Troponin T-release associates with cardiac radiation doses during adjuvant left-sided breast cancer radiotherapy

Background Adjuvant radiotherapy (RT) for left-sided breast cancer increases cardiac morbidity and mortality. For the heart, no safe radiation threshold has been established. Troponin T is a sensitive marker of myocardial damage. Our aim was to evaluate the effect of left-sided breast cancer RT on serum high sensitivity troponin T (hscTnT) levels and its association with cardiac radiation doses and echocardiographic parameters. Methods A total of 58 patients with an early stage, left-sided breast cancer or ductal carcinoma in situ (DCIS) who received adjuvant breast RT without prior chemotherapy were included in this prospective, non-randomized study. Serum samples were taken before, during and after RT. An increase of hscTnT >30 % was predefined as significant. A comprehensive 2D echocardiograph and electrocardiogram (ECG) were performed before and after RT. Dose-volume histograms (DVHs) were generated for different cardiac structures. Results The hscTnT increased during RT from baseline in 12/58 patients (21 %). Patients with increased hscTnT values (group A, N = 12) had significantly higher radiation doses for the whole heart (p = 0.02) and left ventricle (p = 0.03) than patients without hscTnT increase (group B, N = 46). For the left anterior descending artery (LAD), differences between groups A and B were found in volumes receiving 15 Gy (p = 0.03) and 20 Gy (p = 0.03) Furthermore, after RT, the interventricular septum thickened (p = 0.01), and the deceleration time was prolonged (p = 0.008) more in group A than in group B. Conclusions The increase in hscTnT level during adjuvant RT was positively associated with the cardiac radiation doses for the whole heart and LV in chemotherapy-naive breast cancer patients. Whether these acute subclinical changes increase the risk of excessive long-term cardiovascular morbidity or mortality, will be addressed in the follow-up of our patients.BioMed Central open acces

Changes in thyroid hormones after acute myocardial infarction: clinical and experimental study

This study investigated whether changes in thyroid hormone (TH) in plasmaare associated with the recovery of cardiac function in patients with acutemyocardial infarction (AMI). Previous experimental studies have providedevidence of potential implication of TH signaling in post-ischemic recovery ofcardiac function.A total of 47 patients with AMI and early reperfusion therapy were included inthis study. injury was analyzed by peak creatinine kinase-MB (CKMB) andcardiac function was assessed by echocardiographic left ventricular ejectionfraction (LVEF%). Recovery of function (ΔEF%) was estimated as thedifference of LVEF% between 48 h and 6 months (6 mo) after AMI. Totaltriiodothyronine (T(3)), thyroxine (T(4)), and TSH were measured in plasma atdifferent time points (24 h, 48 h, 5 d, and 6 mo).A significant correlation between LVEF% and T(3) (r=0.5, P=0.0004) wasfound early after AMI (48 h), whereas no correlation was observed betweenCKMB and T(3) (r=-0.04, P=0.81). A strong correlation was found betweenΔEF% and total T(3) (r=0.64, P=10(-6)) at 6 mo after AMI. Furthermore,multivariate regression analysis revealed that T(3) at 6 mo (r=0.64, r(2)=0.41,P=10(-6)) was an independent determinant of ΔEF%.Changes in T(3) levels in plasma are closely correlated with the early and laterecovery of cardiac function after AMI. T(3) levels at 6 mo appear to be anindependent predictor of late functional recovery.Θυρεοειδική ορμόνη και ανάκτηση της καρδιακής λειτουργίας σε ασθενείς μεοξύ έμφραγμα του μυοκαρδίου: μια ισχυρή συσχέτιση;Η παρούσα μελέτη διερεύνησε κατά πόσο οι αλλαγές στην ορμόνη τουθυρεοειδούς (Θ) στο πλάσμα συνδέεται με την ανάκτηση της καρδιακήςλειτουργίας σε ασθενείς με οξύ έμφραγμα του μυοκαρδίου (ΟΕΜ).Προηγούμενες πειραματικές μελέτες υποστηρίζουν πιθανή εμπλοκή της THστην μετα-ισχαιμική αποκατάσταση της καρδιακής λειτουργίας.Στη μελέτη έλαβε μέρος ένα σύνολο 47 ασθενών με ΟΕΜ και έγκαιρηθεραπεία επαναιμάτωσης. Η καρδιακή βλάβη μετρήθηκε από τη μέγιστη τιμήCKMB(κρεατινίνη κινάση), και η καρδιακή λειτουργία εκτιμήθηκευπερηχογραφηματικά, με προσδιορισμό του κλάσματος εξωθήσεως τηςαριστερής κοιλίας (LVEF%). Ανάκτηση της λειτουργίας (ΔEF%) υπολογίστηκεως η διαφορά του% LVEF μεταξύ 48 ωρών και 6 μηνών, μετά από οξύέμφραγμα του μυοκαρδίου. Η ολική τριϊωδοθυρονίνη (Τ(3)), η θυροξίνη (Τ(4)),και η TSH μετρήθηκαν στο πλάσμα σε διάφορα χρονικά σημεία (24 ώρες, 48ώρες, 5 ημέρες, και 6 μήνες).Μια σημαντική συσχέτιση μεταξύ LVEF% και T (3) (r = 0,5, P = 0.0004)βρέθηκε νωρίς μετά AMI (48 ώρες), ενώ δεν παρατηρήθηκε συσχέτιση μεταξύτης CKMB και Τ (3) (r = -0.04, P = 0,81). Μια ισχυρή συσχέτιση βρέθηκεμεταξύ ΔEF% και T (3) (r = 0,64, P = 10 (-6)) στους 6 μήνες μετά το οξύέμφραγμα του μυοκαρδίου. Επιπλέον, πολυπαραγοντική ανάλυσηπαλινδρόμησης αποκάλυψε ότι η T (3) σε 6 μήνες (r = 0,64, r (2) = 0,41, P =10 (-6)) ήταν ανεξάρτητος προγνωστικός παράγοντας της ανάκτησης τηςκαρδιακής λειτουργίας.Οι αλλαγές στα επίπεδα Τ (3) στο πλάσμα συσχετίζονται στενά με την πρώιμηκαι την όψιμη ανάκτηση της καρδιακής λειτουργίας μετά από ΟΕΜ. T (3)επίπεδα σε 6 μήνες φαίνεται να αποτελούν ανεξάρτητο προγνωστικόπαράγοντα της όψιμης καρδιακής αποκατάστασης

Thyroid hormone and recovery of cardiac function in patients with acute myocardial infarction: A strong association?

Objective: This study investigated whether changes in thyroid hormone (TH) in plasma are associated with the recovery of cardiac function in patients with acute myocardial infarction (AMI). Previous experimental studies have provided evidence of potential implication of TH signaling in post-ischemic recovery of cardiac function. Methods: A total of 47 patients with AMI and early reperfusion therapy were included in this study. Myocardial injurywas analyzed by peak creatinine kinase-MB(CKMB) and cardiac function was assessed by echocardiographic left ventricular ejection fraction (LVEF%). Recovery of function (ΔEF%) was estimated as the difference of LVEF% between 48 h and 6 months (6 mo) after AMI. Total triiodothyronine (T3), thyroxine (T4), and TSH were measured in plasma at different time points (24 h, 48 h, 5 d, and 6 mo). Results: A significant correlation between LVEF% and T3 (r=0.5, P=0.0004) was found early after AMI (48 h), whereas no correlation was observed between CKMB and T3 (r=-0.04, P=0.81). A strong correlation was found between ΔEF% and total T3 (r=0.64, P=10-6) at 6 mo after AMI. Furthermore, multivariate regression analysis revealed that T3 at 6 mo (r=0.64, r2=0.41, P=10-6) was an independent determinant of DEF%. Conclusion: Changes in T3 levels in plasma are closely correlated with the early and late recovery of cardiac function after AMI. T3 levels at 6 mo appear to be an independent predictor of late functional recovery. © 2011 European Society of Endocrinology

Thyroid hormone and recovery of cardiac function in patients with acute myocardial infarction: a strong association?

Objective: This study investigated whether changes in thyroid hormone (TH) in plasma are associated with the recovery of cardiac function in patients with acute myocardial infarction (AMI). Previous experimental studies have provided evidence of potential implication of TH signaling in post-ischemic recovery of cardiac function. Methods: A total of 47 patients with AMI and early reperfusion therapy were included in this study. Myocardial injurywas analyzed by peak creatinine kinase-MB(CKMB) and cardiac function was assessed by echocardiographic left ventricular ejection fraction (LVEF%). Recovery of function (ΔEF%) was estimated as the difference of LVEF% between 48 h and 6 months (6 mo) after AMI. Total triiodothyronine (T3), thyroxine (T4), and TSH were measured in plasma at different time points (24 h, 48 h, 5 d, and 6 mo). Results: A significant correlation between LVEF% and T3 (r=0.5, P=0.0004) was found early after AMI (48 h), whereas no correlation was observed between CKMB and T3 (r=-0.04, P=0.81). A strong correlation was found between ΔEF% and total T3 (r=0.64, P=10-6) at 6 mo after AMI. Furthermore, multivariate regression analysis revealed that T3 at 6 mo (r=0.64, r2=0.41, P=10-6) was an independent determinant of DEF%. Conclusion: Changes in T3 levels in plasma are closely correlated with the early and late recovery of cardiac function after AMI. T3 levels at 6 mo appear to be an independent predictor of late functional recovery. © 2011 European Society of Endocrinology

Quality of life, anxiety, and depression in the head-and-neck cancer patients, undergoing intensity-modulated radiotherapy treatment

Aims: The aim of this study is to investigate and compare distress and quality-of-life parameters among head-and-neck cancer patients who underwent intensity-modulated radiotherapy (IMRT). Subjects and Methods: The patients' sample consists of 55 individuals under IMRT treatment. Three questionnaires (Quality of Life Questionnaire [QLQ]-C30 and QLQ-H and N35) of the European Organization for the Research and Treatment of Cancer and the Greek Hospital Anxiety and Depression Scales were used. Results: Functioning and symptoms scales measured a week before the scheduled treatment worsen significantly until the end of the treatment and at the 3-month follow-up, tend to revert to their pretreatment values. Conclusions: Our results showed that all parameters (functioning scales, symptoms scales, and G-HAD subscales) worsen from the start to the end treatment and tend to revert to their pretreatment values after a 3-month period. © 2020 Indian Journal of Palliative Care