The novels of Maurice Gee (1962-1994) : Gee's New Zealand : in the throes of entropy : a thesis in partial fulfilment of the requirements for the degree of Master of Arts in English at Massey University

This inquiry explores the dualistic aspects of Maurice Gee's novels, particularly with reference to Prowlers and Going West. I will be highlighting the juxtaposition of opposing characters (the observers and the doers), and the opposition of mind and body - of idealism and empiricism - as developed in these two novels. I will also be investigating how Gee's novels explore the dynamics of human relationships, accounting for the recurrent themes of language, fear, death, love and madness, as they appear in his oeuvre. Chapter three explores how Gee's fiction deals with the difficulties of writing an objective account of someone's life. All these areas of investigation reveal an overall view that Gee's New Zealand society has gradually shifted towards a state of chaos and uncertainty within the last one hundred years. In chapter one I will explore the images and events, as depicted in Gee's autobiographical essay "Beginnings," that have shaped his creative imagination. I will show how they have been transformed, or re-worked, in his fiction, as well as how and why they stress the importance of imagination. I will be arguing how, through his characters, Gee continues to exorcise the traumas, conflicts and confusions of his own past, as well as demonstrating the didactic functions given to this process by his subjecting his main characters to similar experiences. I will show how Gee investigates the negative effects of a puritan heritage, and ultimately, how it can be damaging to the growing and developing adolescent psyche, causing confusion, and distorting one's perception of the real, particularly in the way it is expressed in the novel In My Father's Den. I will show how Gee's abhorrence of 'bureaucratic and institutional repression' is expressed in The Big Season, and the 'O' trilogy - at the level of community, - and in the two novels, The Special Flower and Games of Choice - at the level of family. More specifically, I will show how the narratives emphasize the need for the individual to break away from these constricting forces in order to find his own shape, and achieve a firm sense of personal identity. I will inquire into the ways in which Gee explores the idea of 'the mixed nature of the human condition' in the 'O' trilogy, and will commence a discussion of how this theme is developed in Prowlers and Going West, which will be expanded in the remaining two chapters. I will discuss how the sense of feeling 'special,' and of being in possession of 'special knowledge', can create the illusion of feeling privileged, but also how this can be seen as a burden, and how it can generate a sense of 'isolation,' thereby alienating the individual from the outside world. I will show how Gee's vision of the world can be interpreted as dualistic

Evidence for Decline in the Unionidae of the East Branch Rocky River, Ohio

A survey of freshwater mussels (Mollusca: Bivalvia: Unionidae) was conducted for the East Branch Rocky River, Ohio, during the summer of 2006. Development in this watershed is moderate though rapidly expanding, particularly in the upstream reaches. Perhaps as a consequence, a preliminary search failed to reveal any live mussels in the river in 2003 . The present report is of an extensive survey covering 21 two-hour timed searches for live mussels and shells combined with visual assessments of disturbance and tests for water quality at each site. All searches were visual or by feeling for mussels embedded in the stream bottom where visibili ty was poor. These surveys produced only 34 live animals and 287 empty shells, which included live specimens of Lampsilis radiata /uteo/a, Lasmigona costata, Lasmigona compressa, and Strophitus undulatus as well as fresh shells of Pyganodon grandis. The few sites that contained live animals and fresh shells were isolated, while worn shells were distributed more evenly throughout the river, suggesting a wider distribution of mussels in the past. Present water quality appeared good, and, therefore, the relatively low density and spatial isolation of unionids may reflect local geomorphologic factors combined with historic and current land usage

Assessing Causes of Change in the Freshwater Mussels (Bivalvia: Unionidae) in the Black River, Ohio

Habitat destruction is believed to be the number one cause of the decline in unionid mussels. Around the world, cities, towns and agriculture alter the structure of watersheds, and the Black River in Ohio may be a typical example. We investigated the diversity and abundance of unionid mussels in this watershed and compared results to urbanization locations, to site-specific appearance of the habitat and to a 1997 fish survey, as host species are another factor important to the distribution of unionid mussels. Although shells were found for 21 species, only 11 of these species were found alive. Seven of the species represented only by shells occurred only in the urbanized lower main stem of the river and less than five shells were found for each. Most of these shells were old and worn. Furthermore, the present assemblage in the main stem varied from shells obtained at a nearby archeological site, and from a voucher set of species obtained at the turn of the 20th Century. Mussel communities higher in the river and those in tributaries were less diverse, but abundance of the species present was higher than in the main stem. A lack of fish hosts may limit mussel diversity, as hosts for several species present in the main stem do not reside higher in the watershed. Overall, mussel assemblages in the Black River appear typical for the region with relatively abundant, but low diversity communities upstream of the cities that line Lake Erie\u27s coast and diverse, but small and potentially threatened, populations in the urban regions

Commentary: Essential Programs and Services Model

To further discussion about the Essential Programs and Services (EPS) model for funding public education in Maine, Maine Policy Review asked eight superintendents—representing districts across the state— to provide their views. We also asked each to discuss the needs of his district and whether additional state policy options were necessary to tackle the most pressing issues. The districts represented by these superintendents are a cross section of urban and rural high-receivers and low-receivers. Still, several commonalities emerge: the need for a state commitment that does not wax and wane with the business cycle; the urgency of professional development for new and experienced teachers; and, the importance of linking student outcomes with student assessment measures and student funding. In short, EPS is not seen as a solution to the state’s ongoing debate over public-education funding, but is recognized as a necessary first step

Epilepsy, antiepileptic drugs, and the risk of major cardiovascular events

ObjectiveThis study was undertaken to determine whether epilepsy and antiepileptic drugs (including enzyme-inducing and non-enzyme-inducing drugs) are associated with major cardiovascular events using population-level, routinely collected data.MethodsUsing anonymized, routinely collected, health care data in Wales, UK, we performed a retrospective matched cohort study (2003–2017) of adults with epilepsy prescribed an antiepileptic drug. Controls were matched with replacement on age, gender, deprivation quintile, and year of entry into the study. Participants were followed to the end of the study for the occurrence of a major cardiovascular event, and survival models were constructed to compare the time to a major cardiovascular event (cardiac arrest, myocardial infarction, stroke, ischemic heart disease, clinically significant arrhythmia, thromboembolism, onset of heart failure, or a cardiovascular death) for individuals in the case group versus the control group.ResultsThere were 10 241 cases (mean age = 49.6 years, 52.2% male, mean follow-up = 6.1 years) matched to 35 145 controls. A total of 3180 (31.1%) cases received enzyme-inducing antiepileptic drugs, and 7061 (68.9%) received non-enzyme-inducing antiepileptic drugs. Cases had an increased risk of experiencing a major cardiovascular event compared to controls (adjusted hazard ratio = 1.58, 95% confidence interval [CI] = 1.51–1.63, p < .001). There was no notable difference in major cardiovascular events between those treated with enzyme-inducing antiepileptic drugs and those treated with non-enzyme-inducing antiepileptic drugs (adjusted hazard ratio = .95, 95% CI = .86–1.05, p = .300).SignificanceIndividuals with epilepsy prescribed antiepileptic drugs are at an increased risk of major cardiovascular events compared with population controls. Being prescribed an enzyme-inducing antiepileptic drug is not associated with a greater risk of a major cardiovascular event compared to treatment with other antiepileptic drugs. Our data emphasize the importance of cardiovascular risk management in the clinical care of people with epilepsy

Material condition assessment with eddy current sensors

Eddy current sensors and sensor arrays are used for process quality and material condition assessment of conducting materials. In an embodiment, changes in spatially registered high resolution images taken before and after cold work processing reflect the quality of the process, such as intensity and coverage. These images also permit the suppression or removal of local outlier variations. Anisotropy in a material property, such as magnetic permeability or electrical conductivity, can be intentionally introduced and used to assess material condition resulting from an operation, such as a cold work or heat treatment. The anisotropy is determined by sensors that provide directional property measurements. The sensor directionality arises from constructs that use a linear conducting drive segment to impose the magnetic field in a test material. Maintaining the orientation of this drive segment, and associated sense elements, relative to a material edge provides enhanced sensitivity for crack detection at edges

Tissue-preserving approach to extracting DNA from paraffin-embedded specimens using tissue microarray technology

Background. DNA extracted from tumor cells or normal cells contained in formalin-fixed, paraffin-embedded tissues is widely used in many laboratories. The 2 most common procedures to isolate cells for DNA extraction from paraffin-embedded tissues are scalpel microdissection and laser capture microdissection. A new tissue- and time-conserving method for rapid DNA isolation from small cores taken from paraffin-embedded tissue blocks is described in this report. Methods. DNA was extracted from small tissue cores collected from paraffin-embedded tissue blocks at the time of tissue microarray construction. The quality and quantity of the DNA extracted was compared to DNA collected by scalpel microdissection. DNA collected from tissue cores was used in polymerase chain reaction (PCR) and loss of heterozygosity (LOH) analysis. Results. The quality and quantity of DNA obtained using tissue cores was comparable to DNA obtained by traditional methods. The tissue core method of DNA extraction preserves the tissue blocks from which the cores are extracted for future use. Adequate quantities of DNA can be successfully extracted from small segments of tissue cores and used for PCR. DNA isolated by tissue microdissection and the tissue core method were comparable when used to assess allelic heterozygosity on chromosome arm 18q. Conclusion. The tissue core method of DNA isolation is reliable, tissue conserving, and time effective. Tissue cores for DNA extraction can be harvested at the same time as tissue microarray construction. The technique has the advantage of preserving the original tissue blocks for additional study as only tiny cores are removed. © 2007 Wiley Periodicals, Inc. Head Neck, 2007Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/56021/1/20547_ftp.pd

A randomised study of rituximab and belimumab sequential therapy in PR3 ANCA-associated vasculitis (COMBIVAS): design of the study protocol

Background: Sequential B cell-targeted immunotherapy with BAFF antagonism (belimumab) and B cell depletion (rituximab) may enhance B cell targeting in ANCA-associated vasculitis (AAV) through several mechanisms. Methods: Study design: COMBIVAS is a randomised, double-blind, placebo-controlled trial designed to assess the mechanistic effects of sequential therapy of belimumab and rituximab in patients with active PR3 AAV. The recruitment target is 30 patients who meet the criteria for inclusion in the per-protocol analysis. Thirty-six participants have been randomised to one of the two treatment groups in a 1:1 ratio: either rituximab plus belimumab or rituximab plus placebo (both groups with the same tapering corticosteroid regimen), and recruitment is now closed (final patient enrolled April 2021). For each patient, the trial will last for 2 years comprising a 12-month treatment period followed by a 12-month follow-up period. Participants: Participants have been recruited from five of seven UK trial sites. Eligibility criteria were age ≥ 18 years and a diagnosis of AAV with active disease (newly diagnosed or relapsing disease), along with a concurrent positive test for PR3 ANCA by ELISA. Interventions: Rituximab 1000 mg was administered by intravenous infusions on day 8 and day 22. Weekly subcutaneous injections of 200 mg belimumab or placebo were initiated a week before rituximab on day 1 and then weekly through to week 51. All participants received a relatively low prednisolone (20 mg/day) starting dose from day 1 followed by a protocol-specified corticosteroid taper aiming for complete cessation by 3 months. Outcomes: The primary endpoint of this study is time to PR3 ANCA negativity. Key secondary outcomes include change from baseline in naïve, transitional, memory, plasmablast B cell subsets (by flow cytometry) in the blood at months 3, 12, 18 and 24; time to clinical remission; time to relapse; and incidence of serious adverse events. Exploratory biomarker assessments include assessment of B cell receptor clonality, B cell and T cell functional assays, whole blood transcriptomic analysis and urinary lymphocyte and proteomic analysis. Inguinal lymph node and nasal mucosal biopsies have been performed on a subgroup of patients at baseline and month 3. Discussion: This experimental medicine study provides a unique opportunity to gain detailed insights into the immunological mechanisms of belimumab-rituximab sequential therapy across multiple body compartments in the setting of AAV. Trial registration: ClinicalTrials.gov NCT03967925. Registered on May 30, 2019