64 research outputs found

    Global warming induced changes in the means and extremities of temperature and precipitation in Hungary

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    Regional climate changes are still one of the most difficult problems of the climate change issue. Results by three scientific approaches, the raw General Circulation Models (GCM), the mesoscale models, compiled from the PRUDENCE project, and an empirical method, called Natural experiment are compared. The latter approach provides estimations of the future changes based on regression coefficients between the local and global variables in the monotonously warming 1976-2007 period. The global model results comprise results of 9 AOGCMs, whereas in the PRUDENCE set of 5 model outputs are analysed. The listed results start with changes in the seasonal temperature and precipitation averages. Here the signs and the magnitudes are similar according to all approaches: Faster than global mean temperature increases in all seasons, with strongly decreasing precipitation in summer and autumn but increased amounts in winter and spring. There is also a fair agreement of the three approaches in the temperature extremes of the warm half-year in Hungary, with much less unequivocal picture in the frequency of frozen days in the cold half of the year. For precipitation, again, the summer maxima of diurnal totals behave similarly according to the three approaches in all regions of the country. Namely, they exhibit unequivocal increase, whereas no clear picture is seen for frequency of wet/dry days

    VĂĄltozik-e Ă©ghajlatunk? MagyarorszĂĄgi trendek, szĂ©lsƑsĂ©gek

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    Ma mĂĄr az ĂĄtlagember is meggyƑzƑdĂ©ssel ĂĄllĂ­tja, hogy vĂĄltozik Ă©ghajlatunk. De valĂłban kimutathatĂłak-e a vĂĄltozĂĄs jelei, vagy az emberi emlĂ©kezet, esetleg az idƑjĂĄrĂĄsi esemĂ©nyekhez fƱzƑdƑ szemĂ©lyes Ă©rintettsĂ©g alkot bennĂŒnk csalĂłka kĂ©pet? CikkĂŒnkben – az OrszĂĄgos MeteorolĂłgiai SzolgĂĄlat (OMSZ) elemzĂ©seire alapozva – ezekre a kĂ©rdĂ©sekre keressĂŒk a vĂĄlaszt

    SzƑlĂ©szeti klĂ­maindexek alakulĂĄsa a mĂșlt szĂĄzad elejĂ©tƑl a Soproni borvidĂ©k terĂŒletĂ©n

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    A KƑszegen rendezett 13. SzƑlƑ Ă©s KlĂ­ma konferenciĂĄn bemutatott anyag ĂĄtdolgozĂĄsa ez a tanulmĂĄny, melynek cĂ©lja, hogy megvizsgĂĄljuk a Soproni borvidĂ©k szƑlĂ©szeti klĂ­maindexeinek vĂĄltozĂĄsait az elmĂșlt Ă©vszĂĄzad sorĂĄn, kĂŒlönös tekintettel az Ă©ghajlatvĂĄltozĂĄs hatĂĄsaira. A mĂłdszer bĂĄrmely hazai borvidĂ©kre ĂĄtĂŒltethetƑ. A Soproni borvidĂ©kre azĂ©rt esett a vĂĄlasztĂĄsunk, mert a KƑszeg környĂ©ki dƱlƑk ehhez a borvidĂ©khez tartoznak. A vizsgĂĄlt idƑszak az 1901 Ă©s 2022 közötti periĂłdus, ami lehetƑvĂ© teszi szĂĄmunkra, hogy hosszĂș tĂĄvĂș vĂĄltozĂĄsokat azonosĂ­tsunk az Ă©ghajlatban, s hogy mĂ©lyebben megĂ©rtsĂŒk a szƑlƑtermesztĂ©sre kifejtett klĂ­mahatĂĄsokat, ezĂĄltal jobban felkĂ©szĂŒlhessĂŒnk az esetleges kihĂ­vĂĄsokra

    A fƱtĂ©si foknapok vĂĄltozĂĄsa a mĂșlt szĂĄzad elejĂ©tƑl napjainkig

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    A fƱtĂ©si foknap az idƑjĂĄrĂĄstĂłl fĂŒggƑ energiafogyasztĂĄs egy mutatĂłja. A mĂșlt szĂĄzad elejĂ©tƑl napjainkig (1901–2021) elemezzĂŒk MagyarorszĂĄg egĂ©sz terĂŒletĂ©re ezt a mutatĂłt. Az orszĂĄgos ĂĄttekintĂ©s mellett nĂ©hĂĄny kivĂĄlasztott mĂ©rƑhelyre kĂŒlön is közlĂŒnk eredmĂ©nyeket. A 2022/2023-as, enyhe idƑjĂĄrĂĄssal jellemezhetƑ fƱtĂ©si szezon mĂ©rƑszĂĄmaira is kitĂ©rĂŒnk, összevetjĂŒk az aktuĂĄlis foknap Ă©rtĂ©keket a sokĂ©vi ĂĄtlaggal. ÖsszessĂ©gĂ©ben elmondhatĂł, hogy a melegedƑ tendenciĂĄval összhangban az egĂ©sz orszĂĄgban csökkentek a fƱtĂ©si foknapok Ă©ves, valamint havi összegei, a legnagyobb mĂ©rtĂ©kben a hegyvidĂ©ki terĂŒleteken Ă©s Nyugat-MagyarorszĂĄgon. A csökkenĂ©s az orszĂĄg minden pontjĂĄn jelentƑs, statisztikailag szignififikĂĄns a XX. szĂĄzad kezdete Ăłta

    Increased nociceptin/orphanin FQ plasma levels in hepatocellular carcinoma

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    AIM: The heptadecapeptide nociceptin alias orphanin FQ is the endogenous agonist of opioid receptor-like1 receptor. It is involved in modulation of pain and cognition. High blood level was reported in patients with acute and chronic pain, and in Wilson disease. An accidental observation led us to investigate nociceptin in hepatocellular carcinoma. METHODS: Plasma nociceptin level was measured by radioimmunoassay, aprotinin was used as protease inhibitor. Hepatocellular carcinoma was diagnosed by laboratory, ultrasound, other imaging, and confirmed by fine needle biopsy. Results were compared to healthy controls and patients with other chronic liver diseases. RESULTS: Although nociceptin levels were elevated in patients with Wilson disease (14.0 +/- 2.7 pg/mL, n = 26), primary biliary cirrhosis (12.1 +/- 3.2 pg/mL, n = 21) and liver cirrhosis (12.8 +/- 4.0 pg/mL, n = 15) compared to the healthy controls (9.2 +/- 1.8 pg/mL, n = 29, P < 0.001 for each), in patients with hepatocellular carcinoma a ten-fold increase was found (105.9 &PLUSMN; 14.4 pg/mL, n = 29, P < 0.0001). High plasma levels were found in each hepatocellular carcinoma patient including those with normal alpha fetoprotein and those with pain (104.9 +/- 14.9 pg/mL, n = 12) and without (107.7 +/- 14.5 pg/mL, n = 6). CONCLUSION: A very high nociceptin plasma level seems to be an indicator for hepatocellular carcinoma. Further research is needed to clarify the mechanism and clinical significance of this novel finding

    Rising plasma nociceptin level during development of HCC: A case report

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    AIM: Although liver cirrhosis is a predisposing factor for hepatocellular carcinoma (HCC), relatively few reports are available on HCC in primary biliary cirrhosis. High plasma nociceptin (N/OFQ) level has been shown in Wilson disease and in patients with acute and chronic pain. METHODS: We report a follow-up case of HCC, which developed in a patient with primary biliary cirrhosis. The tumor appeared 18 years after the diagnosis of PBC and led to death within two years. Alfa fetoprotein and serum nociceptin levels were monitored before and during the development of HCC. Nociceptin content was also measured in the tumor tissue. RESULTS: The importance and the curiosity of the presented case was the novel finding of the progressive elevation of plasma nociceptin level up to 17-fold (172 pg/mL) above the baseline (9.2 +/- 1.8 pg/mL) parallel with the elevation of alpha fetoprotein (from 13 ng/mL up to 3 480 ng/mL) during tumor development. Nociceptin content was more than 15-fold higher in the neoplastic tissue (0.16 pg/mg) than that in the tumor-free liver tissue samples (0.01 pg/mg) taken during the autopsy. CONCLUSION: Results are in concordance with our previous observation that a very high plasma nociceptin level may be considered as an indicator for hepatocellular carcinoma
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