Neumonía bilateral y afectación hepática por COVID-19

The infection by coronavirus SARS-CoV-2 is a new disease named COVID-19. We present the case of a 40 yearoldman with bilateral pneumonia and liver disease by COVID-19.La infección por coronavirus SARS-CoV-2 representa una nueva enfermedad llamada COVID-19. Presentamos el caso de un varón de 40 años con neumonía bilateral y afectación hepática por COVID-19

Abortos de repetición en paciente con anticuerpos antitiroideos positivos

Thyroid dysfunction is common during pregnancy, and both hyperthyroidism and hypothyroidism are associated with increased risk of adverse pregnancy and perinatal outcomes. Accurate assessment of thyroid status and management of thyroid dysfunction in pregnant women are crucial to optimize maternal-fetal outcomes. We present the case of a 31-year-old pregnant women of 16 weeks with recurrent pregnancy loss, subclinical hypothyroidism and positive anti-peroxidase antibodies.La disfunción tiroidea es frecuente durante el embarazo, y tanto el hipertiroidismo como el hipotiroidismo se asocian con un mayor riesgo de efectos adversos para la gestante y peores resultados perinatales. La evaluación precisa de la función tiroidea y el manejo de la disfunción en embarazadas son cruciales para optimizar los resultados maternofetales. Se presenta el caso de una mujer de 31 años, gestante de 16 semanas con abortos de repetición, hipotiroidismo subclínico y anticuerpos antiperoxidasa positivos

Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19

Our main aim was to describe the effect on the severity of ACEI (angiotensin-converting enzyme inhibitor) and ARB (angiotensin II receptor blocker) during COVID-19 hospitalization. A retrospective, observational, multicenter study evaluating hospitalized patients with COVID-19 treated with ACEI/ARB. The primary endpoint was the incidence of the composite outcome of prognosis (IMV (invasive mechanical ventilation), NIMV (non-invasive mechanical ventilation), ICU admission (intensive care unit), and/or all-cause mortality). We evaluated both outcomes in patients whose treatment with ACEI/ARB was continued or withdrawn. Between February and June 2020, 11,205 patients were included, mean age 67 years (SD = 16.3) and 43.1% female; 2162 patients received ACEI/ARB treatment. ACEI/ARB treatment showed lower all-cause mortality (p < 0.0001). Hypertensive patients in the ACEI/ARB group had better results in IMV, ICU admission, and the composite outcome of prognosis (p < 0.0001 for all). No differences were found in the incidence of major adverse cardiovascular events. Patients previously treated with ACEI/ARB continuing treatment during hospitalization had a lower incidence of the composite outcome of prognosis than those whose treatment was withdrawn (RR 0.67, 95%CI 0.63-0.76). ARB was associated with better survival than ACEI (HR 0.77, 95%CI 0.62-0.96). ACEI/ARB treatment during COVID-19 hospitalization was associated with protection on mortality. The benefits were greater in hypertensive, those who continue

Predicting critical illness on initial diagnosis of COVID-19 based on easily obtained clinical variables: development and validation of the PRIORITY model

Objectives: We aimed to develop and validate a prediction model, based on clinical history and examination findings on initial diagnosis of coronavirus disease 2019 (COVID-19), to identify patients at risk of critical outcomes. Methods: We used data from the SEMI-COVID-19 Registry, a cohort of consecutive patients hospitalized for COVID-19 from 132 centres in Spain (23rd March to 21st May 2020). For the development cohort, tertiary referral hospitals were selected, while the validation cohort included smaller hospitals. The primary outcome was a composite of in-hospital death, mechanical ventilation, or admission to intensive care unit. Clinical signs and symptoms, demographics, and medical history ascertained at presentation were screened using least absolute shrinkage and selection operator, and logistic regression was used to construct the predictive model. Results: There were 10 433 patients, 7850 in the development cohort (primary outcome 25.1%, 1967/7850) and 2583 in the validation cohort (outcome 27.0%, 698/2583). The PRIORITY model included: age, dependency, cardiovascular disease, chronic kidney disease, dyspnoea, tachypnoea, confusion, systolic blood pressure, and SpO2 ≤93% or oxygen requirement. The model showed high discrimination for critical illness in both the development (C-statistic 0.823; 95% confidence interval (CI) 0.813, 0.834) and validation (C-statistic 0.794; 95%CI 0.775, 0.813) cohorts. A freely available web-based calculator was developed based on this model (https://www.evidencio.com/models/show/2344). Conclusions: The PRIORITY model, based on easily obtained clinical information, had good discrimination and generalizability for identifying COVID-19 patients at risk of critical outcomes