Ethnicity and alcohol: a review of the UK literature

This literature review draws together recorded drinking patterns among minority ethnic groups in the UK over the last 15 years and considers the evidence for service provision and support. A recommendation in implementing the Government’s alcohol strategy, Safe. Sensible. Social. is to assess the need for and develop provision for black and minority ethnic groups. This need is heightened by the growing minority ethnic population and changes in consumption levels that may emerge over generations. The review explores differences in drinking patterns by ethnicity and the cultural and social contexts around which the use of alcohol is established and maintained. This review: • describes drinking levels as reported in national surveys and local research; • considers processes and infl uences that help to explain why drinking rates among ethnic groups in a new country may change over time; • examines help-seeking, support and service provision for minority ethnic groups; • examines the extent to which services are equipped to respond to the needs of minority ethnic groups

Prolonging assembly through dissociation:A self assembly paradigm in microtubules

We study a one-dimensional model of microtubule assembly/disassembly in which GTP bound to tubulins within the microtubule undergoes stochastic hydrolysis. In contrast to models that only consider a cap of GTP-bound tubulin, stochastic hydrolysis allows GTP-bound tubulin remnants to exist within the microtubule. We find that these buried GTP remnants enable an alternative mechanism of recovery from shrinkage, and enhances fluctuations of filament lengths. Under conditions for which this alternative mechanism dominates, an increasing depolymerization rate leads to a decrease in dissociation rate and thus a net increase in assembly.Comment: accepted for publication in Physical Review

The role of training in IBA implementation beyond primary health care settings in the UK

There has been a considerable drive to encourage a wide range of professional groups to incorporate alcohol screening (or identification) and brief advice (IBA) into their everyday practice. This article aims to examine the role of training in promoting IBA delivery in contexts outside primary care and other health settings. The data are drawn mainly from a structured online survey supplemented by illustrative material from nine qualitative interviews and insights from an expert workshop. Findings support the results from other research that issues relating to role relevance and role security continue to act as barriers to professional change. Furthermore, issues of organisational commitment and organisational barriers are insufficiently addressed in strategy to promote wider use of IBA. The article concludes that development of appropriate training for alcohol IBA needs to take account of the role of IBA within a complex interactive system of related services and help seeking pathways and consider how training can contribute to changing both professional attitudes and behaviours and organisational approaches to implementing and sustaining IBA in everyday professional practice

"But no one told me it’s okay to not drink": a qualitative study of young people who drink little or no alcohol

Young people’s drinking is a matter of social, media and political concern and the focus of much policy activity within the UK. Little consideration has been given to the fact that some young people choose to drink little or not all and our knowledge and understanding of their choices and how they manage not drinking is limited. Nor has much attention been paid to the possibility that the insights of young light and non-drinkers could be useful when thinking about how to change the prevailing drinking culture, but if we are to gauge and engage with the current culture of consumption then we need to understand all parts of it (Pattenden et al., 2008). This qualitative study of young people (aged 16-25) who drink little or no alcohol aimed to further understanding of their lives and choices. The results highlight that choosing not to drink or drink lightly is a positive choice made for diverse reasons with the strongest messages and influences coming from real life observations. Young people develop strategies to manage not drinking or drinking lightly. Alcohol education messages need to present not drinking as a valid option to young people, parents and society more broadly

Delivering alcohol IBA: is there a case for mainstreaming? Insights from an expert workshop and from the published literature

Identification and brief advice (IBA) has been widely advocated as a cost effective intervention to address problem drinking. Evidence for the effectiveness of IBA comes largely from primary care studies. Research in pharmacies, educational settings and criminal justice settings has indicated the possibilities for successful delivery of IBA but there is little solid evidence to support mainstreaming IBA beyond core medical facilities. Furthermore, even in primary health care settings there are continuing difficulties around implementing IBA (see: Thom et al., 2014) and continuing debate about the research findings (Heather, 2014). A number of key questions around the drive towards wider implementation of IBA were debated at an expert workshop in Birmingham in November 2014. The questions debated were: 1. What are the challenges and barriers to broadening the contexts in which alcohol IBA is delivered? 2. How can these challenges and barriers be addressed? 3. Should delivery of alcohol IBA in wider contexts (mainstreaming) be a policy goal? This monograph provides insights from this expert workshop and from the published literature on theses questions

Studies of the conformation of pyridine nucleotide coenzymes. 1 - Ord spectra and hypochromicity of NADH

Optical properties, fluorescence, and absorption spectra of reduced nicotinamide adenine dinucleotid

A continuous model for microtubule dynamics with catastrophe, rescue and nucleation processes

Microtubules are a major component of the cytoskeleton distinguished by highly dynamic behavior both in vitro and in vivo. We propose a general mathematical model that accounts for the growth, catastrophe, rescue and nucleation processes in the polymerization of microtubules from tubulin dimers. Our model is an extension of various mathematical models developed earlier formulated in order to capture and unify the various aspects of tubulin polymerization including the dynamic instability, growth of microtubules to saturation, time-localized periods of nucleation and depolymerization as well as synchronized oscillations exhibited by microtubules under various experimental conditions. Our model, while attempting to use a minimal number of adjustable parameters, covers a broad range of behaviors and has predictive features discussed in the paper. We have analyzed the resultant behaviors of the microtubules changing each of the parameter values at a time and observing the emergence of various dynamical regimes.Comment: 25 pages, 12 figure

Why Do Cascade Sizes Follow a Power-Law?

We introduce random directed acyclic graph and use it to model the information diffusion network. Subsequently, we analyze the cascade generation model (CGM) introduced by Leskovec et al. [19]. Until now only empirical studies of this model were done. In this paper, we present the first theoretical proof that the sizes of cascades generated by the CGM follow the power-law distribution, which is consistent with multiple empirical analysis of the large social networks. We compared the assumptions of our model with the Twitter social network and tested the goodness of approximation.Comment: 8 pages, 7 figures, accepted to WWW 201