptibility scoring in conjunction with the genotypic transmission disequilibrium test

We explored the utility of selecting a genetically predisposed subgroup to increase the finding of a genetic signal in the Genetic Analysis Workshop 14 Collaborative Study on the Genetics of Alcoholism dataset. A subgroup of affected probands with low environmental risk exposures was defined using a susceptibility score calculated from an environmental risk model. Thirty-nine probands with highly positive scores were selected, along with their parents, for use in a genotypic transmission disequilibrium test (TDT) test. We compared the results of the genotypic TDT in this subgroup to the TDT results using all probands and their parents. For some markers, the susceptibility scoring approach resulted in smaller p-values, while for other markers, evidence for a genetic signal weakened. Further explorations into genetic and environmental population characteristics that benefit from this approach are warranted

VLBI Probes of Jet Physics in Neutrino-Candidate Blazars

In recent years, evidence has accumulated that some high-energy cosmic neutrinos can be associated with blazars. The strongest evidence for an individual association was found in the case of the blazar TXS 0506+056 in 2017. In July 2019, another track-like neutrino event (IC190730A) was found spatially coincident with the well-known bright flat-spectrum radio quasar PKS 1502+106. PKS 1502+106 was not found to be in a particularly elevated gamma-ray state, but exhibited a remarkably bright radio outburst at the time of the neutrino detection, similar to TXS 0506+056. We have performed a multi-frequency VLBI study from 15 GHz up to 86 GHz on TXS 0506+056, PKS 1502+106 and one additional neutrino-candidate blazar (PKS 0215+015) to study the radio structure of neutrino candidate blazars in response to their neutrino association. We have obtained target of opportunity observations with the VLBA for all three sources within $\sim$1 month from their associated neutrino events and are performing multi-epoch studies of the jet kinematics at 15 GHz as part of the MOJAVE program. Here, we present first results on TXS 0506+056 at 86 GHz and one additional 43 GHz image obtained 27 days after IC170922A, closer in time to the neutrino event than previously published images. We also give an overview about our recent work on PKS 1502+106 and PKS 0215+015.Comment: 8 pages, 1 figure, 1 table, Proceedings of 38th International Cosmic Ray Conference (ICRC2023

P2‐540: Polygenetic Risk For Alzheimer’S Disease And Dementia Status

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153242/1/alzjjalz2019062948.pd

A study on selective transformation of norbornadiene into fluorinated cyclopentane-fused isoxazolines

This work presents an examination of the selective functionalization of norbornadiene through nitrile oxide 1,3-dipolar cycloaddition/ring-opening metathesis (ROM)/cross-metathesis (CM) protocols. Functionalization of commercially available norbornadiene provided novel bicyclic scaffolds with multiple stereogenic centers. The synthesis involved selective cycloadditions, with subsequent ROM of the formed cycloalkene-fused isoxazoline scaffolds and selective CM by chemodifferentiation of the olefin bonds of the resulting alkenylated derivatives. Various experimental conditions were applied for the CM transformations with the goal of exploring substrate and steric effects, catalyst influence and chemodifferentiation of the olefin bonds furnishing the corresponding functionalized, fluorine-containing isoxazoline derivatives

P3‐558: Exposures Prior To Age 16 Are Associated With Dementia Status In The Health And Retirement Study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152762/1/alzjjalz2019063595.pd

Risk of non-Hodgkin lymphoma associated with occupational exposure to solvents,metals, organic dusts and PCBs (Australia)

Objective: Several studies have suggested that there is an occupational component to the causation of non-Hodgkin lymphoma (NHL). We aimed to use accurate means to assess occupational exposures to solvents, metals, organic dusts and polychlorinated biphenyls (PCBs) in a case-control study. Methods: Cases were incident NHLs during 2000 and 2001 in two regions of Australia. Controls were randomly selected from the electoral roll and frequency matched to cases by age, sex and region. A detailed occupational history was taken from each subject. For jobs with likely exposure to the chemicals of interest, additional questions were asked by telephone interview using modified job specific modules. An expert allocated exposures using the information in the job histories and the interviews. Odds ratios were calculated for each exposure adjusting for age, sex, region and ethnic origin. Results: 694 cases and 694 controls (70% and 45% respectively of those potentially eligible) participated. The risk of NHL was increased by about 30% for exposure to any solvent with a dose response relationship, subgroup analysis showed the finding was restricted to solvents other than benzene. Exposure to wood dust also increased the risk of NHL slightly. Exposures to other organic dusts, metals, and PCBs were not strongly related to NHL. Conclusions: The risk of NHL appears to be increased by exposure to solvents other than benzene and possibly to wood dust