Vaprad hobused

Loovpraktilise lõputöö kirjalikus osas annab autor ülevaate õpingutest TÜ VKAs, sellele eelnenud perioodist, diplomikontserti kontseptsioonist, repertuaarist, prooviperioodist ja kaasategevatest muusikutest. Õpingute perioodis annab ülevaate kolmest olulisest etapist muusikaga kokkupuutumisel. Diplomikontserti kontseptsioonis selgitab, kuidas looming on sündinud ja millest on saanud inspiratsiooni. Repertuaari osas selgitab lahti kontserdil mängitavate palade sisu ning analüüsib esitusele tulevate lugude vormilist struktuuri. Prooviperioodi peatükis annab autor ülevaate proovides toimunust ja iseloomustab lühidalt muusikuid, kes autoriga koos laval on.https://www.ester.ee/record=b5447586*es

Regulation of extracellular serotonin levels and brain-derived neurotrophic factor in rats with high and low exploratory activity

Serotonin (5-HT) system has a significant role in anxiety- and depression-related states and may be influenced by brain-derived neurotrophic factor (BDNF). This study examined extracellular 5-HT levels and expression of BDNF in rats with persistently low or high levels of exploratory activity (LE and HE, respectively). Baseline extracellular levels of 5-HT as assessed by in vivo microdialysis in conscious animals were similar in both groups in medial prefrontal cortex (PFC) and dentate gyrus (DG). No differences were found in parachloroamphetamine-induced 5-HT release in either region. However, LE animals had significantly higher levels of 5-HT transporter (5-HTT) binding in PFC and a larger increase in extracellular 5-HT levels after administration of citalopram (1 μM) into this area by retrograde dialysis. No difference in 5-HTT levels was found in hippocampus, while perfusion with citalopram was accompanied by a greater increase in extracellular 5-HT in the HE group in this brain region. LE-rats had higher levels of BDNF mRNA in the PFC but not hippocampus. In contrast, levels of nerve growth factor mRNA were similar in these brain regions of LE- and HE-rats. The differential regulation of 5-HT-ergic system in LE- and HE-rats in PFC and hippocampus may form the basis for their distinct anxiety-related behaviours