Adaptive feedback analysis and control of programmable stimuli for assessment of cerebrovascular function

The assessment of cerebrovascular regulatory mechanisms often requires flexibly controlled and precisely timed changes in arterial blood pressure (ABP) and/or inspired CO2. In this study, a new system for inducing variations in mean ABP was designed, implemented and tested using programmable sequences and programmable controls to induce pressure changes through bilateral thigh cuffs. The system is also integrated with a computer-controlled switch to select air or a CO2/air mixture to be provided via a face mask. Adaptive feedback control of a pressure generator was required to meet stringent specifications for fast changes, and accuracy in timing and pressure levels applied by the thigh cuffs. The implemented system consists of a PC-based signal analysis/control unit, a pressure control unit and a CO2/air control unit. Initial evaluations were carried out to compare the cuff pressure control performances between adaptive and non-adaptive control configurations. Results show that the adaptive control method can reduce the mean error in sustaining target pressure by 99.57 % and reduce the transient time in pressure increases by 45.21 %. The system has proven a highly effective tool in ongoing research on brain blood flow control

Detection of impaired cerebral autoregulation improves by increasing arterial blood pressure variability

Although the assessment of dynamic cerebral autoregulation (CA) based on measurements of spontaneous fluctuations in arterial blood pressure (ABP) and cerebral blood flow (CBF) is a convenient and much used method, there remains uncertainty about its reliability. We tested the effects of increasing ABP variability, provoked by a modification of the thigh cuff method, on the ability of the autoregulation index to discriminate between normal and impaired CA, using hypercapnia as a surrogate for dynamic CA impairment. In 30 healthy volunteers, ABP (Finapres) and CBF velocity (CBFV, transcranial Doppler) were recorded at rest and during 5% CO(2) breathing, with and without pseudo-random sequence inflation and deflation of bilateral thigh cuffs. The application of thigh cuffs increased ABP and CBFV variabilities and was not associated with a distortion of the CBFV step response estimates for both normocapnic and hypercapnic conditions (P=0.59 and P=0.96, respectively). Sensitivity and specificity of CA impairment detection were improved with the thigh cuff method, with the area under the receiver-operator curve increasing from 0.746 to 0.859 (P=0.031). We conclude that the new method is a safe, efficient, and appealing alternative to currently existing assessment methods for the investigation of the status of CA

Extensive infrared spectroscopic study of CuO: signatures of strong spin-phonon interaction and structural distortion

Optical properties of single-crystal monoclinic CuO in the range 70 - 6000 \cm were studied at temperatures from 7 to 300 K. Normal reflection spectra were obtained from the (001) and (010) crystal faces thus giving for the first time separate data for the $A_{u}$ and $B_{u}$ phonon modes excited in the purely transverse way (TO modes). Mode parameters, including polarizations of the $B_{u}$ modes not determined by the crystal symmetry, were extracted by the dispersion analysis of reflectivity curves as a function of temperature. Spectra of all the components of the optical conductivity tensor were obtained using the Kramers-Kronig method recently extended to the case of the low-symmetry crystals. The number of strong phonon modes is in agreement with the factor-group analysis for the crystal structure, currently accepted for the CuO. However, several "extra" modes of minor intensity are detected. Comparison of frequencies of "extra" modes with the available phonon dispersion curves points to possible "diagonal" doubling of the unit cell \{{\bf a}, {\bf b}, {\bf c}\} $\to$ \{{\bf a}+{\bf c}, {\bf b}, {\bf a}-{\bf c}\} and formation of the superlattice. The previously reported softening of the $A^{3}_{u}$ mode ($\sim$ 400 \cm) with cooling at $T_{N}$ is found to be $\sim$ 10 % for the TO mode. The mode is very broad at high temperatures and strongly narrows in the AFM phase. We attribute this effect to strong resonance coupling of this mode to optical or acoustic bi-magnons and reconstruction of the magnetic excitations spectrum at the N\'eel point. A significant anisotropy of $\epsilon^{\infty}$ is observed: it was found to be 5.9 along the {\bf b}-axis, 6.2 along the {[}101{]} chains and 7.8 the {[}10$\bar{1}${]} chains. The "transverse" effective charge is value is about 2 electrons.Comment: 23 pages, 14 figures, REVTeX, submitted to PR

B-T phase diagram of CoCr2O4 in magnetic fields up to 14 T

We have measured the magnetization and specific heat of multiferroic CoCr2O4 in magnetic fields up to 14 T. The high-field magnetization measurements indicate a new phase transition at T* = 5 - 6 K. The phase between T* and the lock-in transition at 15 K is characterized by magnetic irreversibility. At higher magnetic fields, the irreversibility increases. Specific-heat measurements confirm the transition at T*, and also show irreversible behavior. We construct a field-temperature phase diagram of CoCr2O4.Comment: 4 page

Effects of Avoparcin on Performance of Feedlot Heifers

Avoparcin is a glycopeptide antibiotic produced by a strain of streptomyces candidus with activity against certain gram positive organisms. It has been reported to reduce the ratio of acetate to propionate produced during rumen fermentation and to improve weight gain and feed efficiency of feedlot cattle. This study was conducted to evaluate the effects of 30, 45 and 60 grams per ton of avoparcin and 30 grams per ton of monensin in the feed on weight gain, feed utilization and carcass quality of finishing heifers over a 140-day feeding period

Vitamin A Bioptency as Measured by Stores of Vitamin A in Livers of Feedlot Cattle

The objective of these experiments was to evaluate the biological potency of two sources of vitamin A premix differing in freshness when administered to fattening beef cattle. Chemical assays were compared with blood and liver vitamin A content to measure the biopotency of the vitamin

Longitudinal Match Performance Characteristics of UK and Non-UK Players in the English Premier League

This study investigated the longitudinal match performance characteristics in the English Premier League (EPL), with special reference to player nationality (UK vs. non-UK). Match observations (n = 14700) were collected using a multi-camera computerised tracking system across 7 consecutive EPL seasons (2006–2007 to 2012– 2013). Player nationality referred to their birthplace, with players born in England, Scotland, Wales or Northern Ireland classified as the UK players and other nationalities considered non-UK. The non-UK players demon- strated the most pronounced increases in high-intensity running distance across the 7 seasons compared with UK players (P 0.05, ES: 0.08 [CI 0.01–0.15]). In contrast, the non-UK players performed more passes in 2006–2007 compared with the UK players (P 0.05, ES: 0.05 [CI −0.01–0.13]). The data demonstrates that the longitudinal match performance characteristics in the EPL are similar between the UK and non-UK populations

Evolution of match performance parameters for various playing positions in the English Premier League

This study aimed to investigate position-specific evolution of physical and technical performance parameters in the English Premier League (EPL). Match performance observations (n = 14700) were collected using a multiple-camera computerized tracking system across seven seasons (2006–07 to 2012–13). Data were analyzed relative to five playing positions: central defenders (n = 3792), full backs (n = 3420), central midfielders (n = 3200), wide midfielders (n = 2136) and attackers (n = 2152). High-intensity running distance increased in the final season versus the first season in all playing positions (p < .05, ES: 0.9–1.3) with full backs displaying the greatest increase (∼36% higher in 2012–13). Similar trends were observed for sprint distance with full backs demonstrating the most pronounced increase across the seven seasons (36–63%, p < .001, ES: 0.8–1.3). Central players (central defenders and midfielders) illustrated the most pronounced increases in total passes and pass success rate (p < .05, ES: 0.7–0.9) whilst wide players (full backs and wide midfielders) demonstrated only small-moderate increases in total passes and pass success rate (p < .05, ES: 0.6–0.8). The data demonstrates that evolving tactics in the EPL have impacted on the physical demands of wide players and the technical requirements of central players. These findings could be used for talent identification or position-specific physical and technical training