17 research outputs found
Development and characterization of novel films based on sulfonamide-chitosan derivatives for potential wound dressing
The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190% and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan related to DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging ability. This compound showed also a good ferric reducing power and improved total antioxidant capacity
The Synthesis and the Biological Evaluation of New Thiazolidin-4-one Derivatives Containing a Xanthine Moiety
molecule
The Synthesis and the Biological Evaluation of New Thiazolidin-4-one Derivatives Containing a Xanthine Moiety
Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
Physico-chemical characterization of polymeric matrices based on functionalized chitosan
The synthesis, characterization and biological evaluation of a new nitric oxide donor agent
Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers
In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collagen, gelatin, alginate and elastin. Nanomaterials based on chitosan (CS) or chitosan derivatives are broadly investigated as promising nanocarriers due to their biodegradability, good biocompatibility, non-toxicity, low immunogenicity, great versatility and beneficial biological effects. CS, either alone or as composites, are suitable substrates in the fabrication of different types of products like hydrogels, membranes, beads, porous foams, nanoparticles, in-situ gel, microparticles, sponges and nanofibers/scaffolds. Currently, the CS based nanocarriers are intensely studied as controlled and targeted drug release systems for different drugs (anti-inflammatory, antibiotic, anticancer etc.) as well as for proteins/peptides, growth factors, vaccines, small DNA (DNAs) and short interfering RNA (siRNA). This review targets the latest biomedical approaches for CS based nanocarriers such as nanoparticles (NPs) nanofibers (NFs), nanogels (NGs) and chitosan coated liposomes (LPs) and their potential applications for medical and pharmaceutical fields. The advantages and challenges of reviewed CS based nanocarriers for different routes of administration (oral, transmucosal, pulmonary and transdermal) with reference to classical formulations are also emphasized
MOESM1 of Synthesis and biological evaluation of the new 1,3-dimethylxanthine derivatives with thiazolidine-4-one scaffold
Additional file 1. NMR and HRMS spectra for thiazolidine-4-one derivatives (6a–k)
The synthesis, characterization and biological evaluation of a new nitric oxide donor agent
The synthesis of a new xanthine nitric oxide donor (TSP-81) has been
discussed. The designed compound includes two structural moieties -
theophylline (1,3-dimethylxanthine) and acetaminophen (4-hydroxyacetanilide)
linked by the nitric oxide donor alkyl chain as a spacer. The compound has
been characterized by microanalysis (CHN), 1H-NMR, 13C-NMR, FT-IR, UV-vis, TG
and DTG. The thermal behaviour showed that TSP-81 melts with decomposition,
in four steps, the most important ones being the 2nd one (the registered
weight loss being 17.6 %) and the 3rd one (with a registered weight loss of
30.4 %). The toxicity degree, the anti-inflammatory effect and the ability of
releasing nitric oxide of the TSP-81 have also been evaluated. The biological
assays established that TSP-81 exhibits enhanced biological properties such
as lower toxicity and higher anti-inflammatory effect in reference with
theophylline and acetaminophen, the drugs used as parents molecules. The
TSP-81 is approximately 2 times more active than theophylline and 4 times
more active than acetaminophen in reducing cotton pellet-granuloma formation.
Furthermore, the release of nitric oxide (NO) appears to have an important
contribution to enhancing the anti-inflammatory effect