Nutritive evaluation of Telfairia occidentalis leaf protein concentrate in infant foods

Leaf meal (LM), leaf proteins concentrate (LPC) and LPC residues from Telfairia occidentalis were produced, chemically characterized and the protein quality of the LPC evaluated using rats. Five infant weaning foods were formulated using varying combinations of T. occidentalis LPC and soybean meal. These foods were compared with three coded commercial infant weaning foods (CFF, CFN and CFC) currently in trade in a 28-day performance study. Though fractionation increased crude protein in LPC by 34.8%, the amino acid values were in most cases lower than the FAO/WHO/UNU recommendation. Fractionation led to increase in the gross energy by 22.0% and decrease in the phytate and tannin contents by 60 and 81.3%, respectively in LPC. The LPC, when fed as sole protein source, led to weight loss in rats. The highest final weight was observed in rats fed 100% LPC + 0% soybean meal-basedfood (105.4 ± 16.4 g) and least in CFN (50.0 ± 4.2 g), a commercial food. The formulated foods had significant (

Experimental Validation of a Best-Fit Model for Predicting Radio Wave Propagation through Vegetation

In this study, a model for predicting radio wave propagation through vegetation at 900 and 1800MHz is proposed. An integrated model comprising of ground and foliage induced effects is evaluated with respect to experimental data obtained through drive test in and around a vegetation environment, using Test Mobile System (TEMS) investigation tools. Measured path loss was compared against predictions made by four empirical vegetation models. Results indicate that the European Cooperation in Science and Technology (COST) 235 model gives the best prediction and compare favourably with measured path loss in areas where vegetation is dominant. Although, this model showed the most accurate prediction of foliage loss in the investigated area, there is a need to modify it for enhanced signal prediction. The modified model was found to predict the measured path loss with Root Mean Square Errors (RMSEs) of 6.98dB and 10.00dB at 900 and 1800MHz, respectively. Overall, findings revealed that these RMSEs are within the acceptable range of up to 15.00dB, for quality signal prediction in related environment

Plasma Interferon-gamma and IL-4, Immunoglobulin Classes and Nitric Oxide in Nigerians with Acute Leukaemia

Acute leukaemia are usually rapidly progressive with death often occurring in a few weeks to a few months in untreated patients as a result of abnormal hematopoietic function as well as impaired immune response. The risk of relapse which remains in 20% of patients in remission calls for more research on acute leukaemia. This study therefore, evaluated the plasma levels of nitric oxide (NO), interleukin-4 (IL-4), interferon-gamma (IFN-γ) and immunoglobulin classes (IgA, IgG, IgM, IgE) in twenty-five (25) patients with acute leukaemia (AL) and twenty-five (25) apparently healthy controls. The mean levels of plasma IgA, IgG and IgM were not significantly elevated in leukaemia patients compared with control. However, the mean plasma levels of IgE, NO, IL-4 and IFN-γ were significantly elevated in leukaemia patients compared with controls. It could therefore be concluded from this study that humoural immunity is not depressed in acute leukaemia patients

Effect of egg sizes on egg qualities, hatchability and initial weight of the hatched-chicks

The study evaluates the relationship of egg weights with other egg qualities, hatchability and hatchling weights. One thousand eight hundred eggs from marshal broiler chicken were categorized into small (50 – 59 g), medium (60 – 69 g) and large (≥70 g) of 600 eggs per group in a completely randomized design. Hundred eggs from each group were subjected to quality analysis and the remaining incubated for hatchlings production. The egg length of of large group was the highest (4.71 cm) and lowest in small (4.22 cm). The relationship revealed 32.86% yolk in small size, while 33.71 and 30.99% was observed for medium and large respectively. Also, albumen ranged from 50.85% in small to 55.38% in large. Hatchability result revealed 74.50% for small egg and reduced as sizes increased. Hatchling weight was highest in large (49.19 g) and lowest in small (38.79 g). The regression equations showed that albumen weight and egg size were best predictors of chick's weight through their R2 values (0.68 and 0.57 respectively) compared to yolk weight with R2 of 0.28. It was therefore be inferred that breeder eggs size could affect egg quality parameters and chick's weight

A Unique Communicating Arterial Branch between the Celiac Trunk and the Superior Mesenteric Artery: A Case Report

BACKGROUND: Many anatomical variations have been associated with the Celiac Trunk, of which most are classified as being asymptomatic. CASE PRESENTATION: In this article, we describe yet another anatomical variation involving the Celiac Trunk, Superior Mesenteric artery and the Inferior Pancreaticoduodenal Artery during routine cadaveric dissection. We identified a fourth branch of the Celiac trunk (quadrification) that communicated with the Superior Mesenteric artery at the point of origin of the Inferior Pancreaticoduodenal artery which we concluded to be the Anterior Inferior Pancreaticoduodenal artery. CONCLUSION: This anastomosis could be essential in the case of occlusion between the Celiac Trunk and the Superior Mesenteric artery

The impact of industries on surface water quality of River Ona and River Alaro in Oluyole Industrial Estate, Ibadan, Nigeria

Samples of water from two rivers (River Ona and River Alaro) in Oluyole Industrial Estate, Ibadan, Nigeria were analysed to evaluate the impact of industrial discharges on the surface water quality. The results obtained indicated that most of the parameters analysed (pH, total hardness, sulphate, chloride, nitrate and dissolved solids) were lower than the World Health Organisation (WHO) maximum permissible limit for drinking water. However, the levels of nitrate, chloride, total phosphorus, total solids and oil and grease were higher in the industrial zones than those found in the upstream of both rivers. These ranged between 3.00 – 8.55, 7.48 – 11.78, 2.14 – 3.57, 260 – 520 mg/l and 381.20 – 430.80 mg/l, respectively. Nitrate and total phosphorus which are essential nutrients for plants were the most accumulated in both rivers. The gross organic pollution indicators monitored (chemical oxygen demand and oil and grease) revealed that River Alaro was more polluted than River Ona. It was established from the results of this study that industrial discharges had negative impact on the surface water qualities of both rivers. Hence, extraction of water from both rivers for domestic and agricultural purposes requires some forms of physical and chemical treatment

Evaluation of the nutrition value of Vernonia amygdalina leaf protein concentrates for infant weaning foods

Vernonia amygdalina Del leaf meal (LM), leaf protein concentrates (LPC) and LPC fibre residues (LR) were characterised and the biological activity of LPC was studied. Five infant weaning foods based on V. amygdalina -LPC (VALPC) were compared with three coded commercial infant weaning foods in a 4-week feeding trial using rats as animal model. The LM contained 318.2±2.11 g kg−1 crude protein and this increased by 38.5% to 517.4±1.20 g kg−1 in LPC. Also, the LM contained 96.0±1.8 g kg−1 crude fibre and this decreased by 81.25% to 18.0±1.1 g kg−1 in LPC. The gross energy in the LM (1.56 MJ kg−1) increased by 17.9% to 1.90 MJ kg−1 in LPC. The LPC contained higher Na, Ca, Mg, K and Fe than either the LM or LR, while fractionation reduced phytin and tannin contents. Rats fed solely on VALPC lost weight in the biological activity trial. Rats fed 25% VALPC+75% soybean meal (SBM) combination had the highest final weight (FW), while rats fed CFN, a coded commercial food, had the smallest. It was concluded that 25% VALPC+75% SBM mixture is the optimal combination

Assessment of Pharmaceuticals, Personal Care Products, and Hormones in Wastewater Treatment Plants Receiving Inflows from Health Facilities in North West Province, South Africa

The presence of 17 pharmaceutical and personal care products (PPCPs) belonging to various therapeutic categories was investigated in two hospital wastewater treatment plants (WWTPs) in North West Province, South Africa. The compounds were extracted from wastewater samples by solid-phase extraction and analysed by liquid chromatography-tandem mass spectrometry. The results showed that ofloxacin, chloramphenicol, and bezafibrate were generally below the limit of quantification (LOQ) in the analysed samples. Acetaminophen and ibuprofen were the dominant pharmaceuticals in the influent streams with corresponding concentrations ranging from 21 to 119 μg/L and 0.3 to 63 μg/L, respectively. Both WWTPs were shown to have the capability to remove some of the target PPCPs, including acetaminophen (76-98%), tetracycline (15-93%), ibuprofen (44-99%), and triclocarban (13-98%). The monitoring of the target PPCPs in both influent and effluent samples of the investigated WWTPs revealed that the discharge of inadequately treated effluents could be contributing to the possible increase in the concentrations of these contaminants in the receiving environmental compartments. Further studies must be focused on the broader characterisation of these matrices in order to assess the potential ecological impacts of this waste disposal practice

SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoids

Abstract Background Targeting viral cell entry proteins is an emerging therapeutic strategy for inhibiting the first stage of SARS-CoV-2 infection. In this study, 106 bioactive terpenoids from African medicinal plants were screened through molecular docking analysis against human angiotensin-converting enzyme 2 (hACE2), human transmembrane protease serine 2 (TMPRSS2), and the spike (S) proteins of SARS-CoV-2, SARS-CoV, and MERS-CoV. In silico absorption-distribution-metabolism-excretion-toxicity (ADMET) and drug-likeness prediction, molecular dynamics (MD) simulation, binding free energy calculations, and clustering analysis of MD simulation trajectories were performed on the top docked terpenoids to respective protein targets. Results The results revealed eight terpenoids with high binding tendencies to the catalytic residues of different targets. Two pentacyclic terpenoids (24-methylene cycloartenol and isoiguesteri) interacted with the hACE2 binding hotspots for the SARS-CoV-2 spike protein, while the abietane diterpenes were found accommodated within the S1-specificity pocket, interacting strongly with the active site residues TMPRSS2. 3-benzoylhosloppone and cucurbitacin interacted with the RBD and S2 subunit of SARS-CoV-2 spike protein respectively. These interactions were preserved in a simulated dynamic environment, thereby, demonstrating high structural stability. The MM-GBSA binding free energy calculations corroborated the docking interactions. The top docked terpenoids showed favorable drug-likeness and ADMET properties over a wide range of molecular descriptors. Conclusion The identified terpenoids from this study provides core structure that can be exploited for further lead optimization to design drugs against SARS-CoV-2 cell-mediated entry proteins. They are therefore recommended for further in vitro and in vivo studies towards developing entry inhibitors against the ongoing COVID-19 pandemic

A collective approach to reducing carbon dioxide emission: A case study of four University of Lagos Halls of residence

A major focus of existing literature on energy conservation is the modelling and quantification of energy savings and the corresponding carbon dioxide emissions from lightings. While many studies have established theoretical frameworks concerning these issues, very little documentation exists relating to energy savings and emission levels in students’ hostels. This paper considers the lighting efficiency improvement of four University of Lagos halls of residence for the purpose of quantifying energy saving and the minimization of carbon dioxide that can be made. Compact fluorescent lamps are considered alternatives to the current primary usage of conventional fluorescent and incandescent bulbs. The existing electricity consumption data obtained from energy audit are used in combination with conversion factors to estimate the annual CO2 contributed to the atmosphere by lighting in each of the buildings. The result of the study shows that over 45% reduction in carbon dioxide emission can be achieved. There is a lot individuals can do to reduce the emissions, for example, using energy saving appliances, turning off appliances when not in use, less use of fossil fuels, are simple measures that can be adopted to reduce annual carbon footprint, improve economic growth, enhance environment, health and save the planet