3 research outputs found
Electrically bioactive coating on Ti with bi-layered SnO2-TiO2 hetero-structure for improving osteointegration
SnO2–TiO2 surface with the bi-layered structure on Ti provides internal electric stimulation to promote osteointegration of implant.</p
Enhanced Osseointegration of Hierarchically Structured Ti Implant with Electrically Bioactive SnO<sub>2</sub>-TiO<sub>2</sub> Bilayered Surface
The poor osseointegration
of Ti implant significantly compromise its application in load-bearing
bone repair and replacement. Electrically bioactive coating inspirited
from heterojunction on Ti implant can benefit osseointegration but
cannot avoid the stress shielding effect between bone and implant.
To resolve this conflict, hierarchically structured Ti implant with
electrically bioactive SnO2–TiO2 bilayered
surface has been developed to enhance osseointegration. Benefiting
from the electric cue offered by the built-in electrical field of
SnO2–TiO2 heterojunction and the topographic
cue provided by the hierarchical surface structure to bone regeneration,
the osteoblastic function of basic multicellular units around the
implant is significantly improved. Because the individual TiO2 or SnO2 coating with uniform surface exhibits
no electrical bioactivity, the effects of electric and topographic
cues to osseointegration have been decoupled via the analysis of in
vivo performance for the placed Ti implant with different surfaces.
The developed Ti implant shows significantly improved osseointegration
with excellent bone–implant contact, improved mineralization
of extracellular matrix, and increased push-out force. These results
suggest that the synergistic strategy of combing electrical bioactivity
with hierarchical surface structure provides a new platform for developing
advanced endosseous implants