One-step generation of high-quality squeezed and EPR states in cavity QED

We show how to generate bilinear (quadratic) Hamiltonians in cavity quantum electrodynamics (QED) through the interaction of a single driven three-level atom with two (one) cavity modes. With this scheme it is possible to generate one-mode mesoscopic squeezed superpositions, two-mode entanglements, and two-mode squeezed vacuum states (such the original EPR state), without the need for Ramsey zones and external parametric amplification. The degree of squeezing achieved is up to 99% with currently feasible experimental parameters and the errors due to dissipative mechanisms become practically negligible

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T cells, B cells, monocytes, and fibroblasts from 51 samples of synovial tissue from patients with RA or osteoarthritis (OA). Utilizing an integrated strategy based on canonical correlation analysis of 5,265 scRNA-seq profiles, we identified 18 unique cell populations. Combining mass cytometry and transcriptomics revealed cell states expanded in RA synovia: THY1(CD90) + HLA-DRA hi sublining fibroblasts, IL1B + pro-inflammatory monocytes, ITGAX + TBX21 + autoimmune-associated B cells and PDCD1 + peripheral helper T (T PH ) cells and follicular helper T (T FH ) cells. We defined distinct subsets of CD8 + T cells characterized by GZMK + , GZMB + , and GNLY + phenotypes. We mapped inflammatory mediators to their source cell populations; for example, we attributed IL6 expression to THY1 + HLA-DRA hi fibroblasts and IL1B production to pro-inflammatory monocytes. These populations are potentially key mediators of RA pathogenesis

Coupled TRNSYS-CFD simulations evaluating the performance of PCM plate heat exchangers in an Airport Terminal building displacement conditioning system

This is the post-print version of the Article. The official published version can be accessed from the link below. Copyright @ 2013 Elsevier.This paper reports on the energy performance evaluation of a displacement ventilation (DV) system in an airport departure hall, with a conventional DV diffuser and a diffuser retrofitted with a phase change material storage heat exchanger (PCM-HX). A TRNSYS-CFD quasi-dynamic coupled simulation method was employed for the analysis, whereby TRNSYS® simulates the HVAC and PID control system and ANSYS FLUENT® is used to simulate the airflow inside the airport terminal space. The PCM-HX is also simulated in CFD, and is integrated into the overall model as a secondary coupled component in the TRNSYS interface. Different night charging strategies of the PCM-HX were investigated and compared with the conventional DV diffuser. The results show that: i) the displacement ventilation system is more efficient for cooling than heating a space; ii) the addition of a PCM-HX system reduces the heating energy requirements during the intermediate and summer periods for specific night charging strategies, whereas winter heating energy remains unaffected; iii) the PCM-HX reduces cooling energy requirements, and; iv) maximum energy savings of 34% are possible with the deployment of PCM-HX retrofitted DV diffuser.This work was funded by the UK Engineering and Physical Sciences Research Council (EPSRC), Grant No: EP/H004181/1