Constitutionally Recognizing Court Mandated Arbitration: Paradise Found or Problems Abound - Firelock Inc. v. District Court

This Note will argue that notwithstanding any criticism of the court-annexed arbitration procedure, the Colorado Supreme Court is taking a leadership position in upholding and expanding the role for arbitration, by recognizing that this form of alternative dispute resolution is less expensive, saves judicial time, provides for confidentially, and most importantly, provides the parties with a sense of fairness in the outcome

The flexibility of virtual energy storage based on the thermal inertia of buildings in renewable energy communities: A techno-economic analysis and comparison with the electric battery solution

The Renewable Energy Community (REC) concept has been introduced into the European decarbonization guidelines to promote the utilization of Renewable Energy Sources (RES) and to incentivize their self-consumption at the local level. This paper analyzes the flexible use of Heat Pumps (HP) for building heating in an REC context. The Power-to-Heat (P2H) energy conversion process of HP allows the flexibility of the thermal sector to be exploited within the electricity sector: in this way, it is possible to store energy in the form of heat inside the building mass and then use the stored energy to reduce the building heating demand in the hours following the accumulation of energy. This energy storage solution has been defined as building-based Virtual Energy Storage (VES). The flexibility enabled by VES has been used to optimize the self-consumption of an REC. The flexible VES solution was evaluated, from a technical and economic point of view, through a sensitivity analysis on the variation of the RES penetration, and the results were compared with those based on a more traditional centralized electric battery (EB) storage system. The results demonstrated that the VES solution is less flexible than electric batteries. Nevertheless, both flexible solutions (VES and EB) can significantly increase the REC self-consumption: the self-consumed energy increased by between 6% and 44% thanks to the exploitation of the VES flexibility, while the EB flexibility enabled an increase in the self-consumed energy of 19% to 63% according to the scenario analyzed. However, due to the high investment cost of EB, the VES configuration resulted to be the best solution from an economic point of view

Pengaruh Indol-3-butiric-acid Dan Thidiazuron Terhadap Multiplikasi Tunas Nenas (Ananas Comosus (L) Merr) CV. Smooth Cayyene Secara in Vitro

Pineapple (Ananas comosus L.) is one of the most potential fruit crop cultivating in Indonesia. However, it is difficult to meet the demand for planting materials using the conventional propagation techniques due to production inefficiency. This research aim to know the influence solid medium of Murashige and Skoog (MS) composed of Indol-3-Butiric Acid and Thidiazuron, upon pineapple Var Smooth Cayenne shoot multiplication response. Shoot multiplication using a factorial complete random design. The first is a 3-level IBA concentration (0.3 ppm, 0.6 ppm, 0.9 ppm), a 3-level TDZ concentration (0.2 ppm, 0.4 ppm, 0.6 ppm). The finding shows that MS richly composed IBA and TDZ with low concentration gives 100% shoot the fastest periodic appearance (two weeks after incubation). Varians analysis finding shows that there is no interaction between IBA and TDZ.Low IBA concentration gives the higest quantity of shoot 9.32 (5.60 data transformation) at 5 week after incubation, at the end of the analysis tends to give the higest shoot 11.17 (6.18 data transformation) even though it is statistically not slighty difference. The highest TDZ concentration (0,6 ppm) give a few number of roots 0.89 (2,65 data transformation) and the lowes shoots leaf 3.84 (4.04 data transformation). The higher the TDZ is, the more nodal may appear

Demand flexibility enabled by virtual energy storage to improve renewable energy penetration

The increasing resort to renewable energy distributed generation, which is needed to mitigate anthropogenic CO2 emissions, leads to challenges concerning the proper operation of electric distribution systems. As a result of the intrinsic nature of Renewable Energy Sources (RESs), this generation shows a high volatility and a low predictability that make the balancing of energy production and consumption difficult. At the same time, the electrification of new energy‐intensive sectors (such as heating) is expected. This complex scenario paves the way for new sources of flexibility that will have more and more relevance in the coming years. This paper analyses how the electrification of the heating system, combined with an electric flexibility utilisation module, can be used to mitigate the problems related to the fluctuating production of RES. By using Power‐to‐Heat (P2H) technologies, buildings are able to store the overproduction of RES in the form of thermal energy for end‐use according to the principle of the so‐called Virtual Energy Storage (VES). A context‐aware demand flexibility extraction based on the VES model and the flexibility upscale and utilisation on district‐level through grid simulation and energy flow optimisation is presented in the paper. The involved modules have been developed within the PLANET (PLAnning and operational tools for optimising energy flows and synergies between energy NETworks) H2020 European project and interact under a unified co‐simulation framework with the PLANET Decision Support System (DSS) for the analysis of multi‐energy scenarios. DSS has been used to simulate a realistic future energy scenario, according to which the imbalance problems triggered by RES overproduction are mitigated with the optimal exploitation of the demand flexibility enabled by VES

Co-simulation Management Algorithm for Distribution System Operation with Real-Time Simulator

This article presents a co-simulation framework consistent with the real-time simulation for operational analysis of electrical distribution networks. Realtime simulators have become a fundamental tool for testing and optimising control strategies in a safe and controlled environment. The proposed methodology outlines the steps required for setting up, controlling, and monitoring an electrical grid using a real-time simulator. The framework proposes the use of the Message Queuing Telemetry Transport communication between the electrical grid module and an external coordinator. An algorithm based on the Python programming language is proposed to manage the real-time simulation, create the grid topology, and communicate with the external coordinator. The implementation of the electrical network and the validation of the real-time simulator network are also presented. The article concludes that the proposed framework can improve the performance and flexibility of co-simulation for studies on the penetration of power electronics-based renewable sources

Correction: Shekarkar Azgomi et al. A Rapid and Simple Multiparameter Assay to Quantify Spike-Specific CD4 and CD8 T Cells after SARS-CoV-2 Vaccination: A Preliminary Report

In the original publication, there was a mistake in Figure 1A, as published [1]. A FACS plot for IL-2 production was duplicated during the editing of the Figure through mere error, between non-stimulated and stimulated conditions. In detail, we duplicated the sixth plot of the upper row from the third plot of the middle row. The corrected Figure 1 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated

Quantification of transient increase of the blood–brain barrier permeability to macromolecules by optimized focused ultrasound combined with microbubbles

Radioimmunotherapy using a radiolabeled monoclonal antibody that targets tumor cells has been shown to be efficient for the treatment of many malignant cancers, with reduced side effects. However, the blood–brain barrier (BBB) inhibits the transport of intravenous antibodies to tumors in the brain. Recent studies have demonstrated that focused ultrasound (FUS) combined with microbubbles (MBs) is a promising method to transiently disrupt the BBB for the drug delivery to the central nervous system. To find the optimal FUS and MBs that can induce reversible increase in the BBB permeability, we employed minimally invasive multiphoton microscopy to quantify the BBB permeability to dextran-155 kDa with similar molecular weight to an antibody by applying different doses of FUS in the presence of MBs with an optimal size and concentration. The cerebral microcirculation was observed through a section of frontoparietal bone thinned with a micro-grinder. About 5 minutes after applying the FUS on the thinned skull in the presence of MBs for 1 minute, TRITC (tetramethylrhodamine isothiocyanate)-dextran-155 kDa in 1% bovine serum albumin in mammalian Ringer’s solution was injected into the cerebral circulation via the ipsilateral carotid artery by a syringe pump. Simultaneously, the temporal images were collected from the brain parenchyma ~100–200 μm below the pia mater. Permeability was determined from the rate of tissue solute accumulation around individual microvessels. After several trials, we found the optimal dose of FUS. At the optimal dose, permeability increased by ~14-fold after 5 minutes post-FUS, and permeability returned to the control level after 25 minutes. FUS without MBs or MBs injected without FUS did not change the permeability. Our method provides an accurate in vivo assessment for the transient BBB permeability change under the treatment of FUS. The optimal FUS dose found for the reversible BBB permeability increase without BBB disruption is reliable and can be applied to future clinical trials

Graphene Photonics and Optoelectronics

The richness of optical and electronic properties of graphene attracts enormous interest. Graphene has high mobility and optical transparency, in addition to flexibility, robustness and environmental stability. So far, the main focus has been on fundamental physics and electronic devices. However, we believe its true potential to be in photonics and optoelectronics, where the combination of its unique optical and electronic properties can be fully exploited, even in the absence of a bandgap, and the linear dispersion of the Dirac electrons enables ultra-wide-band tunability. The rise of graphene in photonics and optoelectronics is shown by several recent results, ranging from solar cells and light emitting devices, to touch screens, photodetectors and ultrafast lasers. Here we review the state of the art in this emerging field.Comment: Review Nature Photonics, in pres