The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth’s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07–4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77–1.39). Conclusions. In the pooled analysis of 11 case–control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk. © 2022 by the authors.This work is supported by Associazione Italiana per la Ricerca sul Cancro (AIRC), Project no. 21378 (Investigator Grant); Fondazione Italiana per la Ricerca sul Cancro (FIRC); Italian League for the Fight Against Cancer (LILT); European Cancer Prevention (ECP) Organization; and UPMC Start-up Grant (to HNL). P Paragomi was supported by a cancer research training grant from NIH (grant # T32CA186873)

Comparative life cycle impact assessment of electric and conventional bus in Vietnam

Transportation is one of the key sectors causing greenhouse gas (GHG) emissions and air pollution. With the substantial increase in passenger and freight transportation, the corresponding GHG emissions and air pollutants are expected to increase significantly. Recent global and national policies are targeting at reducing environmental impacts of transportation activities. The promotion of public transportation and development of electric buses (e-buses) will reduce the use of fossil fuels in transportation, and consequently, reduce GHG emissions. This study assesses the life cycle GHG emissions and other environmental impacts of e-bus, and compares them with those of conventional bus operated in Vietnam. The results indicate that e-bus is a preferred choice in most of studied environmental impact categories over the whole life cycle such as GHG emission, ozone depletion, ozone formation, fine particulate matter formation, acidification, etc. For GHG emissions, the adoption of electric mobility will reduce 42.62 gCO(2)eq per passenger km of carbon footprint if conventional buses are substituted by e-buses in Vietnam

Life Cycle Energy Consumption and Air Emissions Comparison of Alternative and Conventional Bus Fleets in Vietnam

The study (a) assesses the life cycle energy consumption and air emissions impacts of battery electric buses (e-buses) and conventional buses operated in Vietnam, and (b) compares them with those of hydrogen buses. The results indicate that e-buses and hydrogen buses are preferred options compared to conventional buses in terms of energy consumption, GHG emissions and other air quality impacts over their whole life cycle. Life cycle energy consumption of diesel buses is triple that of e-buses, and is significantly higher than that of hydrogen buses. Replacing conventional buses with e-buses can reduce energy consumption by 50%. For GHG emissions and air quality impacts, the adoption of electric and hydrogen mobility in replacement of conventional buses will reduce GHG emissions by 39%, and other impacts related to air quality by 13% to 90%