Formation mechanism of the Vaasa Batholith in the Fennoscandian Shield : petrographic and geochemical constraints

Peer reviewe

The Helsinki approach to face transplantation

Aim: We herein describe the establishment of the Helsinki Vascularized Composite Allotransplantation (VCA) program and its execution in the first two face transplant cases. Methods & patients: The Helsinki VCA program initially required the fulfillment of legal, hospital, financial, and ethical requirements. Thereafter, the assembling of a multidisciplinary team commenced. A team of Plastic, maxillofacial and ENT surgeons comprise the facial VCA team. The protocol involves collaboration with the Solid Organ Transplant (SOT) team, transplant immunology, immunosuppression, microbiology, psychiatric evaluation, well-defined VCA indications and informed consent. Between 2011 and 2017 two patients were selected for transplantation. Both patients had a severe composite facial deformity involving the maxilla and mandible following earlier ballistic injury. Results: Patient 1 was a 35 year-old male who underwent successful near total face transplantation in February 2016 and at 30 months he has a good aesthetic outcome with symmetrical restoration of the central face and good sensory and symmetrical motor functional outcomes. Patient 2 was a 58 year-old male who underwent full face transplantation in March 2018 and at 5 months he has recovered without major problems. Conclusion: A successful facial VCA program requires a well-prepared research protocol, experts from multiple specialties and careful patient selection. The establishment of the Helsinki VCA program required long and thorough planning and resulted in the first two Nordic face transplantation cases. This protocol now forms the platform (as a proof of concept) for other types of vascularized composite allotransplantations. (C) 2018 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.Peer reviewe

Long-term Outcome of Kidney Transplantation in 6 Patients With Autoimmune Polyendocrinopathy-candidiasis-ectodermal Dystrophy

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Kliinisen lääketieteen tohtorikoulutus tarjoaa tänään rakenteellisesti aiempaa suunnitellumman tutkijankoulutuksen

English summar

Factors Affecting the Control of Chronic Rhinosinusitis With Nasal Polyps : A Comparison in Patients With or Without NERD

Objectives: The aim was to compare the control of chronic rhinosinusitis with nasal polyps (CRSwNP) after endoscopic sinus surgery (ESS), in patients with/without nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD). Study Desing: A retrospective hospital-based sample of CRSwNP patients with/without NERD with follow-up. Setting: Tertiary rhinology centers. Methods: Electronic patient record data from 116 CRSwNP patients (46 with NERD and 70 without NERD) undergoing ESS during 2001-17 were studied. Mean follow-up time was 9.9 years (range 1.1-15.3). Endpoints reflecting uncontrolled CRSwNP were revision ESS, and need for rescue/advanced therapy (e.g. antibiotics, oral corticosteroids and/or biological therapy) during follow-up. NERD was variable of interest and gender, age, asthma, allergic rhinitis (AR), smoking, Lund-Mackay (LM) score of sinus computed tomography scans previous ESS and baseline total ethmoidectomy were used as covariates. Results: Twenty-one (49.7%) NERD patients and 18 (25.7%) non-NERD patients underwent revision ESS within a mean +/- SD of 4.3 +/- 2.8 and 3.7 +/- 2.6 years, respectively (p = .013, by Logrank test). In Cox ' s regression models, NERD, female gender, young age, asthma, AR, previous ESS, and lack of total ethmoidectomy were associated with revision-ESS. In adjusted model, only the total ethmoidectomy predicted revision-free survival. In adjusted logistic regression model, there was an insignificant trend that NERD and LM score were associated with the need for rescue/advanced therapy in the follow-up. Conclusions: Patients with NERD had higher risk of uncontrolled CRSwNP than patient group without NERD, as measured by revision ESS and/or need for rescue/advanced therapy in the follow-up. In addition, baseline total ethmoidectomy was associated with revision-free survival.Peer reviewe

Season, dietary factors, and physical activity modify 25-hydroxyvitamin D concentration during pregnancy

Peer reviewe

Puolustusvoimien kokeilutoiminta sotavuosina 1939-1944. Kokeilutoiminnan historialliset juuret, osa II

Puolustusvoimien kokeilutoiminta sotavuosina 1939– 1944. Kokeilutoiminnan historialliset juuret, osa II -teos on toinen osa teossarjasta, jossa käsitellään Puolustusvoimien kokeilutoimintaa Suomen itsenäistymisestä kylmän sodan päättymiseen. Puolustusvoimissa sotavuosina suunniteltu ja toteutettu kokeilutoiminta muodostaa hyvin monipuolisen tutkimuskohteen. Kirjan keskiössä ovat sotavarustuksen, aseistuksen ja sotataidon kehittämistä koskeneet kokeilut. Kirjaan kirjoittaneiden yhdeksäntoista sotahistorian osaajan artikkeleissa todentuu se, että kokeilutoiminnalla oli tärkeä rooli Suomen puolustusvoimien kehityksessä sotavuosina 1939–1944. Talvisodan, välirauhan ja jatkosodan aikana Puolustusvoimien sotavarustus, asetekniikka ja sotataidollinen osaaminen kehittyivät huimasti. Kokeilutoiminnan onnistumisten ja puutteiden vaikutukset todentuivat konkreettisesti taistelukentillä