DETERMINAN TINDAKAN SADARI SEBAGAI DETEKSI DINI KANKER PAYUDARA PADA WANITA USIA SUBUR (WUS) DI DESA PASAR RAWA KECAMATAN GEBANG KABUPATEN LANGKAT TAHUN 2015

Kanker payudara merupakan penyakit kanker terbanyak yang menyerang wanita di Indonesia. Di Indonesia problem kanker payudara menjadi lebih besar lagi karena lebih dari 70% penderita dating pada stadium yang sudah lanjut. Oleh karena itu dibutuhkan sebuah pemeriksaan yang dapat mendeteksi dini penyakit tersebut, yaitu dengan metode SADARI. Penelitian ini bertujuan untuk menganalisis determinan tindakan SADARI sebagai deteksi dini kanker payudaraWanita Usia Subur (WUS) di Desa Pasar Rawa Kecamatan Gebang Kabupaten Langkat tahun 2015. Jenis penelitian ini adalah penelitian analitik menggunakan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruhWUS di Desa Pasar Rawa Kecamatan Gebang Kabupaten Langkat yang berusia 20-49 tahun sebanyak 316 orang.Sampel dalam penelitian ini sebanyak 62 responden yang diambil dengan simple random sampling melalui pengacakan nomor populasi. Berdasarkan hasil penelitian yang didapat bahwa tidak ada hubungan (p >0,05) antara umur, dorongan dari peer group, pengetahuan, riwayat keluarga dan persepsi tentang pendorong untuk bertindak dan ada hubungan (p< 0,05) antara persepsi tentang kecendrungan gejala penyakit, ancaman penyakit, manfaat dan hambatan. Berdasarkan hasil penelitian tersebut, maka disarankan bagi tenaga kesehatan setempat untuk meningkatkan persepsi positif WUS tentang pelaksanaan SADARI dengan cara penyuluhan secara massal maupun memberikan konseling langsung pada saat memberikan pelayanan kesehatan dengan lebih menekankan pada manfaat SADARI agar WUS bersedia melakukan SADARI setiap bulan secara teratu

DETERMINAN TINDAKAN SADARI SEBAGAI DETEKSI DINI KANKER PAYUDARA PADA WANITA USIA SUBUR (WUS) DI DESA PASAR RAWA KECAMATAN GEBANG KABUPATEN LANGKAT TAHUN 2015

Kanker payudara merupakan penyakit kanker terbanyak yang menyerang wanita di Indonesia. Di Indonesia problem kanker payudara menjadi lebih besar lagi karena lebih dari 70% penderita dating pada stadium yang sudah lanjut. Oleh karena itu dibutuhkan sebuah pemeriksaan yang dapat mendeteksi dini penyakit tersebut, yaitu dengan metode SADARI. Penelitian ini bertujuan untuk menganalisis determinan tindakan SADARI sebagai deteksi dini kanker payudaraWanita Usia Subur (WUS) di Desa Pasar Rawa Kecamatan Gebang Kabupaten Langkat tahun 2015. Jenis penelitian ini adalah penelitian analitik menggunakan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruhWUS di Desa Pasar Rawa Kecamatan Gebang Kabupaten Langkat yang berusia 20-49 tahun sebanyak 316 orang.Sampel dalam penelitian ini sebanyak 62 responden yang diambil dengan simple random sampling melalui pengacakan nomor populasi. Berdasarkan hasil penelitian yang didapat bahwa tidak ada hubungan (p >0,05) antara umur, dorongan dari peer group, pengetahuan, riwayat keluarga dan persepsi tentang pendorong untuk bertindak dan ada hubungan (p< 0,05) antara persepsi tentang kecendrungan gejala penyakit, ancaman penyakit, manfaat dan hambatan. Berdasarkan hasil penelitian tersebut, maka disarankan bagi tenaga kesehatan setempat untuk meningkatkan persepsi positif WUS tentang pelaksanaan SADARI dengan cara penyuluhan secara massal maupun memberikan konseling langsung pada saat memberikan pelayanan kesehatan dengan lebih menekankan pada manfaat SADARI agar WUS bersedia melakukan SADARI setiap bulan secara teratu

Syndromic Approach and Spatial Analysis of Chlamydia trachomatis among Mother with Vaginal Discharge in Medan

Limitations of laboratory facilities in developing countries, makes difficult to diagnose the etiology of sexually transmitted diseases, while effectiveness of using WHO’s syndromic approach can vary widely. The aim of this study is to develop a model of syndromic approach in diagnosing chlamydial infection and perform spatial analysis of primary health care coverage to the spread of chlamydial infection in Medan. Three hundred and twenty women who came to the gynecology clinic with complaints of vaginal discharge were recruited as participants and cervical swab specimens examined by using PCR. Signs and symptoms of vaginal discharge had been assessed by physical and gynecological examination. GIS data coordinate was obtained by visiting subject’s residence and mapping using GPS Garmin's eTrex. The results showed the proportion of chlamydial infection in Medan was 35% and syndromic approach model based on odor, color, and consistency of discharge, and inflammation of the cervix has a sensitivity value of 67% (95% CI:58-76%) and specificity 57% (95% CI:50-64%) and PPV of 46% (95% CI:38-53%) and NPV of 76% (95% CI:70-83%). The spreading pattern of chlamydial infection were distributed evenly throughout the area of ??Medan with a tendency to cluster in the central region (NNA with a value of R=0.78 and the value of Z=-4.4). Primary health care range with radius of 3 km allows it to provide health services to women with vaginal discharge even though their perceptions of facilities availability and health workers capability remain low. The results of the study indicated that the spread of chlamydial infection in the low-risk group was relatively high and evenly spread throughout Medan. Therefore syndromic approach models obtained from this research can be used as a useful and simple approach in diagnosing chlamydial infection. Keywords: Chlamydia trachomatis, vaginal discharge, syndromic approach, spatial analysi

Correlation of Paternal Homocysteine Level and Sperm DNA Fragmentation in Couple with Idiopathic Recurrent Early Pregnancy Loss

Background: Recurrent pregnancy loss is the traumatic event for couples in the effort to obtain offsprings. Various female etiologies have been extensively studied, but more than half of remain unknown. As a result of unification of sperm and oocyte, an embryo combined with any defect during spermatogenesis will also affect the quality of embryo consequently determining the pregnancy outcomes. Routine semen analysis failed to support the evidence of influence of defective sperm in recurrent pregnancy loss. Currently, examination of sperm DNA fragmentation has been added to evaluate the quality of sperm beside the routine semen analysis. We hypothesized that high sperm DNA fragmentation plays a role in the incidence of idiopathic recurrent early pregnancy loss. Beside that, the cause of sperm DNA fragmentation are numerous and remain controversial. This study was conducted to determine the impact of paternal hyperhomocysteinemia on high sperm DNA fragmentation and incidence rates of idiophatic recurrent early pregnancy loss. Material and methods: Fourty partners of idiopathic recurrent early pregnancy loss caes and 40 cases of control from normal male fertile population were included in this study. Blood and semen samples were collected for routine semen analysis, sperm DNA fragmentation, serum and seminal homocysteine. The results were then analyzed to determine the association between sperm and DNA fragmentation, serum homocysteine, seminal homocysteine and incidence rates of idiopathic recurrent early pregnancy loss. Results: incidence rates of idiopathic recurrent early pregnancy loss was significantly associated with sperm DNA fragmentation (p<0.05) and serum homocysteine (p<0.05). Idiopathic recurrent pregnancy loss partners had significantly higher DFI (p<0.05). Hyperhomocysteinemia appears to be associated with significantly increase of sperm DNA fragmentation (p<0.05). Conclusion: Paternal serum homcysteine and high sperm DNA fragmentation was significantly correlated with the incidence rates of idiopathic recurrent early pregnancy loss. Key words : hyperhomocysteinemia, DFI, idiopathic recurrent early pregnancy los

Parity and Maternal Illness and the Incidence of Imminent Abortion

Imminent abortion is the first stage abortion and a threat of abortion. Most of the studies stated that the incidence of abortion is 15-20% of all pregnancies. Complication in imminent abortion is bleeding or infection which can cause mortality. The objective of this research was to analyze the relationship of parity and maternal illness with the incidence of imminent abortion. The research used observational analytic study with case-control design. The samples were 100 participants. The data were analyzed by using univariate analysis and bivariate analysis with chi square test. The result of the bivariate analysis with chi square test showed that there was significant association of parity (p=0.0001) and maternal illness (p=0.0001) on the incidence of imminent abortion. It is recommended that health care providers can detect abortion earlier and also provide counseling for pregnant women about imminent abortion

Vitamin D Levels in Women with Polycystic Ovary Syndrome

INTRODUCTION: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. There is some evidence suggested that vitamin D played a role in the incidence of PCOS. Previous research has found vitamin D deficiency in the pathogenesis of PCOS and cohort studies showing the relationship of obesity with decreased levels of 25-hydroxy vitamin D. Therefore, we aim to conduct a study on vitamin D levels in women with polycystic ovary syndrome.OBJECTIVE: To determine the difference of the levels of vitamin D in women with and without polycystic ovary syndrome.METHODS: This study is a comparative analytical study on two unpaired population by using cross-sectional study design. The study was conducted in Halim Fertility Clinic Medan starting in November 2014 through April 2015. Blood samples were taken from 23 women PCOS and 23 non-PCOS women. Further data were tabulated and analyzed.RESULTS: Vitamin D levels are lower in women with PCOS compared to controls. In the PCOS group, the levels of vitamin D were lower in obese women. Vitamin D levels were also lower in PCOS women with WHR> 0.85.CONCLUSION: This study showed a significant lower level of vitamin D in PCOS patient

IHC Expression Relationships MMP7 and VEGF With Normal Ovaries and Ovarian Pathologies

To investigate the association of MMP7 and VEGF expression with ovarian cancer, benign ovarian cysts, and normal ovaries. This study was analytical research with case-control design. In the study, IHC expression of MMP7 and VEGF was carried out on paraffin block of ovarian cancer tissue, benign ovarian cyst, and normal ovary. In 40 subjects with ovarian tumors, 17 patients were found with positive MMP7 expression. In the control group, no subjects were found with positive MMP7 expression. There was a significant relationship between MMP7 expression and ovarian tumor incidence. Meanwhile, in 40 subjects with ovarian tumors, 21 patients were found with positive VEGF expression. In the control group, no subjects with positive VEGF expression were found. There was a significant relationship between VEGF expression and ovarian tumor incidence. There was a significant relationship between MMP7 and VEGF expression with ovarian tumor incidence

FOLLICULAR CHARACTERISTIC OF VARIOUS STIMULATION REGIMES FOR ASSISTED REPRODUCTIVE TECHNIQUES

Master'sMASTER OF SCIENC