Rancang Bangun E-Library pada SMAN 1 Pagerbarang Tegal

Teknologi informasi merupakan salah satu hal penting pada era globalisasi saat ini. Perkembangan imu teknologi dan pengetahuan selalu memicu manusia untuk berkembang dan bersaing dalam pengusaan teknologi khususnya teknologi informasi dan komputer. Salah satunya internet, internet dapat memberikan kemudahan mencari informasi di segala aspek. Perkembangan ilmu teknologi berpengaruh pada dunia pendidikan. Banyak lembaga pendidikan yang memanfaatkan teknologi internet untuk memberikan informasi kepada masyarakat. Sistem infomasi perpustakaan merupakan suatu sistem yang memudahkan user untuk mencari informasi dengan menggunakan jaringan internet. Mempermudah dalam menyimpan data dan mengolah data dengan cepat dan tepat tanpa membutuhkan waktu lama dalam proses pengerjaannya. Melihat Kenyataan diatas, penulis membuat program sistem informasi e-library yang ditunjukan pada “SMA N 1 Pagerbarang, Tegal”. Bertujuan untuk mempermudah pelayanan perpustakaan dan mempermudah siswa mendapatkan buku referensi dan mata pelajaran. Siswa juga dipermudah untuk mencari informasi tentang artikel yang ada pada website e-library. Perancangan program e-library ini dibuat menggunakan Adobe Dreamweaver CS6, php dan mysql. Program ini dibuat untuk mempermudah siswa mendapatkan e-book tanpa harus datang ke perpustakaan. Dan mempermudah pegawai perpustakaan untuk mengolah data yang sudah ada. Program ini dibuat untuk memecahkan masalah yang ada seperti kendala waktu dan tempat. Dengan adanya program ini maka kegiatan akan lebih efektif dan efisien

The Level of Inclusion of Transitional Services Competencies in Special Education Programs in Saudi Universities

The study aimed to identify the level of inclusion of transitional services competencies in special education programs in Saudi universities from the point of view of faculty members. In addition to studying the differences between the responses of faculty members according to the variables: the date of establishing the program, the number of courses related to transitional services, and the availability of specialists in this field. The sample consisted of 164 faculty members in special education programs in 22 Saudi universities. Results indicated that the inclusion of transitional services competencies in the special education programs in Saudi universities came to a moderate degree. Moreover, these competencies are more included in older established special education programs, programs with more courses related to transitional services, and programs that have specialists in this field. Finally, the results included some recommendations to improve the inclusion of competencies in special education programs in those universities. Keywords: Competencies of pre-service teachers, Transitional Services, Special Education Programs

Proteoglycan-4 Regulates Fibroblast to Myofibroblast Transition and Expression of Fibrotic Genes in the Synovium

Background: Synovial tissue fibrosis is common in advanced OA with features including the presence of stress fiber-positive myofibroblasts and deposition of cross-linked collagen type-I. Proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and is a major component of synovial fluid. PRG4 is a ligand of the CD44 receptor. Our objective was to examine the role of PRG4-CD44 interaction in regulating synovial tissue fibrosis in vitro and in vivo. Methods: OA synoviocytes were treated with TGF-β ± PRG4 for 24h and α-SMA content was determined using immunofluorescence. Rhodamine-labeled rhPRG4 was incubated with OA synoviocytes ± anti-CD44 or isotype control antibodies and cellular uptake of rhPRG4 was determined following a 30-min incubation and α-SMA expression following a 24-h incubation. HEK-TGF-β cells were treated with TGF-β ± rhPRG4 and Smad3 phosphorylation was determined using immunofluorescence and TGF-β/Smad pathway activation was determined colorimetrically. We probed for stress fibers and focal adhesions (FAs) in TGF-β-treated murine fibroblasts and fibroblast migration was quantified ± rhPRG4. Synovial expression of fibrotic markers: α-SMA, collagen type-I, and PLOD2 in Prg4 gene-trap (Prg4GT) and recombined Prg4GTR animals were studied at 2 and 9 months of age. Synovial expression of α-SMA and PLOD2 was determined in 2-month-old Prg4GT/GT&Cd44−/− and Prg4GTR/GTR&Cd44−/− animals. Results: PRG4 reduced α-SMA content in OA synoviocytes (p \u3c 0.001). rhPRG4 was internalized by OA synoviocytes via CD44 and CD44 neutralization attenuated rhPRG4’s antifibrotic effect (p \u3c 0.05). rhPRG4 reduced pSmad3 signal in HEKTGF- β cells (p \u3c 0.001) and TGF-β/Smad pathway activation (p \u3c 0.001). rhPRG4 reduced the number of stress fiberpositive myofibroblasts, FAs mean size, and cell migration in TGF-β-treated NIH3T3 fibroblasts (p \u3c 0.05). rhPRG4 inhibited fibroblast migration in a macrophage and fibroblast co-culture model without altering active or total TGF-β levels. Synovial tissues of 9-month-old Prg4GT/GT animals had higher α-SMA, collagen type-I, and PLOD2 (p \u3c 0.001) content and Prg4 re-expression reduced these markers (p \u3c 0.01). Prg4 re-expression also reduced α-SMA and PLOD2 staining in CD44-deficient mice. Conclusion: PRG4 is an endogenous antifibrotic modulator in the joint and its effect on myofibroblast formation is partially mediated by CD44, but CD44 is not required to demonstrate an antifibrotic effect in vivo

Evaluation of off-service rotations at National Guard Health Affairs: Results from a perception survey of off-service residents

Context: "Off-service" clinical rotations are part of the necessary requirements for many residency training programs. Because these rotations are off-service, little attention is given to their structure and quality of training. This often leads to suboptimal educational experience for the residents on these rotations. Aims: The aim of this study was to assess medical residents′ perceptions, opinions, and levels of satisfaction with their "off-service" rotations at a major residency training site in Saudi Arabia. It was also to evaluate the reliability and validity of a questionnaire used for quality assurance in these rotations. Improved reliability and validity of this questionnaire may help to improve the educational experience of residents in their "off-service" rotations. Materials and Methods: A close-ended questionnaire was developed, Pilot tested and distributed to 110 off-service residents in training programs of different specializations at King Fahad Naitonal Guard Hospital and King Abdulziz Medical City, Riyadh, Saudi Arabia, between September 2011 and December 2011. Results: A total of 80 out of 110 residents completed and returned the questionnaire. Only 33% of these residents had a clear set of goals and educational learning objectives before the beginning of their off-service rotations to direct their training. Surgical specializations had low satisfaction mean scores of 57.2 (11.9) compared to emergency medicine, which had 70.7 (16.2), P value (0.03). The reliability of the questionnaire was Cronbach′s alpha 0.57. The factor analysis yielded a 4-factor solution (educational environment, educational balance, educational goals and objectives, and learning ability); thus, accounting for 51% variance in the data. Conclusion: Our data suggest that there were significant weaknesses in the curriculum for off-service clinical rotations in KAMC and that residents were not completely satisfied with their training

Development and Optimization of Hybrid Polymeric Nanoparticles of Apigenin: Physicochemical Characterization, Antioxidant Activity and Cytotoxicity Evaluation

Breast cancer is the most common cancer in females and ranked second after skin cancer. The use of natural compounds is a good alternative for the treatment of breast cancer with less toxicity than synthetic drugs. The aim of the present study is to develop and characterize hybrid Apigenin (AN) Nanoparticles (NPs) for oral delivery (AN-NPs). The hybrid AN-NPs were prepared by the self-assembly method using lecithin, chitosan and TPGS. Further, the NPs were optimized by Box-Behnken design (3-factor, 3-level). The hybrid NPs were evaluated for particle size (PS), entrapment efficiency (EE), zeta potential (ZP), and drug release. The optimized hybrid NPs (ON2), were further evaluated for solid state characterization, permeation, antioxidant, cytotoxicity and antimicrobial study. The formulation (ON2) exhibited small PS of 192.6 ± 4.2 nm, high EE 69.35 ± 1.1%, zeta potential of +36.54 mV, and sustained drug release (61.5 ± 2.5% in 24 h), as well as significantly (p 50 of pure AN was found to be significantly (p p Bacillus subtilis and Salmonella typhimurium. From these findings, it revealed that a hybrid AN polymeric nanoparticle is a good carrier for the treatment of breast cancer