Induction in a von Karman flow driven by ferromagnetic impellers

We study magnetohydrodynamics in a von K\'arm\'an flow driven by the rotation of impellers made of material with varying electrical conductivity and magnetic permeability. Gallium is the working fluid and magnetic Reynolds numbers of order unity are achieved. We find that specific induction effects arise when the impeller's electric and magnetic characteristics differ from that of the fluid. Implications in regards to the VKS dynamo are discussed.Comment: 14 pages, 7 figure

A variational approach to the local character of G-closure: the convex case

This article is devoted to characterize all possible effective behaviors of composite materials by means of periodic homogenization. This is known as a $G$-closure problem. Under convexity and $p$-growth conditions ($p>1$), it is proved that all such possible effective energy densities obtained by a $\Gamma$-convergence analysis, can be locally recovered by the pointwise limit of a sequence of periodic homogenized energy densities with prescribed volume fractions. A weaker locality result is also provided without any kind of convexity assumption and the zero level set of effective energy densities is characterized in terms of Young measures. A similar result is given for cell integrands which enables to propose new counter-examples to the validity of the cell formula in the nonconvex case and to the continuity of the determinant with respect to the two-scale convergence.Comment: 24 pages, 1 figur

The CORDEX.be initiative as a foundation for climate services in Belgium

The CORDEX.be project created the foundations for Belgian climate services by producing high-resolution Belgian climate information that (a) incorporates the expertise of the different Belgian climate modeling groups and that (b) is consistent with the outcomes of the international CORDEX ("COordinated Regional Climate Downscaling Experiment") project. The key practical tasks for the project were the coordination of activities among different Belgian climate groups, fostering the links to specific international initiatives and the creation of a stakeholder dialogue. Scientifically, the CORDEX.be project contributed to the EURO-CORDEX project, created a small ensemble of High-Resolution (H-Res) future projections over Belgium at convection-permitting resolutions and coupled these to seven Local Impact Models. Several impact studies have been carried out. The project also addressed some aspects of climate change uncertainties. The interactions and feedback from the stakeholder dialogue led to different practical applications at the Belgian national level

Differential activity of methylene blue against erythrocytic and hepatic stages of Plasmodium

Background: In the context of malaria elimination/eradication, drugs that are effective against the different developmental stages of the parasite are highly desirable. The oldest synthetic anti-malarial drug, the thiazine dye methylene blue (MB), is known for its activity against Plasmodium blood stages, including gametocytes. The aim of the present study was to investigate a possible effect of MB against malaria parasite liver stages. Methods: MB activity was investigated using both in vitro and in vivo models. In vitro assays consisted of testing MB activity on Plasmodium falciparum, Plasmodium cynomolgi and Plasmodium yoelii parasites in human, simian or murine primary hepatocytes, respectively. MB in vivo activity was evaluated using intravital imaging in BALB/c mice infected with a transgenic bioluminescent P. yoelii parasite line. The transmission-blocking activity of MB was also addressed using mosquitoes fed on MB-treated mice. Results: MB shows no activity on Plasmodium liver stages, including hypnozoites, in vitro in primary hepatocytes. In BALB/c mice, MB has moderate effect on P. yoelii hepatic development but is highly effective against blood stage growth. MB is active against gametocytes and abrogates parasite transmission from mice to mosquitoes. Conclusion: While confirming activity of MB against both sexual and asexual blood stages, the results indicate that MB has only little activity on the development of the hepatic stages of malaria parasites