9 research outputs found
Evaluation of temporomandibular disorders and oral health-related quality of life with obese patients
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
To what extent are the characteristics of painful temporomandibular disorders predictors of self-reported limitations in jaw function?
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Comparisons of measures that evaluate oral and general health quality of life in patients with temporomandibular disorder and chronic pain
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Evaluation of Arthrocentesis with and Without Platelet-Rich Plasma in the Management of Internal Derangement of Temporomandibular Joint: A Randomized Controlled Trial
- Author
- Akhilesh Kumar Singh
- BC Cooper
- CH Wilkes
- DW Nitzan
- E Anitua
- E Anitua
- E Kon
- E Schiffman
- F Cerza
- F Monje-Gil
- GJ Van Osch
- HR Lee
- J Fernandez-Sanroman
- J Lana
- JT Reston
- K Akeda
- L Guarda-Nardini
- M Barros-Vde
- M Ogren
- M Pihut
- Naresh Kumar Sharma
- Nitesh Mishra
- P. G. Naveen Kumar
- Rathindra Nath Bera
- RH Hossameldin
- Shreya Singh
- SL Lin
- WS Kirk Jr
- WS Pietrzak
- X Long
- X Xie
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dental Fluorosis Treatment Can Improve the Individuals’ OHRQoL? Results from a Randomized Clinical Trial
- Author
- Adulyanon S
- Akobeng AK
- Aoba T
- Azevedo MS
- Barros Vde M
- Bertassoni LE
- Bhagyajyothi CS
- Buck D
- Castro KS
- Chankanka O
- Cochran JA
- Cortes MI
- de Souza CF
- Denbesten P
- Flávio Fernando Demarco
- Fábio Correia Sampaio
- Garcia-Perez A
- Higashi C
- Kaline Silva Castro
- Kilpatrick NM
- Knösel M
- Li YJ
- Marilia LeĂŁo Goettems
- Meireles SS
- Meireles SS
- Meireles SS
- Moimaz SA
- Pontes DG
- Robinson PG
- Santa-Rosa TT
- Sischo L
- SĂ´nia Saeger Meireles
- Thylstrup A
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement
- Author
- A Møystad
- A Tsuruta
- Alaa Yasin
- American Dental Association
- B Sanders
- C Li
- C Poliotis
- D Manfredini
- D Manfredini
- D Manfredini
- E Kon
- E Machado
- EA Al-Moraissi
- Firas Taha Hamid
- Jafaar Nabeel
- JH Quinn
- K Lee
- L Guarda-Nardini
- LA Fortier
- M Barros-Vde
- M. Hadeel
- MJ Axe
- O Schierz
- PA Brennan
- PM Camargo
- R Emshoff
- R. Sammir
- R. Shwan
- Ra’ed M. Ayoub Al-Delayme
- RF Loeser
- S Sampson
- S Sampson
- Salah AbdulMahdy Ismaeel
- SF Dworkin
- Shahad Jamal Alfalahi
- Shefaa H. Alnuamy
- T Kondoh
- T Spakova
- Tariq Jassim Azzamily
- V Lekovic
- Ăś Voog
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Association between Tooth Loss and Degree of Temporomandibular Disorders: A Comparative Study
- Author
- Atsu SS Ayhan-Ardic F.
- Barros Vde M Seraidarian PI, Cortes MI, de Paula LV.
- Bordin TB Conci RA, Pezzini MM, Pezzini RP, Mendonca MJ.
- Da Fonseca DM Bonfante G, Valle AL, Freitas SFT.
- Dallanora AF Grasel CE, Heine CP, Demarco FF, Pereira-Cenci T, Presta AA, Boscato N.
- De Boever JA Carlsson GE, Klineberg IJ.
- Gui MS Rizzatti-Barbosa CM.
- Kohler AA Hugoson A, Magnusson T.
- Machado LP Nery Cde G, Leles CR, Nery MB, Okeson JP.
- Mercado MD Faulkner KD.
- Mollo Jr Francisco deA, Conti JV, Salvador MCG, Compagnoni MA, Nogueira SS.
- Motta LJ Guedes CC, De Santis TO, Fernandes KP, Mesquita-Ferrari RA, Bussadori SK.
- Okeson JP
- Papagianni CE van der Meulen MJ, Naeije M, Lobbezoo F.
- Resende CM Alves AC, Coelho LT, Alchieri JC, Roncalli AG, Barbosa GA.
- Ribeiro JA de Resende CM, Lopes AL, Farias-Neto A, Carreiro AD.
- Shibayama R Garcia AR, Zuim PRJ.
- Sipilä K Näpänkangas R, Könönen M, Alanen P, Suominen AL.
- Tallents RH Macher DJ, Kyrkanides S, Katzberg RW, Moss ME.
- Vanderas AP.
- Wang MQ Xue F, He JJ, Chen JH, Chen CS, Raustia A.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation
- Author
- A Gupta
- A Jayarangaiah
- A Nguyen
- A Porfidia
- A Rolandelli
- AB Pine
- AF Frade-Barros
- AK Maiti
- AM Batista
- AM Ierardi
- AP Lima
- AV Rapkiewicz
- B Chen
- B Cosmi
- BJ Carroll
- BK Manne
- BK Manne
- BT Bradley
- C de Roquetaillade
- C Venter
- CH Kim
- CH Ribeiro
- CJ Mycroft-West
- CM Ayo
- CR Bernardo
- D Barritault
- D Jacot
- D Modin
- DH Souza
- DS Marques
- E Del Nery
- E Dong
- E Gkogkou
- E Terpos
- EAN Azevedo
- EE Conners
- EE Ladikou
- F Gaertner
- F Taus
- F Zhou
- FL van de Veerdonk
- FMP van Haren
- FO Oliveira Jr
- FR Castillejos
- GD Barnes
- GP Lopes
- H Dou
- H Long
- I Hamming
- I Ibarra-Nava
- I Nimgaonkar
- I Paranjpe
- IH Chowdhury
- J Alonso-Padilla
- J Borawski
- J Samuel
- J Scharfstein
- J Scharfstein
- J Song
- J Szymanski
- J Zhu
- JA PĂ©rez-Molina
- JC Chang
- JE Kim
- JJ PuigbĂł
- JL Avila
- JM Connors
- K Hess
- LJ Ahrenfeldt
- LT Weckbach
- M Ackermann
- M Hoffmann
- M Ishihara
- M Iwasaki
- M Ming
- M Moreno
- M Quintanilla
- M Strauss
- M Strauss
- M Vlachou
- MA Ballinas-Verdugo
- MC Nunes
- ME Nizzoli
- MH Vaarala
- MI Wilde
- MJ Pinazo
- MJ Pinazo
- MK Smatti
- MND Di Minno
- MR Garvin
- MY Li
- N Beristain-Covarrubias
- N Beristain-Covarrubias
- O Eriksson
- OA Torres
- P Libby
- P Teixeira Vde
- P Thiagarajan
- PC Liaw
- PG Reis
- PS Sung
- R Bambino-Medeiros
- R Minix
- R Tandon
- RC Becker
- RM Alves
- RN Herrera
- S Esta
- S Oehmcke-Hecht
- S Spoto
- S Sze
- S Venturelli
- S Zhang
- SB Petkova
- T Menter
- T Yin
- V Cagno
- V Schmitz
- V Tiwari
- WH Mahallawi
- WK Ip
- Y Hou
- YC Kim
- Z Gao
- Z Varga
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Edoxaban versus warfarin in patients with atrial fibrillation
- Author
- Abdullakutty J
- Abi-Mansour P
- Abril SB
- Accini J
- Accini M
- Acikel M
- Acikel M
- Adachi C
- Adams K
- Adams K
- Adamus J
- Adler J
- Adler P
- Agarwal D
- Aggarwal R
- Aggarwal R
- Agirov M
- Agraou B
- Ahmad A
- Ahmadpour H
- Ahuad Guerrero R
- Ajioka M
- Akhter F
- Akihisa U
- Akilli H
- Al-Maliky T
- Al-Zoebi A
- Albert L. Waldo
- Albisu J
- Albulescu P
- Alexander J
- Alexandrova L
- Alexopoulos D
- Alexopoulos D
- Alhakim M
- Aliyar P
- Allall O
- Allison J
- Allman J
- Almaraz SP
- Almeida A
- Almeida M
- Almquist A
- Aloni I
- Alsheikh T
- Altonen D
- Alvarez C
- Alvarez M
- Alvarez RF
- Amarenco P
- Amato Vincenzo de Paola A
- Ambrovic I
- Ambrovicova V
- Ameriso P
- Ameriso S
- Amin K
- Amin M
- Amuchastegui M
- Anciu M
- Anderson C
- Anderson J
- Anderson J
- Andersson R
- Andor M
- Andrade Lotufo P
- Andresen T
- Andrews A
- Angel J
- Anscombe R
- Anthony A
- Antle S
- Antman EM
- Antman EM
- Antonino M
- Anzai T
- Apetrei E
- Apostolovic S
- Appelros P
- Aquino M
- Arakawa S
- AraĂşjo E
- Archibald J
- Arcocha Torres M
- Ardelean A
- Arfaoui M
- Arias J
- Armas BH
- Arneja J
- Arnold T
- Arora T
- Arora V
- Arouni A
- Arrieta M
- Arroyave C
- Arstall M
- Arutyunov G
- Asakura H
- Asensio A
- Astier L
- Ata N
- Ata N
- Atar D
- Atar D
- Atar S
- Atie J
- Atkinson C
- Attanti S
- Aude Y
- Augusto Alves da Costa F
- Aull L
- Ault S
- Ausperger KM
- Avellar K
- Averett P
- Avery D
- Avila H
- Avvaru G
- Awasty V
- Awtry E
- Ayasse D
- Ayau Milla O
- Ayesu K
- Aylward P
- Azhdari M
- Azua MG
- Babbar A
- Babbolin M
- Babilonia N
- Babilonia N
- Babu P
- Babu R
- Babuty D
- Badenhorst J
- Badila E
- Bae HJ
- Bagatin J
- Bagby J
- Bai F
- Baine S
- Bakliza Z
- Balboa W
- Baldwin E
- Ball E
- Ballyuzek M
- Baman R
- Bamhorst M
- Bamrungpong P
- Banaeian F
- Banikova A
- Banikova A
- Banker D
- Bansal N
- Banville P
- Bar M
- Barai A
- Baranyai M
- Barash B
- Barbarash O
- Barber M
- Barbera S
- Barcinas R
- Barker T
- Barnhorst M
- Barquero R
- Barrington P
- Barros R
- Barroso D
- Bart B
- Bartholomaus D
- Bartkowiak A
- Bartos D
- Bashkireva A
- Basson M
- Baszak J
- Baszak J
- Batchell K
- Batista M
- Batta C
- Battistelli E
- Batushkin V
- Bauch F
- Bauch F
- Bauer K
- Bautista C
- Bayata S
- Bayata S
- Baylacher M
- Bayram Llamas E
- Bazylevych A
- Beasley R
- Beck P
- Bedenko E
- Bedoya R
- Bedregal SA
- Bedwell N
- Beerts C
- Beeton I
- Behm K
- Beinart S
- Bekal S
- Belatsky V
- Belcuore M
- Belenky D
- Belhassane A
- Beloscar J
- Belousova L
- Ben Ari M
- Benatar J
- Bengtsson AS
- Bengus C
- Benicka E
- Benjarge P
- Bensimhon D
- Bentivenga L
- Benton J
- Berbari H
- Berbari H
- Bereznyakov I
- Berger CJ
- Berger N
- Bergovec M
- Bergovec M
- Berk M
- Berka L
- Berli M
- Berli M
- Bernard J
- Bernhardt P
- Berni A
- Berns S
- Berrouschot J
- Bertolim Precoma D
- Betcher J
- Beyer-Westendorf J
- Bharani A
- Bhargava R
- Bhargava V
- Bhaskarwar P
- Bhuti M
- Bianchini M
- Bilal B
- Bilazarian S
- Bingham S
- Biniek D
- Biniwale A
- Binns M
- Biscardi R
- Bjelobrk M
- Blagden M
- Blanc J
- Blanc JJ
- Blanco Coronado J
- Blihar O
- Block T
- Blom KB
- Blomström P
- Blonder R
- Bloomberg K
- Bloomberg R
- Blue B
- Bobade M
- Bobbie C
- Bobescu E
- Bocanera M
- Bognar A
- Bojanowska E
- Bokarev I
- Bollova D
- Bolohan F
- Bolohan F
- Bolton R
- Bonds C
- Bonin K
- Bonora M
- Boriani G
- Borowski W
- Borsheim M
- Borthwick L
- Bosco B
- Bose S
- Bossaers J
- Botelho R
- Botero R
- Botha L
- Bouchard A
- Bourlios P
- Boursin P
- Bouzo M
- Bowden W
- Bowen L
- Bowman B
- Boyer M
- Bozek B
- Bradley A
- Braemer U
- Braun D
- Braun R
- Braunwald E
- Braunwald E
- Breschi M
- Bridge C
- Brilakis E
- Briscoe C
- Broberg M
- Brodova P
- Brondani R
- Bronisz M
- Brown F
- Brown H
- Brown R
- Browning J
- Brtko M
- Brtko M
- Brubaker S
- Bruguera Cortada J
- Bruning T
- Bruton T
- Buchholz M
- Budassi N
- Buelow-Johansen B
- Bugueño C
- Buhler A
- Buhr M
- Buiks C
- Buiks C
- Builes A
- Buksa B
- Bulgari M
- Bulygin S
- Burianova H
- Burianova H
- Bush D
- Bustamante G
- Bustamante Labarta G
- Busz-Papiez B
- Butcher S
- Buza V
- Buzzetti C
- Bybee K
- Cabero P
- Cabrera J
- Caccavo A
- Caceres M
- Cader C
- Cajulis C
- Cakmak N
- Calambur N
- Calderon M
- Calik A
- Calvo C
- Calvo G
- Calvo M
- Calvo Vargas C
- Camm J
- Camm J
- Cammell R
- Campbell G
- Campisto Y
- Canaday D
- Cannoni S
- Cano N
- Canosa R
- Capasso-Gulve E
- Capiau L
- Caplan J
- Car S
- Cardona Muñoz E
- Cardoza T
- Carevic V
- Carey G
- Carey J
- Carlsson T
- Carne M
- Carr K
- Carraro A
- Carrasco GT
- Carrillo J
- Carrion A
- Carroll L
- Cartasegna L
- Caruso O
- Casares E
- Casas R
- Castro C
- Caterini T
- Cavanna L
- Cayli M
- Cayli M
- Ceirano C
- Celic V
- Cemerlic Adjic N
- Cendali G
- Cermak O
- Cermak O
- Cervellione K
- Cervi E
- Ceyhan C
- Ceyhan C
- Cha J
- Cha JK
- Cha MJ
- Chacon L
- Champagne M
- Chang M
- Chapman O
- Charlat M
- Chaturvedi S
- Chaves Junior H
- Chavez C
- Chehayeb R
- Chen JZ
- Chen SA
- Chen XP
- Chen YF
- Chen YP
- Chendey T
- Cheng CC
- Cheng CC
- Chernyavskaya T
- Cherrico M
- Chiang CE
- Chiang FT
- Chilvers M
- Chiou CW
- Chiu CZ
- Chmielowski A
- Cho BR
- Choi HH
- Choi KJ
- Choi Y
- Chompalova B
- Chopda M
- Choy A
- Christensen H
- Christensen L
- Christian T. Ruff
- Chumakova G
- Chun MY
- Chung A
- Chung N
- Chung WS
- Ciaramita J
- Cieslak B
- Ciezak P
- Ciglenecki N
- Ciobotaru G
- Ciortea M
- Clapp T
- Claussen H
- Clay A
- Cleveland D
- Clifton R
- Clinckemaille N
- Cobos D
- Cobos J
- Coching R
- Codutti O
- Cohen A
- Cohen A
- Cohen R
- Coisne D
- Colan D
- Cole J
- Colin MA
- Colombo H
- Colquhoun D
- Coman I
- Comi G
- Concha M
- Connolly S
- Constance C
- Constantinescu M
- Constantinescu M
- Contzen C
- Cook S
- Coombs V
- Copley M
- Corbalan R
- Corbalán R
- Corbett B
- Corbut S
- Corchado D
- Correia J
- Correia J
- Cossu S
- Costache L
- Costantini C
- Costi P
- Cottiero R
- Coutinho E
- Coutu B
- Cowan L
- Cox C
- Coyle GS
- Cozma M
- Craft D
- Craig M
- Crerand W
- Creteanu M
- Crimmins D
- Cristaldi J
- Cristea M
- Crisu D
- Croce K
- Cuccia C
- Cuello J
- Cullen T
- Cuneo C
- Cunha S
- Curt V
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- Cury C
- Cush S
- Cymerman K
- Cymerman K
- Cásares Ramirez M
- D'Amico A
- D'Costa D
- D'Souza A
- Dabrowska M
- Dagan T
- Daitz C
- Dalby A
- Dalby A
- Dandekar U
- Dang N
- Daniels R
- Daniels S
- Dart A
- Daskalaki A
- Dastoli K
- Datta S
- Daut W
- Dave B
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- Davicevic Z
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- Davies D
- Davis A
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- Davolos M
- Davuluri A
- Davé J
- de Arce Borda A
- De Bleecker J
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- De Caterina R
- de Groot J
- de Koning K
- de la Mora S
- De Lemos J
- de Melo RF
- De Pace D
- De Patta M
- De Servi S
- De Tollenaere M
- de Vos R
- de Vos R
- Dean J
- Debes C
- Decoulx E
- Deenadayalu N
- DeGarmo R
- Degtyareva E
- Delgadillo T
- Delgado A
- Delgado MD
- Delgado P
- Delgado Restrepo J
- Delgado S
- Demir H
- Demir H
- Demko A
- Denchev S
- Denie D
- Denis I
- Dennison K
- Deokar M
- Derlaga B
- Deruche E
- Derycker K
- Desai A
- Desai A
- DeSalle D
- Desfontaines P
- Desire A
- Despotovic N
- Dettmann S
- Devenport S
- Dewar C
- Dhar S
- Dharmarao A
- Di Lenarda A
- Di Niro M
- Di Pasquale G
- Dias P
- Diaz IA
- Diaz PA
- Diaz-Pintado M
- Dichristin U
- Dicker D
- Dickinson D
- Dickinson D
- DiCorcia L
- Dieckheuer U
- Diez Tejedor E
- DiGiovanna M
- Dimitra K
- Dinanian S
- Dioszeghy P
- Djokic I
- Djokovic A
- Djordjevic-Radojkovic D
- do Val R
- Dobre I
- Dobreanu D
- Doctor A
- Dodt K
- Doka B
- Domanska E
- Domingo D
- Donahue S
- Dong YG
- Dongas B
- Donova T
- Donovan D
- Dorn S
- Dorobantu M
- Dotani I
- Dotsenko S
- Dougal K
- Doughty R
- Douglas H
- Douglas S
- Dovgalevsky P
- Dovgan N
- Dowling C
- Dragomir D
- Dran R
- Drapchak I
- Drapkina O
- Drescher T
- Drew B
- Dreykluft K
- Dronov D
- Drozdiak R
- du Preez M
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- Duff J
- Dufresne M
- Dugal J
- Duggal A
- Dukat A
- Duki Y
- Dulka T
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- Duncan D
- Dunn K
- Dunn S
- Duprat C
- Duris T
- Duris T
- Dutka C
- Dutra O
- Dutter S
- Dvoieglazova M
- Dzublik Y
- Dzupina A
- Dzupinova M
- Dzyak G
- Eade J
- Easton JD
- Ebano P
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- Ebert J
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- Edelstein J
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- Eikelboom J
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- Eldadah Z
- Eldred R
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- Elliott M. Antman
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- Engelbrecht J
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- Ensminger E
- Erasmus L
- Erceg P
- Erdogan D
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- Eriksson G
- Ermis C
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- Erofeeva S
- Esip V
- Essop M
- Estol C
- Ettinger N
- Eugene Braunwald
- Everhart B
- Ewing B
- Exarchou E
- Ezekowitz M
- Facello A
- Facello M
- Faghih M
- Faghih M
- Fahmy R
- Faircloth C
- Falu E
- Fattore L
- Faucett S
- Faustino Saporito W
- Faynyk A
- Fedacko J
- Fedotov S
- Feil JF
- Fekete A
- Feld L
- Feldman J
- Felsman D
- Felten W
- Femenia F
- Feng C
- Fenu L
- Ferguson D
- Ferkl R
- Ferkl R
- Fernandez E
- Fernandez M
- Fernández Ruiz R
- Ferraz RF
- Ferreira L
- Ferri Certic J
- Fialkow J
- Filatov A
- Finimundi H
- Fink P
- Finkel M
- Finkelstein S
- Finlayson M
- Finsterbusch T
- Fiok J
- Fischell T
- Fishbein G
- Fisher M
- Fisher M
- Fisher M
- Fisher M
- Fisher R
- Fleck N
- Flecknoe-Brown S
- Fleets J
- Flint L
- Florenzano F
- Flores E
- Florian J
- Florian J
- Fonseca J
- Forck-Boedeker K
- Forgione C
- Forman S
- Formoso I
- Fortin C
- Foster B
- Fracaro V
- Frahm E
- Frais M
- Francalacci G
- Francek L
- Francek L
- Francetic I
- Francis A
- Francis J
- Francis V
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- Franco M
- Freeman R
- Freemyer D
- French W
- Frey W
- Friedlander I
- Frommhold R
- Frost J
- Fu GS
- Fuchs R
- Fujii E
- Fujii K
- Fujii R
- Fujimoto C
- Fujimoto E
- Fujimoto K
- Fujimoto S
- Fujita T
- Fujiwara M
- Fujiwara Y
- Fukamizu S
- Fuki Y
- Fukuda N
- Funazaki T
- Funes I
- Furiozzi F
- Furukawa Y
- Fuselli J
- Gabela W
- Gadepalli R
- Gaffney M
- Gaggioli G
- Gagliano M
- Gagliardi R
- Gamachek O
- Gandur H
- Gani M
- Gant Lopez J
- Gao M
- Garb J
- Garcia Duran R
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- Garcia M
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- Garcia-Castillo A
- GarcĂa-Castillo A
- Garman V
- Garner S
- Garrido M
- Garza M
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- Zamlynskyy M
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- Zateyshchikov D
- Zateyshchikova A
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- Zharinov O
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- Zubeeva G
- Zyatenkova E
- Ă…kerberg A
- Ă–stberg S
- Ĺśpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)