Informed Bayesian T-Tests

Across the empirical sciences, few statistical procedures rival the popularity of the frequentist t-test. In contrast, the Bayesian versions of the t-test have languished in obscurity. In recent years, however, the theoretical and practical advantages of the Bayesian t-test have become increasingly apparent and various Bayesian t-tests have been proposed, both objective ones (based on general desiderata) and subjective ones (based on expert knowledge). Here we propose a flexible t-prior for standardized effect size that allows computation of the Bayes factor by evaluating a single numerical integral. This specification contains previous objective and subjective t-test Bayes factors as special cases. Furthermore, we propose two measures for informed prior distributions that quantify the departure from the objective Bayes factor desiderata of predictive matching and information consistency. We illustrate the use of informed prior distributions based on an expert prior elicitation effort

Bidirectional link mock-up for avionics applications

Copper-based networks have been extensively employed on aircraft to ensure the avionics data-communications. Since the Airbus A380 development, Avionic Data Communication Network (ADCN) has been implemented to ensure transmissions between avionic equipment. This system is based on the Avionic Full Duplex Ethernet (AFDX), and transfers data at rates up to 100 Mb/s. The need of faster communications systems, up to 1Gb/s, has led to great interest in fiber optic based networks. Beyond higher data rates capabilities, the fiber optics have additional benefits, compared to electrical cables, in terms of weight saving and electromagnetic interference immunity which is strongly needed at gigahertz bandwidths. Multimode fibers (MMF) are becoming increasingly attractive for short-haul (<300m) high-speed interconnections. Besides, Vertical Cavity Surface Emitting Lasers (VCSELs) present interesting performances in comparison to edge-emitting lasers, cost effective and are widely chosen in this type of applications. We aim at achieving an entirely optical fiber Gigabit Ethernet (GbE) link based on 850nm VCSELs to interconnect avionic equipments. To meet IEEE 802.3 standards [1] and ADCN requirements [2], the fiber optic link must be full-duplex, bi-directional, on a single wavelength, and on the same fiber on up to 100m-distance. We have used, at each side of the link, a transceiver module developed for harsh environment applications. Also, there are multiple connections due to production breaks. These connections give birth to return loss (RL) and consequently crosstalk. One might pay attention to the impact of the RL on the link. We present the characterization of a mock-up and the comparison of experimental results with the GbE requirements

Ambient halocarbon mixing ratios in 45 Chinese cities

During this study 158 whole air samples were collected in 45 Chinese cities in January and February 2001. The spatial distribution of different classes of halocarbons in the Chinese urban atmosphere, including chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), Halon-1211, and other chlorinated compounds is presented and discussed. Most of these compounds were enhanced compared to background levels. However, the mean enhancement of CFCs was relatively small, with CFC-12 and CFC-11 increases of 6% (range 1-31%) and 10% (range 2-89%), respectively, with respect to the global background. On the contrary, strongly enhanced levels of CFC replacement compounds and halogenated compounds used as solvents were measured. The average Halon-1211 concentration exceeded the background of 4.3 pptv by 75% and was higher than 10 pptv in several cities. Methyl chloride mixing ratios were also strongly elevated (78% higher than background levels), which is likely related to the widespread use of coal and biofuel in China. © 2006 Elsevier Ltd. All rights reserved

Reduced susceptibility to ischaemic brain damage following photochemical stroke in transgenic mice overexpressing the amyloid precursor protein

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Les lombalgies chroniques : symptôme ou pas symptôme ?

Cet article étudie un aspect psychologique impliqué dans certaines affections somatiques, ici les lombalgies chroniques. Plusieurs cas de patients lombalgiques reçus en entretiens psychothérapiques montrent que le statut de la douleur évolue selon que le sujet lui accorde ou non une valeur de symptôme, au sens psychanalytique. Le « choix » de ce statut est personnel, subjectif, inconscient, et impacte l’évolution de la lombalgie. Après avoir défini le symptôme au sens médical et au sens psychanalytique, et avoir rappelé la distinction entre l’hystérie et la psychosomatique, les auteurs présentent leur conception des rapports corps et psyché selon le modèle de la bande de Möbius utilisée par Lacan pour définir les rapports entre le conscient et l’inconscient. Il est cependant illusoire, en médecine générale, de pouvoir amener tous les patients à faire de leur lombalgie un symptôme « psychanalytique ». Le contexte et le cadre ne sont pas les mêmes car le patient qui va consulter son médecin n’en attend pas la même chose que celui qui va consulter un psychologue, un psychanalyste ou un psychiatre. Néanmoins, l’ouverture des uns et des autres à la possibilité d’une évolution du patient fondée sur un changement de sa position subjective peut être un avantage important, car ce qui est en jeu dans le processus de la chronicisation n’est pas seulement la disparition pure et simple de la douleur, mais la modification préalable de sa fonction pour le sujet, c’est-à-dire le passage de la fonction première de la douleur comme signal de danger à celle qui favorise l’élaboration d’un sens subjectif. Et pour cela, faut-il encore que ce sujet, comme les praticiens concernés, lui reconnaissent cette seconde fonction

Facile Synthesis of High Quality Graphene Nanoribbons

Graphene nanoribbons have attracted attention for their novel electronic and spin transport properties1-6, and because nanoribbons less than 10 nm wide have a band gap that can be used to make field effect transistors. However, producing nanoribbons of very high quality, or in high volumes, remains a challenge. Here, we show that pristine few-layer nanoribbons can be produced by unzipping mildly gas-phase oxidized multiwalled carbon nanotube using mechanical sonication in an organic solvent. The nanoribbons exhibit very high quality, with smooth edges (as seen by high-resolution transmission electron microscopy), low ratios of disorder to graphitic Raman bands, and the highest electrical conductance and mobility reported to date (up to 5e2/h and 1500 cm2/Vs for ribbons 10-20 nm in width). Further, at low temperature, the nanoribbons exhibit phase coherent transport and Fabry-Perot interference, suggesting minimal defects and edge roughness. The yield of nanoribbons was ~2% of the starting raw nanotube soot material, which was significantly higher than previous methods capable of producing high quality narrow nanoribbons1. The relatively high yield synthesis of pristine graphene nanoribbons will make these materials easily accessible for a wide range of fundamental and practical applications.Comment: Nature Nanotechnology in pres

Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization.

BACKGROUND: The recent West African Ebola epidemic led to accelerated efforts to test Ebola vaccine candidates. As part of the World Health Organisation-led VSV Ebola Consortium (VEBCON), we performed a phase I clinical trial investigating rVSV-ZEBOV (a recombinant vesicular stomatitis virus-vectored Ebola vaccine), which has recently demonstrated protection from Ebola virus disease (EVD) in phase III clinical trials and is currently in advanced stages of licensing. So far, correlates of immune protection are incompletely understood and the role of cell-mediated immune responses has not been comprehensively investigated to date. METHODS: We recruited 30 healthy subjects aged 18-55 into an open-label, dose-escalation phase I trial testing three doses of rVSV-ZEBOV (3×105 plaque-forming units (PFU), 3×106 PFU, 2×107 PFU) (ClinicalTrials.gov; NCT02283099). Main study objectives were safety and immunogenicity, while exploratory objectives included lymphocyte dynamics, cell-mediated immunity and cytokine networks, which were assessed using flow cytometry, ELISpot and LUMINEX assay. FINDINGS: Immunization with rVSV-ZEBOV was well tolerated without serious vaccine-related adverse events. Ebola virus-specific neutralizing antibodies were induced in nearly all individuals. Additionally, vaccinees, particularly within the highest dose cohort, generated Ebola glycoprotein (GP)-specific T cells and initiated a cascade of signaling molecules following stimulation of peripheral blood mononuclear cells with Ebola GP peptides. INTERPRETATION: In addition to a benign safety and robust humoral immunogenicity profile, subjects immunized with 2×107 PFU elicited higher cellular immune responses and stronger interlocked cytokine networks compared to lower dose groups. To our knowledge these data represent the first detailed cell-mediated immuneprofile of a clinical trial testing rVSV-ZEBOV, which is of particular interest in light of its potential upcoming licensure as the first Ebola vaccine. VEBCON trial Hamburg, Germany (NCT02283099)

Stellar Populations of Lyman Break Galaxies at z=1-3 in the HST/WFC3 Early Release Science Observations

We analyze the spectral energy distributions (SEDs) of Lyman break galaxies (LBGs) at z=1-3 selected using the Hubble Space Telescope (HST) Wide Field Camera 3 (WFC3) UVIS channel filters. These HST/WFC3 observations cover about 50 sq. arcmin in the GOODS-South field as a part of the WFC3 Early Release Science program. These LBGs at z=1-3 are selected using dropout selection criteria similar to high redshift LBGs. The deep multi-band photometry in this field is used to identify best-fit SED models, from which we infer the following results: (1) the photometric redshift estimate of these dropout selected LBGs is accurate to within few percent; (2) the UV spectral slope (beta) is redder than at high redshift (z>3), where LBGs are less dusty; (3) on average, LBGs at z=1-3 are massive, dustier and more highly star-forming, compared to LBGs at higher redshifts with similar luminosities (0.1L*<~L<~2.5L*), though their median values are similar within 1-sigma uncertainties. This could imply that identical dropout selection technique, at all redshifts, find physically similar galaxies; and (4) stellar masses of these LBGs are directly proportional to their UV luminosities with a logarithmic slope of ~0.46, and star-formation rates are proportional to their stellar masses with a logarithmic slope of ~0.90. These relations hold true --- within luminosities probed in this study --- for LBGs from z~1.5 to 5. The star-forming galaxies selected using other color-based techniques show similar correlations at z~2, but to avoid any selection biases, and for direct comparison with LBGs at z>3, a true Lyman break selection at z~2 is essential. The future HST UV surveys, both wider and deeper, covering a large luminosity range are important to better understand LBG properties, and their evolution.Comment: Accepted for publication in ApJ (29 pages, 9 figures